J. DAVID SYMONS, PhD portrait
  • Professor, Nutrition & Integrative Physiology
  • Adjunct Professor, Internal Medicine
  • Investigator, Molecular Medicine Program
  • Professor, Nutrition & Integrative Physiology

Research Statement

 

 

Our laboratory investigates vascular function in response to pathophysiological (e.g., obesity/type 2 diabetes, ischemia, hypertension), physiological (e.g., aging, physical exercise), and nutritional (e.g., polyphenolic compounds, metabolites of polyphenolic compounds) interventions. To do so, we use immortalized cells, primary human and rodent cells, isolated blood vessels, intact animals, and humans. 

Research Keywords

  • Vascular function and nutritional interventions
  • Vascular function and exercise
  • Vascular function and disease

Presentations

  • Park SK, Salle DTL, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Similar increases in arterial shear-rate evoked by handgrip exercise activate autophagy and eNOS to a lesser extent in primary endothelial cells from older vs. adult subjects. Arteriosclerosis, Thrombosis, and Vascular Biology Meeting. San Francisco, CA. Presentation, Submitted, 05/2018.
  • Park SK, Salle DTL, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Similar increases in arterial shear-rate evoked by handgrip exercise activate autophagy and eNOS to a lesser extent in primary endothelial cells from older vs. adult subjects. NIH Conference on Autophagy, Bethesda, MD. Presentation, Submitted, 03/2018.
  • Cho JM, Kwon OH, Park SK, Bharath LP, Richardson RS, Babu PVA, Boudina S, Symons JD. Endothelial dysfunction displayed by old mice with repressed vascular autophagy is attenuated by activating purinergic 2Y1 receptors. NIH Conference on Autophagy, Bethesda, MD. Presentation, Submitted, 03/2018.
  • Park SK, La Salle DT, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Similar increases in arterial shear-rate evoked by handgrip exercise activate autophagy and eNOS to a lesser extent in primary endothelial cells from old vs. adult subjects. ATVB/PVD . Presentation, Submitted, 01/2018.
  • Kwon OS, Cho JM, Park SK, Bharath LP, Richardson RS, Babu PVA, Boudina S, Symons JD. Arterial dysfunction displayed by old mice with repressed endothelial cell autophagy is rescued by pharmacological activation of purinergic 2Y1 receptors. Experimental Biology. Presentation, Submitted, 01/2018.
  • Park SK, Salle TL, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Similar increases in arterial shear-rate evoked by handgrip exercise activate autophagy and eNOS to a lesser extent in primary endothelial cells from older vs. adult subjects. NIH Conference : Autophagy as a common pathway in diseases. Presentation, Submitted, 01/2018.
  • Cho JM, Kwon OS, Park SK, Bharath LP, Richardson RS, Babu PVA, Boudina S, and Symons JD.Endothelial dysfunction displayed by old mice with repressed vascular autophagy is attenuated by activating purinergic 2Y1 receptors. NIH Conference : Autophagy as a common pathway in diseases. Presentation, Submitted, 01/2018.
  • Lee J, Bharath LP, Kim JS, Cho JM, Park SK, Ruan T, Symons JD. Small molecule inhibition of protein phosphatase 2A in vivo does not disrupt glucose homeostasis in mice. Experimental Biology. 2018. Presentation, Submitted, 01/2018.
  • Petersen C, Wankhade UM, Wong K, Chintapalli SV, Piccolo BD, Jalili1 T, Symons JD, Shankar K, Babu VA. Strawberry supplementation modifies gut microbiota in obese diabetic db/db mice. American Society for Nutrition, Boston, MA. Presentation, Submitted, 01/2018.
  • Babu VA, Wankhade UM, Petersen C, Wong K,Bharat D, Gholami S, Chintapalli3 SV, Piccolo BD, Symons JD, Shankar K. Influence of blueberry supplementation on gut microbiome in diabetic db/db mice. American Society for Nutrition, Boston, MA . Presentation, Presented, 01/2018.
  • Park SK, La Salle DT, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Rhythmic handgrip exercise elevates arterial shear-rate and increases indices of endothelial cell autophagy and nitric oxide synthase activation in humans. Experimental Biology. 2018. Presentation, Submitted, 01/2018.
  • Cho JM, Park SK, Wallace A, Hauck B, White M, Hansen M, Symons JD. Exercise-training attenuates endothelial dysfunction and repressed vascular autophagy associated with aging in mice. Experimental Biology. Presentation, Submitted, 01/2018.
  • Smith AJ, Andrus C, Barker R, Babu VA, Symons JD, Jalili1 T. Improvements in fasting glucose and HOMA index in diabetic mice fed supplemental dietary Mg are not associated with any changes hepatic insulin stimulated signaling. American Society for Nutrition, Boston, MA. Presentation, Submitted, 01/2018.
  • Bharath LP, Cho JM, Park SK, Ruan T, Li Y, Mueller R, Bean T, Reese V, Richardson RS, Sargsyan A, Cai J, Pires K, Anandh Babu PV, Boudina S, Graham TE, Symons JD. Endothelial cell autophagy maintains shear-stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS. The Physiologist,2017. Conference Paper, Refereed, Presented, 12/2017.
  • Cho Jm, Park SK, Bharath LP, Bean T, Graham TE, Pires K, Buffalo M, Anandh Babu PV, Boudina S, Symons JD. Defective vascular autophagy impairs exercise-induced activation of endothelial nitric oxide synthase in mice. The Physiologist, 2017 . Conference Paper, Refereed, Presented, 12/2017.
  • Cho JM, Park S-K, Wallance A, Hauck B, White M, Hansen M, Symons JD. Exercise-training attenuates endothelial dysfunction and repressed vascular autophagy associated with aging in mice. Submitted for presentation at Experimental Biology 2018. Presentation, Submitted, 12/2017.
  • Lee J, Bharath LP, Kim J-S, Cho JM, Park S-K, Ruan T, Symons JD. Small molecule inhibition of protein phosphatase 2A in vivo does not disrupt glucose homeostasis in mice. Submitted for presentation at Experimental Biology 2018. Presentation, Submitted, 12/2017.
  • Park S-K, La Salle DT, Cerbie J, Cho JM, Nelson A, Morgan DE, Trinity JD, Symons JD. Rhythmic handgrip exercise elevates arterial shear-rate and increases indices of endothelial cell autophagy and nitric oxide synthase activation in humans. Submitted for presentation at Experimental Biology 2018. Presentation, Submitted, 12/2017.
  • Kwon O-S, Cho JM, Park S-K, Bharath LP, Richardson RS, Babu PVA, Boudina S, Symons JD. Arterial dysfunction displayed by old mice with repressed endothelial cell autophagy is rescued by pharmacological activation of purinergic 2Y1 receptors. Submitted for presentation at Experimental Biology 2018. Presentation, Submitted, 12/2017.
  • Petersen C, Bharat D, Cutler BR, Gholami S, Denetso C, Mueller JE, Cho JM, Kim JS, Symons JD, Babu PVA. Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice. Conference Paper, Refereed, Submitted, 11/2017.
  • Yang K, Symons JD. Exercise-training increases basal autophagy-related gene expression in murine arterial endothelial cells. University of Utah Undergraduate Research Symposium, April, 2017. Conference Paper, Presented, 04/2017.
  • Bonn T, Symons JD. Coronary vascular function is improved in ischemic patients after continuous-flow left ventricular assist device implantation. University of Utah Undergraduate Research Symposium, April, 2017. Conference Paper, Presented, 04/2017.
  • Harmon M, Symons JD. Mice with endothelial cell specific disruption of autophagy: a histological evaluation. University of Utah Undergraduate Research Symposium, April, 2017. Conference Paper, Presented, 04/2017.
  • Cho J, Kim JS, Lewis JB, Reynolds PR, Bikman B, and Symons JD. Nasal administration of diesel exhaust particles does not evoke dysfunction or initiate autophagy in murine femoral arteries. FASEB J. 2017 Apr 1;31(1 Supplement):840.26. Conference Paper, Refereed, Presented, 04/2017.
  • Bharat D, Petersen C, Gholami S, Denetso C, Cutler B, Kim JS, Symons JD, Babu PVA. Dietary Blueberries Attenuate Vascular Inflammation and Dysfunction in Diabetic db/db Mice. FASEB J, April 2017 31:166.2. Conference Paper, Refereed, Presented, 04/2017.
  • Petersen C, Bharat D, Cutler B, Gholami S, Denetso C, Mueller JE, Cho J, Kim JS, Symons JD, Babu PVA. Strawberry Supplementation Lessens Vascular Inflammation and Dysfunction Displayed by Diabetic db/db Mice. FASEB J. April 2017. 31:431.5. Conference Paper, Refereed, Presented, 04/2017.
  • JS Kim, LP Bharath, Allsop J, T Bean, T Bonn, G Hestwood, D Nelson, M Drummond, PVA Babu, TE Graham, JD Symons. Exercise-training increases basal autophagy-related gene expression in murine arterial endothelial cells. The Physiologist. J. April 2017. Conference Paper, Refereed, Presented, 04/2017.
  • Cho J, Kim JS, Allsop J, Bean T, Bonn T, Hestwood G, Yang K, Drummond M, Babu PVA, and Symons JD. Basal Endothelial Cell Autophagy is Elevated in Trained vs. Sedentary Mice. FASEB J. April 2017 31:840.25. Conference Paper, Refereed, Presented, 04/2017.
  • Smith AJ, Challburg J, O'Farrell AL, Duke B, Symons JD, Jalili T. A Low Magnesium Diet Worsens Metabolic Disturbances and Insulin Sensitivity in Diabetic Mice. FASEB J. April 2017 31:447.4. Conference Paper, Refereed, Presented, 04/2017.
  • Duke B, Challburg J, Smith AJ, Grover G, Walker E, Symons JD, Jalili T. Four Weeks of Low Magnesium Consumption Can Dysregulate Whole-Body Metabolism and Body Composition in Mice. FASEB J. April 2017. 31:965.44. Conference Paper, Refereed, Presented, 04/2017.
  • Yang K, Symons JD. Exercise-training increases indices of autophagy in endothelial cells and intact arteries. Utah Conference for Undergraduate Research (Utah Valley University), Feb, 2017. Conference Paper, Presented, 02/2017.
  • Bean T, and Symons. Exercise-training increases basal autophagy to an extent that improves arterial function. Posters on the Hill. Conference Paper, Presented, 01/2017.
  • Bonn T, Symons JD. Coronary Vascular Function Is Improved in Ischemic Patients After Continuous-Flow Left Ventricular Assist Device Implantation. Utah Cardiac and Recovery Symposium, Jan, 2017. Conference Paper, Presented, 01/2017.
  • Hestwood G, Symons JD. Histological evaluation of arteries from mice with endothelial-cell specific disruption of autophagy. University of Utah Undergraduate Research Symposium. Conference Paper, Presented, 04/2016.
  • Bean T, Symons JD. Endothelial cell specific disruption of autophagy: effect on blood pressure, arterial stiffness, and arterial permeability in mice. University of Utah Undergraduate Research Symposium . Conference Paper, Presented, 04/2016.
  • Bharat D, Begaye N, Ramos R, Ferreira, M, Li YY, Cutler B, Bharath LP, Symons JD, Jalili T, Babu PVA. Lipotoxicity-Evoked Reductions in Nitric Oxide Bioavailability and Exaggerated Oxidant Stress are Blunted by Blueberry Metabolites in Human Vascular Endothelial Cells. FASEB J, April 2016 30:1175.3. Conference Paper, Refereed, Presented, 04/2016.
  • Bharath LP, Ruan T, Babu PVA, Boudina S, Graham TE, Symons JD. Intact autophagy is requisite to maintain shear-stress-induced nitric oxide generation by endothelial cells via a novel glucose-dependent purinergic signaling pathway. FASEB J, April 2016 30:1130.3. Conference Paper, Refereed, Presented, 04/2016.
  • Bharath LP, Ruan T, Li YY, Zhang QJ, Abel ED, Symons JD. Mechanisms Responsible for Ceramide-Induced Vascular Dysfunction Observed in vitro are Operational in vivo. FASEB J, April 2015 29:818.11. Conference Paper, Refereed, Presented, 04/2015.
  • Bharath LP, Ruan T, Forostyan T, Sargsyan A, Goodrich R, Han Y, Mueller R, Babu PVA, Boudina S, Graham T, Symons JD. Cross-talk between autophagy and mitophagy regulates shear-induced nitric oxide production in endothelial cells. FASEB J, 2015.29:896.3. Conference Paper, Refereed, Presented, 04/2015.
  • Ruan T, Bharath LP, Mueller R, Goodrich R, Graham T, Symons JD. Shear-Induced Extracellular Regulated Kinase Signaling to eNOS is Increased When Autophagy is Compromised in Endothelial Cells. FASEB J, April 2015 29:956.4. Conference Paper, Refereed, Presented, 04/2015.
  • Cavalcanti R, Begaye N, Costa M, Bharath LP, Symons JD, Jalili T, Rajasekaran NS, Jia Z, Babu PVA. Metabolites of blueberry anthocyanins suppress lipotoxicity induced endothelial inflammation. FASEB J, April 2015 29:118.6. Conference Paper, Refereed, Presented, 04/2015.
  • Li YY, Bharath LP, Quan Y, Mah E, Guo Y, Hawkins M, Bruno R, Babu PVA, Jalili T, Symons JD. y-carboxyethyl hydroxychroman preserves nitric oxide bioavailability by attenuating oxidative stress and inflammation in endothelial cells treated with high glucose. FASEB J, April 2015 29:758.1. Conference Paper, Refereed, Presented, 04/2015.
  • Munday D, Symons JD. Protein phosphatase 2A inhibition preserves arterial function in obese mice. National Conference for Undergraduate Research, Eastern Washington University, Cheney, WA, March, 2015. Conference Paper, Presented, 03/2015.
  • Munday D, Symons JD. Protein phosphatase 2A inhibition preserves arterial function in obese mice. Utah Conference on Undergraduate Research, Dixie State University, St. George, UT February 2015. Conference Paper, Presented, 02/2015.
  • Goodrich R, Mueller R, Munday D, Jaojoco B, Bharath LP, Li YY, Babu PVA, Graham T, Symons JD. Vascular autophagy, nitric oxide bioavailability, and arterial aging. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Presentation, 01/2015. Conference Paper, Presented, 01/2015.
  • Park S, Richardson R, Abel E., Rossman M, Valdez S, Bevins J, Symons JD and Riehle C. Swim training improves indices of vascular mitochondrial function. Medicine and Science in Sports and Exercise, 2015. Conference Paper, Refereed, Presented, 01/2015.
  • Novel mediators of cardiovascular disease in diabetes. Title: Lipotoxicity, ceramides, and endothelial dysfunction. Invited Talk/Keynote, Presented, 06/15/2014.
  • Deeter L, Diakos N, Stehlik J, Selzman C, Kfoury A, Reid B, Saidi A, Wever- Pinzon O, Verma D R, Yen CG, Uzoigwe E, Guo S, Li D, Drakos S, Symons JD. Coronary vascular function is improved in ischemic patients after continuous-flow left ventricular assist device implantation. FASEB J, 2014; 28 : 1071.8. Conference Paper, Refereed, Presented, 06/2014.
  • Uzoigwe E, Panneerseelan L, Li Y, Deeter L, Kunz D, Jionang Dapeu E, Graham TE, Symons JD. Physiological and pathophysiological stimuli alter endothelial cell autophagy. FASEB J, 2014; 28 : 737.4. Conference Paper, Refereed, Presented, 06/2014.
  • Panneerseelan L, Ruan T, Li Y, Babu PVA, Wan X, Kunz D, Walker M, Nhan J, Ravindran A, Zhang GJ, Abel ED, Symons JD. PP2A activation in vivo is sufficient to disrupt interactions among vascular Akt-Hsp90-eNOS FASEB J, 2014; 28 : 1013.16. Conference Paper, Refereed, Presented, 06/2014.
  • Li Y, Quan Y, Panneerseelan L, Mah E, Guo Y, Hawkins M, Jalili T, Bruno R, Symons JD. γ-Tocopherol supplementation attenuates arterial dysfunction in db/db mice. FASEB J, 2014; 28 : 260.8. Conference Paper, Refereed, Presented, 06/2014.
  • Qian Y, Panneerseelan L, Symons JD, Babu PVA, Jalili T. Metabolites of polyphenols preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. FASEB J, 2014; 28 : 372.6. Conference Paper, Refereed, Presented, 06/2014.
  • Mah E, Li Y, Guo Y, Lim Y, Jalili T, Symons JD, Bruno RS. γ-Tocopherol attenuates liver injury In diabetic (db/db) mice with nonalcoholic fatty liver disease. FASEB J, 2014; 28 : 260.7. Conference Paper, Refereed, Presented, 06/2014.
  • Young LM, Marcus RL, LaStayo PC, Drummond MJ, Graham TE, and Symons JD. The effect of acute exercise on circulating serum retinol binding protein 4 in seniors with and without impaired glucose tolerance. FASEB J, 2014; 28 : 863.4. Conference Paper, Refereed, Presented, 06/2014.
  • Panneerseelan-Bharath L, Ruan T, Li Y-Y, Deeter L, Kunz D, Zhang Q-J, Abel ED, Symons JD. Protein phosphatase 2A activation contributes to cardiovascular complications that occur in mice with diet-induced obesity. Diabetes xx:xx-xx. Presentation, Presented, 06/2014.
  • Babu PVA, Kim EM, Panneerseelan L, Muthuswamy V, Jalili T, Soorappan RN, Symons JD, Jia Z. Berry anthocyanins and their metabolite ameliorate high glucose-induced adhesion of monocytes to human aortic endothelial cells by modulating the cross-talk between eNOS and NFkB signaling. Arteriosclerosis, Thrombosis, and Vascular Biology, May 2014. Conference Paper, Refereed, Presented, 05/2014.
  • Deeter L, Diakos N, Stehlik J, Selzman C, Kfoury A, Reid B, Saidi A, Wever-Pinzon O, Verma DR, Yen C, Uzoigwe E, Guo S, Li D, Drakos S, Symons JD. Coronary vascular function is improved in ischemic patients after continuous-flow left ventricular assist device implantation. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at National Conference on Undergraduate Research, The University of Kentucky, Lexington, Kentucky. Conference Paper, Presented, 04/2014.
  • Deeter L, Uzoigwe E, Panneerseelan L, Li Y, Kunz D, Jionang-Dapeu E, Graham TE, Symons JD. Physiological and pathophysiological stimuli alter endothelial cell autophagy. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at National Conference on Undergraduate Research, The University of Kentucky, Lexington, Kentucky. Conference Paper, Presented, 04/2014.
  • Wan X, Symons JD. Protein phosphatase 2A activation contributes to endothelial dysfunction that occurs in mice with diet-induced obesity. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Brigham Young University, Provo, Utah. Conference Paper, Presented, 02/2014.
  • Ruan T, Symons JD. Protein phosphatase (PP) 1 and PP2B do not contribute to palmitate-induced disruption of eNOS enzyme function. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Brigham Young University, Provo, Utah. Conference Paper, Presented, 02/2014.
  • Walker M, Symons JD. PP2A inhibition using LB1 negates palmitate-induced reductions in nitric oxide production in endothelial cells. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Brigham Young University, Provo, Utah. Conference Paper, Presented, 02/2014.
  • Deeter L, Symons JD. Coronary vascular function is improved in ischemic patients following continuous-flow left ventricular assist device implantation. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Brigham Young University, Provo, Utah. Conference Paper, Presented, 02/2014.
  • Deeter L, Uzoigwe E, Kunz D, Mills T, Jionang-Dapeu E, Symons JD, Sargsyan A. Physiological and Pathophysiological Stimuli Alter Endothelial Cell Autophagy. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2014.
  • Ruan T, Symons JD. Ceramide initiates PP2A colocalization with eNOS by dissociating PP2A from I2PP2A. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Summer Student Roundtable. Conference Paper, Presented, 08/2013.
  • Wan X, Symons JD. Protein phosphatase 2A activation is required for lipid-induced arterial dysfunction in mice. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Summer Student Roundtable. Conference Paper, Presented, 08/2013.
  • Panneerseelan L, Ruan T, Nhan J, Ravindran A, Li YY, Zhang QJ, Holland W, Abel ED, Symons JD. PP2A inhibition in vivo attenuates lipid-induced disruption among vascular Akt-Hsp90-eNOS and negates endothelial dysfunction. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at The Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators, Louisville, Kentucky. TOP CONFERENCE ABSTRACT WINNER. Conference Paper, Presented, 08/2013.
  • Yen CG, Diakos NA, Stehlik J, Kfoury AG, Selzman CH, Reid BB, Everitt MD, Wever-Pinzon O, Myrick C, Salama M, Hammond MEH, Li DY, Symons JD, Drakos SG. Continuous-Flow Ventricular Assist Devices Impact on Failing Heart's Vasculature. J Heart Lung Transplant 2013; 32 (4S) : S642. Conference Paper, Refereed, Presented, 06/2013.
  • Nhan J, Panneerseelan L, Ruan T, Wan X, Johnson E, Li YY, Zhang QJ, Abel ED, Symons JD. PP2A activation is required for lipid-induced arterial dysfunction in mice. FASEB J, 2013; 27 : 917.10. Conference Paper, Refereed, Presented, 06/2013.
  • Panneerseelan L, Ruan T, Ravindran A, Li YY, Zhang QJ, Abel ED, Symons JD. Ceramide initiates PP2A colocalization with eNOS at the cell membrane by dissociating PP2A from I2PP2A in the cytosol. FASEB J, 2013; 27 : 924.14 . Conference Paper, Refereed, Presented, 06/2013.
  • Johnson E, Diakos N, Selzman C, Reid B, Stehlik J, Kfoury A, Saidi A, Wever-Pinzon O, Verma DR, Yen CG, Li D, Drakos S, Symons JD. Coronary arterial function is not impaired in patients following continuous-flow left ventricular assist device implantation. FASEB J, 2013; 27 : 1185.11. Conference Paper, Refereed, Presented, 06/2013.
  • Symons JD. American College of Sports Medicine / 4th World Congress on Exercise is Medicine. Symposium title: Molecular mechanisms of lipotoxicity. Symposium speaker : Lipid mediated vascular dysfunction May 2013. Invited Talk/Keynote, Presented, 05/2013.
  • Hawkins M, Symons JD, Jalili T. Does gamma-tocopherol lower blood pressure in diabetic mice? College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, University State University, Logan, Utah. Conference Paper, Presented, 04/2013.
  • Ruan T, Johnson E, Nhan J, Wan X, Symons JD. Ceramide disrupts the association between PP2A and I2PP2A and impairs eNOS enzyme function and endothelium-dependent vasorelaxation. Undergraduate Research Abstracts 2: (13), 2013, p. 29. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • D’Elia P, Dapeu E, Wan X, Johnson E, Hawkins M, Uzoigwe E, Deeter L, (Symons JD, Panneerseelan L, Li Y, Jalili T). Gamma tocopherol supplementation attenuates dysfunction in db/db mice. Undergraduate Research Abstracts 1: (13), 2013, p. 31. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Hawkins M, Fernandes P, Dapeu E, Wan X, Johnson E, Deeter L, Zhang C, (Panneerseelan L, Li Y, Bruno R, Symons JD, Jalili T). Does gamma-tocopherol lower blood pressure in diabetic mice? Undergraduate Research Abstracts 1: (13), 2013, p. 37. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Panneerseelan L, Ruan T, Ravindran A, Li YY, Zhang QJ, Holland W, Abel ED, Symons JD. Ceramide disrupts the association between I2PP2A and PP2A and causes endothelial dysfunction in vivo. Diabetes xx: xx-xx. Conference Paper, Presented, 04/2013.
  • Wan X, Symons JD. Protein phosphatase 2A activation is required for lipid-induced arterial dysfunction in mice. Undergraduate Research Abstracts 1: (13), 2013, p. 135. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Ruan T, Symons JD. Ceramide initiates PP2A co-localization with eNOS by dissociating PP2A from I2PP2A. Undergraduate Research Abstracts 1: (13), 2013, p. 130. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Nhan J, Symons JD. Measuring nitric oxide production by endothelial cells using electron paramagnetic resonance spectroscopy. Undergraduate Research Abstracts 1: (13), 2013, p. 127. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Johnson E, Symons JD. Coronary arterial function is not impaired in patients following continuous-flow left ventricular assist device implantation. Undergraduate Research Abstracts 1: (13), 2013, p. 121. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Ravindran A, Symons JD. Measuring cellular ceramide accrual using immunofluorescence. Undergraduate Research Abstracts 1: (13), 2013, p. 129. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Undergraduate Research Symposium, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 04/2013.
  • Wan X, Nhan J, Panneerseelan L, Ruan T, Johnson E, Li Y, Zhang Q, Abel E, Symons JD. Protein phosphatase 2A activation is required for lipid-induced arterial dysfunction in mice. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at National Conference on Undergraduate Research, The University of Wisconsin-LaCrosse, LaCrosse, Wisconsin. Conference Paper, Presented, 04/2013.
  • Nhan J, Panneerseelan L, Ruan T, Wan X, Johnson E, Li YY, Zhang QJ, Abel ED, Symons JD. PP2A activation is required for lipid-induced arterial dysfunction in mice. FASEB J, 2013; 27 : 917.10. Conference Paper, Refereed, Presented, 04/2013.
  • Panneerseelan L, Ruan T, Ravindran A, Li YY, Zhang QJ, Holland W, Abel ED, Symons JD. Ceramide disrupts the association between I2PP2A and PP2A and causes endothelial dysfunction in vivo. Diabetes 62:A99-A172. Conference Paper, Refereed, Presented, 04/2013.
  • Johnson E, Diakos N, Selzman C, Reid B, Stehlik J, Kfoury A, Saidi A, Wever-Pinzon O, Verma DR, Yen CG, Li D, Drakos S, Symons JD. Coronary arterial function is not impaired in patients following continuous-flow left ventricular assist device implantation. FASEB J, 2013; 27 : 1185.11. Conference Paper, Refereed, Presented, 04/2013.
  • Ravindran A, Symons JD. Measuring cellular ceramide accrual using immunofluorescence. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Utah State University, Logan, Utah. Conference Paper, Presented, 02/2013.
  • Wan X, Symons JD. PP2A activation is required for lipid-induced arterial dysfunction in mice. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Utah State University, Logan, Utah. Conference Paper, Presented, 02/2013.
  • Nhan J, Symons JD. Measuring nitric oxide production by endothelial cells using electron paramagnetic resonance spectroscopy. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Utah State University, Logan, Utah. Conference Paper, Presented, 02/2013.
  • Johnson E, Symons JD. Continuous-flow left ventricular assist device does not impair coronary arterial function after implantation. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Utah State University, Logan, Utah. Conference Paper, Presented, 02/2013.
  • Johnson E, Diakos N, Selzman C, Reid B, Stehlik J, Kfoury A, Saidi A, Wever-Pinzon O, Verma D, Yen C, Li D, Drakos S, Symons JD. Coronary arterial function is not impaired in patients following continuous-flow left ventricular assist device implantation. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Cardiac Recovery Symposium, University of Utah School of Medicine, Salt Lake City, Utah. Conference Paper, Presented, 01/2013.
  • Ruan T, Nhan J, Johnson E, Wan X, Ravindran A, Symons JD. Ceramide disrupts the association between PP2A and I2PP2A and impairs eNOS enzyme function and endothelium-dependent vasorelaxation. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Research Posters on the Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2013.
  • Begay W, Symons JD. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Native American Research Internship (NARI) Program Conference. Conference Paper, Presented, 01/2013.
  • Ruan T, Ravindran A, Zhang QJ, Abel ED, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. FASEB J, 2012; 26 : 1057.17. Conference Paper, Refereed, Presented, 06/2012.
  • Calvert R, Noh J, Pereira R, Ruan T, Doo-Hyun K, Zhang QJ, Accili D, Abel ED, Symons JD. Sirtuin-1 gain of function increases endothelium-dependent vasorelaxation of murine femoral arteries. FASEB J, 2012; 26 : 853.18 . Conference Paper, Refereed, Presented, 06/2012.
  • Jalili T, Bosse J, Dolinsky V, Zhang QJ, Abel ED, Symons JD. A carbohydrate restricted-high fat diet reduces blood pressure in spontaneously hypertensive rats without causing insulin resistance. FASEB J, 2012; 26 : 869.12. Conference Paper, Refereed, Presented, 06/2012.
  • Morton M, Symons JD. Ceramide causes PP2A translocation from cytosol to membrane. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2012.
  • Ravindran A, Ruan T, Calvert R, Symons JD. Measuring cellular ceramide accrual using immunofluorescence. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at National Conference for Undergraduate Research/Utah Conference of Undergraduate Research Joint Meeting, Weber State University, Ogden, Utah. Conference Paper, Presented, 01/2012.
  • Ravindran A, Symons JD. Measuring cellular ceramide accrual using immunofluorescence. University of Utah Undergraduate Research Abstracts, Spring 2012; 12 : 135. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2012.
  • Kim BJ, Symons JD. Does ceramide contribute to vascular dysfunction in type 1 diabetes? College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Korean Student Technical Leadership Conference, Chicago, IL. Conference Paper, Presented, 01/2012.
  • Shelton Q, Wood L, Calvert R, Drakos S, Diakos N, Pinzon OW, Li D, Symons JD. The influence of left ventricular assist device implantation on coronary vascular function. University of Utah Undergraduate Research Abstracts, Spring 2012; 12 : 141. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2012.
  • Ruan T, Ravindran A, Calvert R, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at National Conference for Undergraduate Research/Utah Conference of Undergraduate Research Joint Meeting, Weber State University, Ogden, Utah. Conference Paper, Presented, 01/2012.
  • Kivimaki A, Symons JD. Lipid-induced ceramide accrual decreases vascular function in a protein phosphatase 2A mediated manner. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at SACNAS National Conference, Advancing Hispanics,/Chicanos and Native Americans in Science, Seattle, WA Fri-342. Conference Paper, Presented, 01/2012.
  • Kivimaki A, Symons JD. Lipid-induced ceramide accrual decreases vascular function in a protein phosphatase 2A mediated manner. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Native American Research Internship (NARI) Program Conference, Salt Lake City, UT. Conference Paper, Presented, 01/2012.
  • Ravindran A, Ruan T, Calvert R, Symons JD. How does ceramide activate protein phosphatase 2A. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2012.
  • Ruan T, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. University of Utah Undergraduate Research Abstracts, Spring 2012; 12 : 136. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2012.
  • Calvert R, Symons JD. Sirtuin-1 gain of function increases endothelium-dependent vasorelaxation in murine arteries. University of Utah Undergraduate Research Abstracts, Spring 2012; 12 : 117. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2012.
  • Ruan T, Symons JD. Lipid-induced arterial dysfunction is less severe after PP2A inhibition in conscious mice. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2012.
  • Nhan J, Symons JD. Measuring nitric oxide production by endothelial cells using electron paramagnetic resonance spectroscopy. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2012.
  • Miller CJ, Ramachandran K, Khanderao GD, Kannan S, Rajasekaran V, Bohme C, Symons JD, Davidson CJ, and Soorappan RN. Acute exercise stress and ROS Signaling: activation of Nrf2/ARE-Dependent antioxidant defense mechanisms in the mouse myocardium. Circ. Res., Dec 2011; 109: AP317. Conference Paper, Refereed, Presented, 12/2011.
  • Ives SJ, Andtbacka RHI, Noyes RD, Morgan RG, Symons JD, Richardson RS. Reductions in extracellular pH modulate alpha-adrenergic sensitivity in human arteries in vitro: 2412. Medicine & Science in Sports & Exercise, 2011; 43 (5) : 651. Conference Paper, Refereed, Presented, 06/2011.
  • Nichols A, Deeter N, Deesing M, Zhang QJ, Kowalski C, Holland WL, Summers SA, Abel ED, Symons JD. Ceramide evokes vascular dysfunction independent of effects on insulin sensitivity and glucose homeostasis. FASEB J, 2011; 25 : 821.8. Conference Paper, Refereed, Presented, 06/2011.
  • Zhang QJ, Deeter NB, Nichols A, Deesing M, Kowalski C, Holland WL, Summers SA, Abel, ED, Symons JD. Ceramide-induced vascular dysfunction results from PP2A association with eNOS. Diabetes, June 2011; 71 : 576-P. Conference Paper, Refereed, Presented, 06/2011.
  • Deeter NB, Symons JD. Mice with targeted disruption of the enzyme dihydroceramide desaturase display metabolic disturbances but not vascular dysfunction in response to high-fat feeding. University of Utah Undergraduate Research Abstracts, May 2011; 11 : 65. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Nichols A, Deeter NB, Zhang QJ, Kowalski C, Abel ED, Symons JD. Ceramide biosynthesis impairs endothelial nitric oxide synthase phosphorylation secondary to protein phosphatase 2A activation in endothelial cells. University of Utah Undergraduate Research Abstracts, May 2011; 11 : 24. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Nichols A,Deeter N, Symons JD. Pharmacological and genetic evidence that ceramide evokes vascular dysfunction in mice with diet-induced obesity. University of Utah Undergraduate Research Abstracts, May 2011; 11 : 132. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Pham A, Symons JD. Coronary arteries from Cirko mice are less vulnerable to dysfunction evoked by chronic pressure overload: examining several mechanism that might be responsible. University of Utah Undergraduate Research Abstracts, May 2011; 11 : 155. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Sarmiento J, Symons JD. Mice with targeted disruption of the enzyme dihyrdoceramide desaturase (des) develop characteristics of the metabolic syndrome. University of Utah Undergraduate Research Abstracts, May 2011; 11:155. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Petersen B, Symons JD. Myocardial function and substrate use in fat-fed mice with targeted disruption of dihydroceramide desaturase. University of Utah Undergraduate Research Abstracts, May 2011; 11 : 67. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at University of Utah Undergraduate Research Conference, Salt Lake City, Utah. Conference Paper, Presented, 05/2011.
  • Zhang QJ, Deeter N, Nichols A, Deesing M, Kowalski C, Holland W, Summers SA, Abel ED, Symons JD. Ceramide induced vascular dysfunction results from PP2A association with eNOS. Keystone Symposia on Molecular and Cellular Biology : Lipotoxicity. Kerry, Ireland, May 2011. Conference Paper, Refereed, Presented, 05/2011.
  • Ostler E, Symons JD. Procedures required to track intracellular protein movement and protein-protein interactions. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2011.
  • Deeter N, Nichols A, Deesing M, Zhang QJ, Holland W, Kowalski C, Summers SA, Abel ED, Symons JD. Ceramide biosynthesis impairs endothelial nitric oxide synthase phosphorylation secondary to protein phosphatase 2A activation in endothelial cells. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Weber State University, Ogden, Utah. Conference Paper, Presented, 01/2011.
  • Nichols A, Deeter N, Deesing M, Zhang QJ, Holland W, Kowalski C, Summers SA, Abel ED, Symons JD. Mice with targeted disruption of the enzyme dihydroceramide desaturase display metabolic disturbances but not vascular dysfunction in response to high-fat feeding. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Weber State University, Ogden, Utah. Conference Paper, Presented, 01/2011.
  • Nichols A, Deeter N, Deesing M, Zhang QJ, Holland W, Kowalski C, Summers SA, Abel ED, Symons JD. Mice with targeted disruption of the enzyme dihydroceramide desaturase display metabolic disturbances but not vascular dysfunction in response to high-fat feeding. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2011.
  • Ruan T, Symons JD. Endogenous ceramide decreases the association between PP2A and I2PP2A. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2011.
  • Ostler E, Sabic H, Ruan T, Ravindran A, Kim C, Q-J Zhang, and Symons JD. Mechanisms whereby ceramide might activate the protein phosphatase 2A. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Frank Tyler Research Trainee Symposium: Molecular Medicine and Medical School Research Programs, Snow Park Lodge, Deer Valley Resort, Park City, Utah. Conference Paper, Presented, 01/2011.
  • Ravindran A, Symons JD. Quantification of ceramide using immunofluorescence. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2011.
  • Deeter N, Deesing M, Zhang QJ, Nichols A, Kowalski C, Abel ED, Symons JD. Mice with targeted disruption of the enzyme dihydroceramide desaturase display metabolic disturbances but not vascular dysfunction in response to high-fat feeding. International Society for Heart and Vascular Metabolism, Kananaskis, Alberta, Canada. Conference Paper, Refereed, Presented, 08/2010.
  • Zhang QJ, Wilson L, Kowalski C, McCamey D, Boehme C, Baker W, Rou J, Ambal K, Soorappan R, Abel ED, Symons JD. Ceramide-induced impairment of endothelial nitric oxide synthase function in bovine aortic endothelial cells (BAECs) is not secondary to defective upstream signaling kinases or peroxynitrite formation. International Society for Heart and Vascular Metabolism Kananaskis, Alberta, Canada. Conference Paper, Refereed, Presented, 08/2010.
  • Soorappan RN, Khanderao GD, Sadhaasivam K, Rajasekaran V, Boehme C, Symons JD, Davidson CJ. Nrf2 deficiency impairs ARE-dependent cardiac antioxidant mechanisms in aged mice. Free Radical Biology & Medicine, 2010; 49 (Suppl. 1) : S82. Conference Paper, Refereed, Presented, 06/2010.
  • Tanner J, Kearns D, Kim BJ, Sloan C, Yang G, Jia Z, Yang T, Abel ED, Symons JD. The tempo of cardiovascular and metabolic responses to fasting is different between lean and obese mice. FASEB J, 2010; 24 : 978.15. Conference Paper, Refereed, Presented, 06/2010.
  • Zhang QJ, Wilson L, Pettey D, Arrant C, Kowalski C, Abel ED, Symons JD. Palmitate evokes ceramide-dependent reactive oxygen species (ROS) generation from sources other than NADPH oxidase in bovine aortic endothelial cells (BAECs). FASEB J, 2010; 24 : 602.7. Conference Paper, Refereed, Presented, 06/2010.
  • Wilson L, Zhang QJ, Arrant C, Pettey D, Kowalski C, McCamey D, Boehme C, Baker W, Soorappan RN, Abel ED, Symons JD. Ceramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formation. FASEB J, 2010; 24 : 978.16. Conference Paper, Refereed, Presented, 06/2010.
  • Zhang QJ, Wende AR, Guo A, Sena S, Symons JD, Abel ED. Inhibition of starvation-induced autophagy in cardiomyocytes by insulin signaling is independent of nutrient availability. Diabetes, 2010; 70 : 43-OR. Conference Paper, Refereed, Presented, 06/2010.
  • Ives SJ, Zhao J, Noyes RD, Andtbacka R, McDaniel J, Symons JD, Hayman M, Wray DW, Richardson R. Alpha adrenergic sensitivity and temperature in human arteries: the role of nitric oxide. FASEB J, 2010; 24 (1) : 804.15. Conference Paper, Refereed, Presented, 06/2010.
  • Khanderao GD, Varadharaj S, Kannan S, Firpo MA, Boehme C, Symons JD, Soorappan RN.TNF-alpha activates Nrf2/ARE signaling and promotes GSH synthesis in HL-1 cardiomyocytes. Free Radical Biology & Medicine, 2010; 49 (Suppl. 1) : S132. Conference Paper, Refereed, Presented, 06/2010.
  • Larson A, Guo Y, Black KS, Hayman MA, Richardson RS, Bruno RS, Jalili T, Symons JD. A single dose of quercetin lowers blood pressure in hypertensive but not prehypertensive males. FASEB J, 2010; 24 : 230.6. Conference Paper, Refereed, Presented, 06/2010.
  • Barton C, Bosse J, Symons JD. Dietary carbohydrate composition influences the severity of vascular dysfunction in spontaneously hypertensive rats. University of Utah Undergraduate Research Abstracts, Spring 2010; 10 : 9. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Deeter NB, Deesing MA, Symons JD. Does ceramide contribute to vascular dysfunction? evidence from mice with targeted disruption of the enzyme dihydroceramide desaturease. University of Utah Undergraduate Research Abstracts, Spring 2010; 10 : 23. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Kowalski C, Wilson L, Zhang QJ, Arrant CJ, Pettey DH, McCamey D, Boehme C, Baker W, Soorappan RN, Abel ED, Symons JD. Ceramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formation. Presented at National Conference on Undergraduate Research, University of Montana, Missoula, Montana. Conference Paper, Presented, 01/2010.
  • Pettey DH, Zhang QJ, Wilson L, Arrant CJ, Kowalski C, Symons JD. Palmitate evokes ceramide-dependent reactive oxygen species (ROS) generation from sources other than NADPH oxidase in bovine aortic endothelial cells (BAECs). Presented at Utah Conference on Undergraduate Research, Southern Utah University, Cedar City, Utah. Conference Paper, Presented, 01/2010.
  • Kowalski C, Deesing M, Deeter N, Symons JD. Ceramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formation. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Deeter N, Deesing M, Symons JD. Do mice with targeted disruption of the enzyme dihydroceramide desaturase (des) develop characteristics of the metabolic syndrome? Presented at Utah Conference on Undergraduate Research, Southern Utah University, Cedar City, Utah. Conference Paper, Presented, 01/2010.
  • Deesing MA, Deeter NB, Symons JD. Do mice with targeted disruption of the enzyme dihydroceramidedesaturase (DES) develop characteristics of the metabolic syndrome? University of Utah Undergraduate Research Abstracts, Spring 2010; 10 : 22. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Deeter N, Deesing M, Symons JD. Does ceramide contribute to vascular dysfunction in des1+/- mice? Presented at National Conference on Undergraduate Research, University of Montana, Missoula, Montana. Conference Paper, Presented, 01/2010.
  • Peterson B, Kim BJ, Symons JD. Does ceramide accumulation contribute to cardiac dysfunction in mice with type-1 diabetes? University of Utah Undergraduate Research Abstracts, Spring 2010; 10 : 63. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Kowalski C, Wilson L, Rou J, Symons JD. Ceramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formation. University of Utah Undergraduate Research Abstracts, Spring 2010; 10 : 48. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2010.
  • Symons JD, Holland W, Gale D, Tanner J, Cahoon J, Wilson L, Losee J, Pettey D, Narra K, Wang LP, Abel ED, Summers S. Endogenous ceramide biosynthesis impairs vascular function in a tissue autonomous manner. Diabetes, 2009; 55 (Suppl. 1) : A361. Conference Paper, Refereed, Presented, 06/2009.
  • Lin HY, Soesanto WS, Symons JD, Jalili T. A high fat diet reduces blood pressure, but not cardiac hypertrophy in spontaneously hypertensive rats. FASEB J, 2009; 23 : 362.2 . Conference Paper, Refereed, Presented, 04/2009.
  • Symons JD, Holland W, Gale D, Tanner J, Wilson L, Cahoon J, Losee J, Pettey DH, Narra K, Wang LP, Abel ED, Summers SA. Endogenous ceramide biosynthesis impairs vascular function in a tissue autonomous manner. Presented at Joint Conference on Complications of Diabetes and Obesity / Dissecting the vasculature: function, molecular mechanisms and malfunction. Conference Paper, Presented, 03/2009.
  • Arrant CJ, Symons JD. Ceramide increases superoxide anion production as assessed via EPR. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart association Roundtable Meeting. Conference Paper, Presented, 01/2009.
  • Wilson L, Gale D, Pettey DH, Cahoon J, Tanner J, Narra K, Wang LP, Abel ED, Symons JD. Endogenous ceramide biosynthesis impairs vascular function in a tissue autonomous manner. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2009.
  • Pettey DH, Wilson LJ, Gale DC, Zhang QJ, Tanner JM, Symons JD. Endogenous ceramide biosynthesis inpairs insulin-mediated NO production in BAECs via mechanisms independent of Akt. University of Utah Undergraduate Research Abstracts, Spring 2009; 9 : 47. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2009.
  • Wilson L, Symons JD. Ceramide increases ROS production in a ceramide-dependent and independent manner. Presented at American Heart association Roundtable Meeting. Conference Paper, Presented, 01/2009.
  • Larson A, Bruno R, Guo Y, Gale D, Tanner J, Jalili T, Symons JD. Acute quercetin supplementation does not lower blood pressure or ACE activity in normotensive males. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Dietetics Association Annual General Meeting, Denver, Colorado. Conference Paper, Presented, 01/2009.
  • Tanner J, Kim BJ, Symons JD. Cardiovascular and metabolic responses to fasting in lean and obese mice. Presented at National Conference on Undergraduate Research, University of LaCrosse, LaCrosse, Wisconsin. Conference Paper, Presented, 01/2009.
  • Symons JD, Holland W, Gale D, Tanner J, Wilson L, Cahoon J, Losee J, Pettey DH, Narra K, Wang LP, Abel ED, Summers SA. Endogenous ceramide biosynthesis impairs vascular function in a tissue autonomous manner. Presented at Keystone Symposia: dissecting the vasculature: function, molecular mechanisms, and malfunction; and complications of diabetes and obesity. Conference Paper, Presented, 01/2009.
  • Gale D, Pettey DH, Wilson L, Tanner JM, Symons JD. Pharmacological and genetic models indicate that ceramide accrual impairs vascular function in a tissue autonomous manner. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at Utah Conference on Undergraduate Research, Westminster College, Salt Lake City, Utah. Conference Paper, Presented, 01/2009.
  • Finnerty N, Shelton L, Symons JD. Insulin-mediated phosphorylation of endothelial nitric oxide synthase occurs predominantly within the endothelial layer of arterial vessels. University of Utah Undergraduate Research Abstracts, Spring 2009; 9 : 19. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2009.
  • Mitchell C, Symons JD. Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes? Presented at American Heart association Roundtable Meeting. Conference Paper, Refereed, Presented, 01/2009.
  • Wang N, Symons JD, Zhang H, Yang G, Jia Z, Gonzalez FJ, Litwin SE, Soodvilai S, Yang T. Distinct functions of vascular endothelial and smooth muscle PPAR{gamma} in regulation of blood pressure and vascular tone. FASEB J, 2008; 22 : 737.42. Conference Paper, Refereed, Presented, 06/2008.
  • Symons JD, Holland W, Tanner J, Kearns D, Cahoon J, Palionyte M, Duncan B, Losee J, Narra K, Hillas E, Rohrwasser A, Abel ED, Summers S. Inhibiting vascular ceramide synthesis prevents arterial dysfunction and hypertension in mice with diet-induced obesity. FASEB J, 2008; 22 : 743.5. Conference Paper, Refereed, Presented, 06/2008.
  • Jalili T, Soesanto WS, Hu E, Lin H, Symons JD. The mammalian target of rapamycin plays a critical role in the development of cardiac hypertrophy in spontaneously hypertensive rats. Circulation, 2008; 118 (18 Suppl. 2) : S276. Conference Paper, Refereed, Presented, 06/2008.
  • Tanner T, Symons JD. The effects of exercise and obesity on endothelial nitric oxide synthase (eNOS) and cardiovascular homeostasis. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2008.
  • Losee J, Tanner T, Kearns DT, Cahoon J, Palionyte M, Duncan B, Simpson S, Symons JD. Inhibiting vascular ceramide synthesis prevents arterial dysfunction and hypertension in mice with diet-induced obesity. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2008.
  • Tanner J, Kearns DT, Cahoon J, Palionyte M, Duncan B, Losee J, Simpson S, Symons JD. Inhibiting vascular ceramide synthesis prevents arterial dysfunction and hypertension in mice with diet-induced obesity. Presented at National Conference on Undergraduate Research, Salisbury University, Salisbury, Maryland. Conference Paper, Presented, 01/2008.
  • Cahoon J, Palionyte M, Simpson S, Grisham J, Lee J, Boehm K, Symons JD. Ceramide accumulation impairs vascular function: increased reactive oxygen species production and decreased eNOS phosphorylation might play a role. Presented at National Conference on Undergraduate Research, Salisbury University, Salisbury, Maryland. Conference Paper, Presented, 01/2008.
  • Losee J, Tanner JM, Kearns DT, Cahoon J, Palionyte M, Duncan BB, Simpson S, Symons JD. Inhibiting vascular ceramide synthesis prevents arterial dysfunction and hypertension in mice with diet-induced obesity. University of Utah Undergraduate Research Abstracts, Spring 2008; 8 : 57. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2008.
  • Tanner JM, Kearns DT, Cahoon J, Symons JD. Cardiovascular responses to fasting in lean and obese mice. University of Utah Undergraduate Research Abstracts, Spring 2008; 8 : 92. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2008.
  • Symons JD, McMillin S, Tanner J, Birnbaum MJ, Riehle C, Palionyte M, Abel ED. Vascular resistance to insulin-mediated signal transduction via Akt1 is not sufficient to produce hypertension in mice. Presented at Keystone Symposia on Metabolism and Cardiovascular Risk, Breckenridge, Colorado. Conference Paper, Presented, 01/2008.
  • Thuet W, Symons JD. Residue targets of Akt, PKA, ERK, and AMPK on the eNOS enzyme in arteries from treadmill-running mice. Presented at Frank Tyler Research Trainee Symposium: Molecular Medicine and Medical School Research Programs, Snow Park Lodge, Deer Valley Resort, Park City, Utah. Conference Paper, Presented, 01/2008.
  • Edwards R, Symons JD. The effects of lipid infusion to mice on ceramide and vascular function. Presented at Frank Tyler Research Trainee Symposium: Molecular Medicine and Medical School Research Programs, Snow Park Lodge, Deer Valley Resort, Park City, Utah. Conference Paper, Presented, 01/2008.
  • Tanner J, Kearns D, Cahoon J, Symons JD. Cardiovascular responses to fasting in lean and obese mice. Presented at Utah Conference on Undergraduate Research, Utah Valley University, Orem, Utah. Conference Paper, Presented, 01/2008.
  • Tanner J, Kearns D, Cahoon J, Duncan B, Losee J, Palionyte M, Symons JD. Inhibiting vascular ceramide prevents arterial dysfunction and hypertension in mice with diet-induced obesity. Presented at Utah Conference on Undergraduate Research, Utah Valley University, Orem, Utah. Conference Paper, Presented, 01/2008.
  • Liljenquist JC, Smith J, McMillin S, Symons JD. Acute exercise increases intracellular signaling kinase activity that can phosphorylate eNOS in mice. University of Utah Undergraduate Research Abstracts, Spring 2008; 8 : 86. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2008.
  • Jalili T, Soesanto WS, Hu E, Han-Yi L, Symons JD. mTOR plays a critical role in the development of cardiac hypertrophy in spontaneously hypertensive rats. Presented at Keystone Symposia on Metabolism and Cardiovascular Risk, Breckenridge, Colorado. Conference Paper, Refereed, Presented, 01/2008.
  • Cahoon J, Holland W, Gale D, Boehm K, Pettey DH, Tanner J, Losee J, Wilson L, Palmer D, Narra K, Wang LP, Abel ED, Summers SA, Symons JD. (2008). Endogenous ceramide biosynthesis impairs vascular function. Presented Keystone Symposia on Metabolism and Cardiovascular Risk, Breckenridge, Colorado. Conference Paper, Refereed, Presented, 01/2008.
  • Smith R, Symons JD. Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes? College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Heart Association Roundtable Meeting. Presentation, Presented, 01/2008.
  • Liu H, Jia Z, Soodvilai S, Guan G, Symons JD, Yang T. Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury. Presented at American Society of Nephrology, Philadelphia, Pennsylvania. Presentation, Presented, 01/2008.
  • Wang N, Symons JD, Jia Z, Gonzalez FJ, Yang T. Distinct functions of vascular endothelial and smooth muscle PPARg in regulation of blood pressure and vascular tone. Presented at American Society of Nephrology, Philadelphia, Pennsylvania. Presentation, Presented, 01/2008.
  • Wang N, Jia Z, Yang G, Zhang H, Soodvilai S, Symons JD, Gonzalez FJ, Litwin SE, Yang T. Vascular PPARg controls circadian variation of blood pressure and heart rate via activation of Bmal1. College of Health, and Division of Endocrinology, Metabolism and Diabetes University of Utah. Presented at American Society of Nephrology, Philadelphia, Pennsylvania. Presentation, Presented, 01/2008.
  • McMillin S, de AmorimFilho JA, Abel ED, Symons JD. Acute treadmill-running increases intracellular signaling kinases that phosphorylate eNOS in the vasculature of mice. FASEB J, 2007; 21 (5) : A573. Conference Paper, Refereed, Presented, 06/2007.
  • Symons JD, McMillin SL, Birnbaum MJ, Abel ED. Loss of Akt1-mediated signal transduction in the vasculature is not sufficient to evoke systemic hypertension in mice. FASEB J, 2007; 21 (6) : A831. Conference Paper, Refereed, Presented, 06/2007.
  • DeAmorimFilho J and Symons JD. Vascular signaling kinases activate eNOS during acute treadmill-running. Frank Tyler Research Trainee Symposium: Molecular Medicine and Medical School Research Programs, Snow Park Lodge, Deer Valley Resort, Park City, Utah. Conference Paper, Presented, 01/2007.
  • Duncan B, Cahoon J, McDonald B, Palionyte M, Symons JD. Contributions from ceramide to vascular dysfunction. University of Utah Undergraduate Research Abstracts, Spring 2007; 7 : 21. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2007.
  • Cahoon J, Symons JD. Measurements of nitric oxide via amperometric and fluorescent methods. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2007.
  • Palionyte M, McDonald B, Duncan B, Cahoon J, Symons JD. The contribution from Ceramide to vascular dysfunction in diet-induced obesity. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2007.
  • Liljenquist JD, Smith J, McMillin S, Symons JD. Acute exercise increases intracellular signaling kinase activity that can phosphorylate eNOS in mice. University of Utah Undergraduate Research Abstracts, Spring 2007; 7 : 71. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2007.
  • Palionyte M, McDonald B, Duncan B, Cahoon J, Symons JD. The contribution from Ceramide to vascular dysfunction in diet-induced obesity. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2007.
  • Schumann C, Symons JD. Insulin-mediated vasorelaxation in a genetic and diet-induced model of insulin resistance. University of Utah Undergraduate Research Abstracts, Spring 2007; 7 : 62. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2007.
  • Simpson S, Symons JD. Endogenous ceramide production impairs insulin-mediated signal transduction in bovine aortic endothelial cells. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2007.
  • Palionyte M and Symons JD. Ceramide inhibition improves insulin-mediated signal transduction in the vasculature of mice with diet-induced obesity. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2007.
  • Symons JD, McMillin S, Lloyd J, Miller N, Snedeger B, Accili D, Abel ED. Differential effects of selective versus total loss of vascular insulin signaling on blood pressure regulation. Diabetes, 2006; 55 : A303. Conference Paper, Presented, 06/2006.
  • Jalili T, Lefler S, Symons JD, Carlstrom J. Activation of cardiac ERK, Akt and S6 kinase, but not PKC, prior to cardiac hypertrophy in spontaneously hypertensive rats. FASEB J, 2006; 20 (4 Pt 1) : A638. Conference Paper, Refereed, Presented, 06/2006.
  • Symons JD, McMillin S, Lloyd J, Miller N, Snedeger B, Accili D, Abel ED. Hypertension exists in mice with selective, but not total, impairment of insulin signal transduction in the vasculature. FASEB J. 2006; 20 : A1394. Conference Paper, Refereed, Presented, 06/2006.
  • DeAmorimFilho J, Symons JD. Treadmill running increases intracellular signaling kinases that phosphorylate eNOS in intact blood vessels. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2006.
  • McMillin S, Symons JD. Differential effects of selective vs. total loss of vascular insulin signaling on blood pressure regulation. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2006.
  • Clark M, McMillin S, Symons JD. Selective insulin resistance in the vasculature leads to hypertension. University of Utah Undergraduate Research Abstracts, Spring 2006; 6 : 14. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2006.
  • Healy E, Symons JD. Coronary arteries form mice with cardiac-selective deletion of the insulin receptor are resistant to dysfunction evoked by pressure-overload. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2006.
  • Healy E, Symons JD. Coronary arteries from mice with cardiac-selective deletion of the insulin receptor are resistant to dysfunction evoked by pressure-overload. Conference Paper, Presented, 01/2006.
  • Healy E, Symons JD. Coronary arteries form mice with cardiac-selective deletion of the insulin receptor are resistant to dysfunction evoked by pressure-overload. University of Utah Undergraduate Research Abstracts, Spring 2006; 6 : 31. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2006.
  • Cueva C, Smith A, Lefler S, Symons JD, Carlstrom J, Jalili T. Activation of ERK1/2 Akt and S6 kinase, but not PKC, prior to cardiac hypertrophy in spontaneously hypertensive rats. University of Utah Undergraduate Research Abstracts, Spring 2006; 6 : 18. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2006.
  • McMillin S, Symons JD. Differential effects of selective vs. total loss of vascular insulin signaling on blood pressure regulation. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2006.
  • Jalili T, Carlstrom JA, Wu TC, Litwin SE, Symons JD. Quercetin consumption delays, but does not prevent hypertension and cardiovascular complications in spontaneously hypertensive rats (SHR). FASEB J, 2005; 19 : A453. Conference Paper, Refereed, Presented, 06/2005.
  • Lloyd JB, Symons JD. Coronary vascular function in insulin receptor-deficient mice. The Physiologist, 2005: 3 (48): 101. Conference Paper, Refereed, Presented, 06/2005.
  • Symons JD, Ping H, Litwin SE. Coronary arteries form mice with cardiac-selective deletion of the insulin receptor (CIRKO) are resistant to dysfunction evoked by pressure-overload. Circulation, 2005; 112 : U121. Conference Paper, Refereed, Presented, 06/2005.
  • Symons JD, Johnson J, Lloyd J, Crapo R, Daniels W, Dobson C, Accili D, Abel ED. Evidence for nitric oxide-independent vasorelaxation in coronary arteries from insulin receptor null mice. FASEB J, 2005; 19 : A1260. Conference Paper, Refereed, Presented, 06/2005.
  • Symons JD, Johnson J, Lloyd J, Crapo R, Daniels W, Dobson C, Accili D, Abel ED. Nitric oxide independent vasorelaxation: heterogeneity of responses in the peripheral vasculature of insulin receptor null mice. FASEB J, 2005; 19 : A1241. Conference Paper, Refereed, Presented, 06/2005.
  • Daniels WD, Johnson J, Clegg D, Crapo R, Symons JD. Arterial reactivity in insulin receptor-deficient mice: the splanchnic and skeletal muscle circulations. University of Utah Undergraduate Research Abstracts, Spring 2005; 5 : 19. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2005.
  • Johnson J, Daniels DW, Dobson C, Clegg D, Crapo R, Lloyd J, Symons JD. Coronary vascular function in insulin receptor deficient mice. Presented at Research Posters On The Hill, Utah State Capital, Salt Lake City, Utah. Conference Paper, Presented, 01/2005.
  • Dobson C, Johnson J, Lloyd J, Symons JD. Coronary vascular function in insulin receptor-deficient mice. University of Utah Undergraduate Research Abstracts, Spring 2005; 5 : 22. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2005.
  • Symons JD, Carlstrom J, Dong L, Jalili T. Quercetin limits dysfunction of mesenteric arteries from spontaneously hypertensive rats. FASEB J, 2004; 18 : A362.312. Conference Paper, Refereed, Presented, 06/2004.
  • Symons JD, Simonsen U. Simultaneous measures of vascular relaxation and nitric oxide concentration in rat coronary artery: effects of hyperhomocysteinemia. FASEB J, 2004; 18 : A200.7. Conference Paper, Refereed, Presented, 06/2004.
  • Symons JD, Carlstrom JA, Li D, Jalili T. Quercetin lessens mesenteric arteriolar dysfunction in spontaneously hypertensive rats. FASEB J, 2004; 18 (4) : A62.17. Conference Paper, Refereed, Presented, 06/2004.
  • Symons JD, Rodesch C, Pattathu R. Do low folate and hyperhomocysteinemia contribute independently to vascular superoxide production? FASEB J, 2004; 18 : A434.437. Conference Paper, Refereed, Presented, 06/2004.
  • Symons JD, Pattathu RA, and Rodesch C. Low-folate and hyperhomocysteinemia increase vascular superoxide anion generation. FASEB J, 2004; 18 (4) : A434.7. Presentation, Presented, 06/2004.
  • Lloyd J, Symons JD. Dihydroethidium staining to assess superoxide anion production in the vasculature of mice with whole-body deletion of the insulin receptor. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2004.
  • Johnson J, Dong L, Symons JD. Do low folate and hyperhomosyteinemia contribute independently to vascular dysfunction. University of Utah Undergraduate Research Abstracts, Spring 2004; 4 : 35. Presented at University of Utah Undergraduate Research Conference, University of Utah, Salt Lake City, Utah. Conference Paper, Presented, 01/2004.
  • Crapo R, Symons JD. Peripheral vascular reactivity in mice with whole-body deletion of the insulin receptor. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2004.
  • Snedeger B, Symons JD. Coronary vascular reactivity in mice with whole body deletion of the insulin receptor. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2004.
  • Zaid UB, Mullick AE, Rutledge JC, Symons JD. Hyperhomocystenemia (HHcy) and low folate contribute independently to increasing carotid arterial permeability in mice. FASEB J, 2003; 17 (4) : A525. Conference Paper, Refereed, Presented, 06/2003.
  • Symons JD, Nguyen H, Williams B, Jalili T. Quercetin limits vascular dysfunction associated with left-ventricular hypertrophy (LVH). FASEB J, 2003; 17 (4) : A397.5. Conference Paper, Refereed, Presented, 06/2003.
  • Hayashi Y, Symons, JD. High-intensity treadmill-running improves coronary microvascular function in rats. Medicine & Science in Sports & Exercise, 2003; 35 (5) : S121. Conference Paper, Refereed, Presented, 06/2003.
  • Purcell R, Symons JD. (2003). Spontaneously hypertensive rats: aortic, coronary, and mesenteric vascular dysfunction is lessened by chronic quercetin feeding. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2003.
  • Symons JD. High-intensity internal-training: effects on ischemia-induced myocardial and coronary vascular dysfunction. FASEB J, 2002; 16 (4) : A442-43. Conference Paper, Refereed, Presented, 06/2002.
  • Mullick AE, Symons JD. Functional and biochemical indices of vascular impairment in rats with hyperhomocysteinemia evoked by folate-depletion. Arterioscler Thromb Vasc Biol, 2002; 22 (5) : A45. Conference Paper, Refereed, Presented, 06/2002.
  • Tenorio FA, Ensuna JL, Keen CL, Symons JD. Does manganese deficiency reduce arginase activity to an extent whereby vascular function is altered? Arterioscler Thromb Vasc Biol, 2002; 22 (5) : A45. Conference Paper, Refereed, Presented, 06/2002.
  • Zaid UB, Mullick AE, Rutledge JC, Symons JD. Arterial permeability and stiffness are increased in mice with hyperhomocysteinemia evoked by methionine supplementation. Arterioscler Thromb Vasc Biol, 2002; 22 (5) : A21-A22. Conference Paper, Refereed, Presented, 06/2002.
  • Williams B, Symons JD. Chronic quercetin feeding improves vascular reactivity of rat thoracic aorta. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2002.
  • Pattathu RA, Rodesch C, Symons JD. Do low folate and hyperhomocysteinemia contribute independently to vascular superoxide production? Presented at American College of Sports Medicine, Southwest Chapter, Annual Meeting; Student award competition at the American College of Sports Medicine, Southwest Chapter. Conference Paper, Presented, 01/2002.
  • Q Nguyen, Symons JD. Chronic quercetin feeding lessens vascular dysfunction evoked by pressure-overload hypertrophy. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2002.
  • Pattathu R, Symons JD. Low folate, hyperhomocysteinemia, and their combination : effects on superoxide anion production. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2002.
  • Musch TI, McAllister RM, Symons JD, Hirai T, Hageman KS, Poole DC. Vascular conductance during high intensity exercise in rats: effects of nitric oxide synthase inhibition. Medicine & Science in Sports & Exercise, 2001; 33 (5 Suppl.) : S21. Conference Paper, Refereed, Presented, 06/2001.
  • Zaid UB, Symons JD. Arterial permeability is increased in mice with hyperhomocysteinemia evoked by methionine supplementation. Presented at American Heart Association Roundtable Meeting. Conference Paper, Presented, 01/2001.
  • Nethery VM, Symons JD. Na+/H+ exchanger subtype 1 inhibition limits ischemia and reperfusion-induced coronary vascular dysfunction. American Heart Association: Molecular, Integrative, and Clinical Approaches to Myocardial Ischemia. Seattle, WA. Conference Paper, Refereed, Presented, 01/2001.
  • Rendig SV, Symons JD, Amsterdam EA. Effects of pravastatin, atorvastatin and simvastatin on myocardial stunning in pigs. FASEB J, 2000; 14 (4) : A423. Conference Paper, Refereed, Presented, 06/2000.
  • Symons JD, Rendig SV, and Hayashi Y. High intensity interval-training: effects on coronary vascular function after ischemia and reperfusion. The Physiologist, 2000; 43 (4). Conference Paper, Refereed, Presented, 06/2000.
  • Symons JD. Do elevated plasma concentrations of homocysteine alter coronary resistance vessel function in rats? FASEB J, 2000; 14 (4) : A161. Conference Paper, Refereed, Presented, 06/2000.
  • Rendig SV, Symons JD, Longhurst JC, Amsterdam EA. Effects of red wine, alcohol and the red wine flavonoid, quercetin on isolated coronary resistance and conductance arteries. JACC, 2000; 35 (2) : 245A. Conference Paper, Refereed, Presented, 06/2000.
  • Symons JD, Rendig SV, Amsterdam EA. Pravastatin, simvastatin, and atorvastatin: effects on coronary resistance vessel function from stunned myocardium of swine. FASEB J, 2000; 14 (4) : A423. Conference Paper, Refereed, Presented, 06/2000.
  • Symons JD, Kappagoda CT, Dhond MR, Kittleson MK, Gunawardena S. Endothelium-dependent relaxation of coronary resistance vessels is enhanced after 12 weeks of mitral regurgitation in rabbits. FASEB J, 1999; 13 : A1084. Conference Paper, Refereed, Presented, 06/1999.
  • Symons JD, Schaefer S. Na+-H+ exchange (NHE) inhibition preserves endothelial function of resistance vessels in response to myocardial ischemia. FASEB J, 1999; 13 : A1085. Conference Paper, Refereed, Presented, 06/1999.
  • Symons JD, Rendig SV, Stebbins CL, Longhurst JC. Receptor-mediated coronary artery constriction after ischemia: influence of exercise training. Medicine & Science in Sports & Exercise, May 1999; 31 : S227. Conference Paper, Refereed, Presented, 06/1999.
  • Musch TI, Hageman KS, Symons JD. The angiotensin II (ANG II): nitric oxide (NO) interaction during exercise in rats with heart failure-splanchnic and renal conductance. FASEB J, 1998; 12 (4) : A118. Conference Paper, Refereed, Presented, 06/1998.
  • Guo ZL, Symons JD, Longhurst JC. Bradykinin-mediated activation of ischemically sensitive abdominal visceral afferents: contributions from phosphoinositide and cyclooxygenase pathways. FASEB J, 1998; 24 (1-2) : 871. Conference Paper, Refereed, Presented, 06/1998.
  • Guo ZL, Symons JD, Fu LW, Longhurst JC. Protein kinase C contributes to bradykinin-mediated activation of ischemically sensitive abdominal visceral afferents. FASEB J, 1998; 12 (5) : A689. Conference Paper, Refereed, Presented, 06/1998.
  • Symons JD, Rendig SV, Benton J, Stebbins CL, Longhurst JC. Does exercise training lessen ischemia-induced dysfunction of resistance vessels in stunned myocardium? FASEB J, 1998; 12 (5) : A1114. Conference Paper, Refereed, Presented, 06/1998.
  • Symons JD, Hageman KS, Musch TI. Angiotensin II opposes nitric oxide (NO) mediated vasodilation in skeletal muscle during exercise in rats with heart failure. Medicine & Science in Sports & Exercise, May 1998; 30 : S212. Conference Paper, Refereed, Presented, 06/1998.
  • Rendig SV, Symons JD, Longhurst JC, Amsterdam EA. Quercetin, a biologically active flavonoid, relaxes isolated rabbit coronary arteries. FASEB J, 1998; 12 (4) : A405. Conference Paper, Refereed, Presented, 06/1998.
  • Symons JD, Martin L, Schaefer S. Na+/H+ exchange inhibition (NHEi) attenuates myocardial dysfunction of short-term hibernation in swine. FASEB J, 1997; 11 (3) : A74. Conference Paper, Refereed, Presented, 06/1997.
  • Symons JD, Musch TI, Hageman KS, Stebbins CL. Nitric oxide (NO) attenuates angiotensin II (AII) - induced increases in vascular resistance. Medicine & Science in Sports & Exercise,1997; 29 (5 Suppl.) : S139. Conference Paper, Refereed, Presented, 06/1997.
  • Batra S, Peters BP, Symons JD, Hazard DY, Del Balzo U, Bradley JD, Flaim SF. A perflubron-based oxygen carrier increases skeletal muscle, venous effluent and mixed venous PO-2 in hemodiluted dogs. FASEB J, 1996; 10 (3) : A383. Conference Paper, Refereed, Presented, 06/1996.
  • Hageman KS, Symons JD, Musch TI. Muscle blood flow differences between male and female rats measured at rest and during exercise. The Physiologist, 1996; 39 (5) A43. Conference Paper, Refereed, Presented, 06/1996.
  • Musch TI, Hageman KS, Symons JD. Skeletal muscle blood flow response to exercise before and after nitric oxide synthase inhibition in male and female rats. The Physiologist, 1996; 39 (5): A42. Conference Paper, Refereed, Presented, 06/1996.
  • Symons JD, Stebbins CL, Musch TI. Nitric oxide attenuates the pressor activity of angiotensin II during exercise. The Physiologist, 1996; 39 (5):A42. Conference Paper, Refereed, Presented, 06/1996.
  • Symons JD, Rendig S, Fu LW, Longhurst JC. Endothelin (ET)-A receptor blockade increases regional myocardial blood flow in left-circumflex occluded swine. FASEB J, 1996; 10 (3) : A324. Conference Paper, Refereed, Presented, 06/1996.
  • Keipert PE, Batra S, Peters BP, Symons JD, Hazard DY, Del Balzo U, Bradley JD, Flaim S. A perflubron-based oxygen carrier improves gut oxygenation in a dog model of surgical anemia. Anesthesiology, 1996; 85 (3A) : A219. Conference Paper, Refereed, Presented, 06/1996.
  • Del Balzo U, Symons JD, Sun X, Harrell RA, Flaim SF. Perfusion with perflubron emulsion attenuates high-energy phosphates depletion during low-flow ischemia in isolated rabbit hearts. FASEB J, 1996; 10 (3) : A319. Conference Paper, Refereed, Presented, 06/1996.
  • Symons JD, Harrell RA, Flaim SF, Del Balzo U. Perlubron emulsion increases tolerance to myocardial ischemia in the isolated rabbit heart. FASEB J, 1995; 9 (3) : A622. Conference Paper, Refereed, Presented, 06/1995.
  • Symons JD, Stebbins CL. Angiotensin II (Ang II) alters transmural blood flow distribution in exercising miniswine. Medicine & Science in Sports & Exercise, 1995; 27 (5) : S96. Conference Paper, Refereed, Presented, 06/1995.
  • Symons JD, Stebbins CL. Angiotensin II (ANG II) modulates myocardial blood flow via AT-1 receptors in exercising miniswine. FASEB J, 1994; 8 : A289. Conference Paper, Refereed, Presented, 06/1994.
  • Symons JD, Stebbins CL. Splanchnic blood flow responses to nicotine infusion at rest and during treadmill running in miniswine. Medicine & Science in Sports & Exercise, 1994; 26 (5 Suppl.) : S132. Conference Paper, Refereed, Presented, 06/1994.
  • Symons JD, Stebbins CL. Angiotensin II regulates total peripheral resistance and myocardial blood flow in exercising miniswine. Medicine & Science in Sports & Exercise, May 1993; 25 (5 Suppl.) : S26. Conference Paper, Refereed, Presented, 06/1993.
  • Symons JD, Stebbins CL. Nicotine infusion and cardiovascular function during exercise. FASEB J, 1993; 7 (3-4) : A451. Conference Paper, Refereed, Presented, 06/1993.
  • Amsterdam EA, Rendig SV, Pan HL, Symons JD, Longhurst JC. Reduction of myocardial infarct size in pigs with BW-755C by attenuation of neutrophil function without alteration of neutrophil migration. FASEB J, 1992; 6 (4) : A1248. Conference Paper, Refereed, Presented, 06/1992.
  • Symons JD, Stebbins CL. Angiotensin converting enzyme inhibition attenuates exercise-induced increases in plasma lysine vasopressin in miniswine: 168. Medicine & Science in Sports & Exercise, 1992; 24 (5 Suppl.) : S28. Conference Paper, Refereed, Presented, 06/1992.
  • Firoozmand E, Symons JD, Longhurst JC. Repeated dipyridamole infusion does not alter transumural myocardial capillary density in miniswine. FASEB J, 1992; 6 (5) : A2037. Conference Paper, Refereed, Presented, 06/1992.
  • Symons JD, Firoozmand E, Longhurst JC. Repeated dipyridamole infusion enhances collateral-dependent flow and regional function during exercise evidence supporting the mechanical hypothesis. FASEB J, 1992; 6 (4) : A1506. Conference Paper, Refereed, Presented, 06/1992.
  • Symons JD, Theodossy SJ, Longhurst JC, Stebbins CL. Effect of low-intensity contraction and arterial occlusion on intramuscular prostanoid concentration. FASEB J, 1991; 1 : A764. Conference Paper, Refereed, Presented, 06/1991.
  • Symons JD, Longhurst JC, Stebbins CL. Vasopressin release during exercise does not attenuate collateral-dependent flow or function in ameroid-occluded miniswine. The Physiologist. 226:11.5 . Conference Paper, Refereed, Presented, 06/1991.
  • Pitsillides K, Symons JD, Longhurst JC. A miniature ultrasonic transit-time dimension system for measuring left ventricular wall motion. FASEB J, 1990; 4 (3) : A693. Conference Paper, Refereed, Presented, 06/1990.
  • Symons JD, Stebbins CL, Theodossey SJ, Longhurst JC. PGE-2 and 6 KETO-PGF-alpha increase in skeletal muscle following 30s of static hindlimb contraction. FASEB J, 1990; 4 (4) : A1072. Conference Paper, Refereed, Presented, 06/1990.
  • Amsterdam EA, Symons JD, Stahl GL, Longhurst JC. Evidence for myocardial ischemia associated with cardiac dysfunction induced by complement C5A. FASEB J, 1989: 3 (3) : A688. Conference Paper, Refereed, Presented, 06/1989.
  • Symons JD, Longhurst JC. Chronic beta-adrenergic blockade does not attenuate coronary collateral flow in miniswine. Circulation, 1989; 80 (4 Suppl. 2) : II310. Conference Paper, Refereed, Presented, 06/1989.
  • Stahl GL, Symons JD, Amsterdam EA, Longhurst JC. Zymosan-activated serum and C5A induce similar alterations in coronary flow and myocardial function. Clinical Research, 1989; 37 (2) : 522A. Conference Paper, Refereed, Presented, 06/1989.
  • Stahl GL, Amsterdam EA, Symons JD, Longhurst JC. Complement C5A-induced myocardial ischemia role of cyclooxygenase and lipoxygenase metabolites. Circulation, 1989; 80 (4 Suppl. 2) : II547. Conference Paper, Refereed, Presented, 06/1989.
  • Symons JD, Jacobs I. Force generation during repeated maximal muscle contractions is not impaired by low intramuscular glycogen. Medicine and Science in Sports and Exercise, 1988; 20 (2) : S26. Conference Paper, Refereed, Presented, 06/1988.
  • Hermiston AJ, Jacobs I, Symons JD.Comparison of exercise-induced and drug-induced acidosis on supramaximal exercise performance: 98. Medicine & Science in Sports & Exercise, 1987; 19 (2 Suppl.) : S17. Conference Paper, Refereed, Presented, 06/1987.
  • VanHelder T, Symons JD, Radomski MW. The effects of sleep deprivation and physical activity on insulin sensitivity and carbohydrate metabolism. Canadian Journal of Applied Sports Sciences. 12 (3). Conference Paper, Refereed, Presented, 06/1987.
  • Symons JD, Bell D, Pope J, vanHelder T, Myles WS. Electromechanical response times and rate of force development in males before and after sleep deprivation. Canadian Journal of Applied Sports Sciences. 12 (3). Conference Paper, Refereed, Presented, 06/1987.
  • VanHelder T, Symons JD, Radomski MW. The effects of sleep deprivation and daily physical activity on plasma growth hormone Canadian Journal of Applied Sports Sciences. 12 (3). Conference Paper, Refereed, Presented, 06/1987.
  • Symons JD, VanHelder T, Myles WS. Sleep deprivation and its effect on selected physical performance parameters: 38. Medicine & Science in Sports & Exercise, 1987; 19 (2) : S7. Conference Paper, Refereed, Presented, 06/1987.
  • Symons JD, Vigna S, and Evonuk E. The effect of chronic exercise on circulating levels of PGI2, high density lipoprotein, and total cholesterol. Canadian Journal of Applied Sports Sciences. 11 (3): 43P. Conference Paper, Refereed, Presented, 06/1986.
  • Kavanagh MF, Jacobs I, Pope J, Symons JD, Hermiston A. The effects of hypoxia on performance of the Wingate anaerobic power test. Canadian Journal of Applied Sports Sciences. 11 (3): 23P. Conference Paper, Refereed, Presented, 06/1986.
  • Symons JD. The effects of chronic exercise on prostacyclin (PGI↓ 2, Epoprostenol), high density lipoproteins (HDL), and total cholesterol (TC). Dissertation. 1985. Conference Paper, Refereed, Presented, 06/1985.
  • Symons JD, Agnew J, Evonuk E. The effect of chronic and acute exercise on ADP-induced aggregation times of blood platelets in rats. The Physiologist, 25 (4): 207. 9.7. Conference Paper, Refereed, Presented, 06/1982.

Research Groups

  • Molecular Medicine, Research Professor. 01/2014 - present.
  • Diabetes and Metabolism Center, Research Professor. 01/2013 - present.
  • Center on Aging, Research Professor. 01/2013 - present.

Grants, Contracts & Research Gifts

  • CHARACTERIZING THE PHENOTYPE OF YOUNG AND OLD MICE WITH DISRUPTED VASCULAR AUTOPHAGY. PI: SYMONS, JOHN DAVID. NATIONAL INSTITUTES OF HEALTH, 01/01/2017 - 12/31/2019. Total project budget to date: $149,000.00
  • CHARACTERIZING A MOUSE MODEL TO STUDY VASCULAR AUTOPHAGY IN OBESITY AND TYPE 2 DIABETES. PI: SYMONS, JOHN DAVID. UNIVERSITY OF UTAH, DIABETES AND METABOLISM CENTER, 01/01/2015 - 12/12/2016. Total project budget to date: $25,000.00
  • THE ROLE OF CERAMIDE IN OBESITY-RELATED VASCULAR DYSFUNCTION (R15HL091493). PI: SYMONS, JOHN DAVID. NATIONAL INSTITUTES OF HEALTH, 07/30/2008 - 07/31/2015. Total project budget to date: $660,844.00
  • Biological signatures of blueberry derived microbial metabolites. PI: Velayutham. 09/21/2018 - 08/20/2022. Total project budget to date: $260,756.00
  • Autophagy maintains vascular function through a novel glycolysis-linked pathway regulating eNOS. PI: Symons. 07/01/2018 - 05/31/2022. Total project budget to date: $300,571.00
  • Blueberry and healthy vascular aging. PI: Velayutham. 04/01/2018 - 03/30/2020. Total project budget to date: $75,000.00
  • Dietary strawberry prevents vascular inflammation. PI: Velautham. 03/01/2018 - present. Total project budget to date: $150,000.00
  • AUTOPHAGY MAINTAINS VASCULAR FUNCTION THROUGH A NOVEL GLYCOLYSIS-LINKED PATHWAY REGULATING ENOS. PI: SYMONS, JOHN DAVID. 07/01/2017 - 06/30/2022. Total project budget to date: $2,500.00
  • REPRESSED AUTOPHAGY IMPAIRS NITRIC OXIDE GENERATION BY HUMAN ENDOTHELIAL CELLS. PI: PARK, SEUL-KI. Co-PI(s): SYMONS, JOHN DAVID . AMERICAN HEART ASSOCIATION, 07/01/2017 - 06/30/2019. Total project budget to date: $103,000.00

Research/Scholarship Projects

  • Does gamma tocopherol supplementation lessen endothelial dysfunction in mice with type 2 diabetes? (University of Utah). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 12/2012 - 11/2013.
  • The role of ceramide in contributing to vascular dysfunction in diet-induced obesity. (NIH). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 08/2012 - 07/2016.
  • Mechanisms whereby endogenous ceramide impairs eNOS signaling and arterial function. (ADA). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 01/2012 - 12/2015.
  • Training in Metabolism (NIH). PI: E Dale Abel. Co-PI(s): J David Symons. 07/2011 - 06/2014.
  • Mechanisms for ceramide-mediated vascular dysfunction (University of Utah). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 07/2011 - 06/2012.
  • Ceramide binds I2PP2A and activates PP2A (University of Utah). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 06/2011 - 05/2012.
  • Reduction of blood pressure in hypertensive rats by feeding a high fat diet: mechanisms and metabolic effects (University of Utah). PI: T Jalili. Co-PI(s): J David Symons. 07/2010 - 06/2011.
  • Determination of reactive oxygen/nitrogen species in cell culture models of oxidant stress using electron paramagnetic spectroscopy (University of Utah). PI: J David Symons. 01/2010 - 12/2010.
  • Determining the contribution from ceramide to cardiovascular complications associated with obesity in Sptlcb2+ mice (University of Utah). PI: J David Symons. 07/2008 - 06/2010.
  • Role of ceramide in obesity-related vascular dysfunction (ADA). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 01/2008 - 01/2012.
  • The role of ceramide in contributing to vascular dysfunction in diet-induced obesity (NIH). PI: J David Symons. Co-PI(s): E Dale Abel, J Rutter. 01/2008 - 11/2011.
  • Ceramide contributes to vascular insulin resistance, vascular dysfunction, and systemic hypertension in diet-induced obesity (University of Utah College of Health). PI: J David Symons. 07/2007 - 06/2008.
  • Exercise-training increases nitric oxide bioavailability in insulin receptor null mice (AHA). PI: J David Symons. 01/2006 - 01/2008.
  • Mechanisms of the diabetic myocardial vulnerability (NIH). PI: S Litwin. Co-PI(s): J David Symons. 07/2005 - 06/2010.
  • Physical activity lessens ischemia-induced myocardial and coronary vascular dysfunction in diabetes (University of Utah College of Health). PI: J David Symons. 06/2004 - 05/2005.
  • Hardware/software to evaluate cardiac output in humans in ESS 4310/6310 laboratory (University of Utah). PI: J David Symons. 02/2004 - 02/2004.
  • Supplementing quercetin in the diet can prevent hypertension (University of Utah). PI: T Jalili. Co-PI(s): J David Symons. 07/2003 - 06/2004.
  • Coronary vascular function in mice with cardiac-selective deletion of the insulin receptor (University of Utah). PI: J David Symons. 01/2003 - 12/2004.
  • Hyperhomocysteinemia: Effects on arterial permeability, compliance, and lesion development in mice (AHA). PI: J David Symons. 01/2001 - 12/2005.

Languages

  • English, fluent.

Publications

  • Yang K (2019). Soluble (Pro)renin receptor as a potential therapy for diabetes insipidus. Am J Physiol, Renal Physiology. Published, 11/05/2019.
  • Pike D (2019). The effect of endothelial nitric oxide synthase on the hemodynamics and wall mechanics in murine arteriovenous fistulas. Scientific Reports. Accepted, 02/2019.
  • Park S-K (2019). Elevated arterial shear rate increases indices of endothelial cell autophagy and nitric oxide synthase activation in humans. Am J Physiol Heart Circ Physiol. Published, 01/2019.
  • C Petersen (2019). Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. J Nutritional Biochemistry. Published, 01/2019.
  • Petersen C (2018). Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice. Int J Cardiol. Published, 07/15/2018.
  • Bharat D (2018). Blueberry metabolites attenuate lipotoxicity-induced endothelial dysfunction. Mol Nutr Food Res. Published, 01/2018.
  • Yang K (2017). The soluble (pro)renin receptor does not influence lithium-induced diabetes insipidus but does provoke beiging of white adipose tissue in mice. Physiological Reports. Published, 11/2017.
  • Dey P (2017). Improved hepatic y-tocopherol status limits oxidative and inflammatory stress-mediated liver injury in db/db mice with nonalcoholic steatohepatits. Journal of Functional Foods. Published, 11/2017.
  • Hydren JR (2017). Are cardiovascular reflexes sensitive to subtle alterations in arterial waveform patterns?. Journal of Applied Physiology. Published, 10/15/2017.
  • Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, PVA Babu. Blueberry metabolites attenuate lipotoxicity-induced endothelial dysfunction. Mol nutr food res. 2017 Oct 12. PMID:29024402. Published, 10/12/2017.
  • Qian Y (2017). Metabolites of flavonoid compounds preserve indices of enothelial cell nitric oxide bioavailability under glucotoxic conditions. Nutr Diabetes. Published, 09/11/2017.
  • Qian Y, Babu PVA, Symons JD, Jalili T. Metabolites of flavonoid compounds preserve indices of enothelial cell nitric oxide bioavailability under glucotoxic conditions. Nutr diabetes. 2017 Sep 11; 7(9):e286. doi: 10.1038/nutd. 2017.34. PMID:28892039. Published, 09/11/2017.
  • Bharath LP, Cho JM, Park SK, Ruan T, Li YY, Mueller R, Bean T, Reese V, Richardson RS, Cai JJ, Sargsyan A, Pires K, Babu PVA, Boudina S, Graham TE, Symons JD. Endothelial cell autophagy maintains shear stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS. Arterioscler thromb vasc biol. 2017 37 (9) 1646-1656. PMID: 28684613. Published, 06/2017.
  • Pires KM (2017). Autophagy inhibition in (ob/ob) hears is mediated by mTOR signaling that may be independent of Akt. Journal of Molecular and Cellular Cardiology. Published, 01/2017.
  • Bharath LP (2017). Endothelial cell autophagy maintains shear stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS. Arterioscler Thromb Vasc Biol. Published, 01/2017.
  • Li Y (2016). y-Carboxyethyl hydroxychroman, a metabolite of γ−tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose. Experimental Biology and Medicine. Published, 12/2016.
  • Park S-Y & Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, and Riehle CM. (2016). Exercise-training improves vascular mitochondrial function. American Journal of Physiology, Heart and Circulatory Physiology. Published, 04/2016.
  • Park S-Y, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, and Riehle CM. Exercise-training improves vascular mitochondrial function. American journal of physiology, heart and circulatory physiology. Apr 2016; 1;310(7):H821-9. PMID: 26825520 PMCID: PMC4867356. Published, 04/2016.
  • Li Y, Bharath LP, Qian Y, Ruan T, Anandh Babu PV, Bruno RS, Symons JD, Jalili T. y-Carboxyethyl hydroxychroman, a metabolite of γ−tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose. Experimental biology and medicine (Maywood, N. J.). Dec 2016; 241(18):2056 2062. PubMed [journal] PMID: 27465143 PMCID: PMC5102138. Published, 01/2016.
  • Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK,Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. Ceramide-initiated protein phosphatase 2A activation contributes to arterial dysfunction in vivo. Diabetes. 2015; 64(11):3914-26. PubMed [journal] PMID:26253611 PMCID:PMC4613970. Published, 11/01/2015.
  • Park SY, Ives S, Gifford J, Andtbacka R, Hyngstrom J, Reese V, Layec G, Bharath LP, Symons JD, Richardson R. The impact of age on the vasodilatory function of human skeletal muscle feed arteries. American journal of physiology, heart and circulatory physiology. Nov 20, 2015. PIMD: 26589330. Published, 07/15/2015. Published, 07/15/2015.
  • Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman B, McClain D, O'Connell RM, Drummond MJ. MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. American journal of physiology. Endocrinology and metabollism. 2015; 309(1):E11-21. PubMed [journal] PMID: 25968578 PMCID:PMC4490331. Published, 07/01/2015.
  • Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Diabetes. 2015; 64(4):1180-92. PubMed [ journal] PMID: 2535263. Published, 04/2015.
  • Bharath LP, Mueller R, Li Y, Ruan T, Kunz D, Goodrich R, Mills T, Deeter L, Sargsyan A, Anandh Babu PV, Graham TE, Symons JD. Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.Canadian journal of physiology and pharmacology. 2014; 92(7):605-12. PubMed [journal] PMID: 24941409. Published, 07/2014.
  • Symons JD. Opportunity "nox" : a novel approach to preventing endothelial dysfunction in the context of insulin resistance. Diabetes. 2013 62(6):1818-1820. PubMed [journal] PMID:23704524 PMCID: PMC3661632. , 06/2013. Published, 06/2013.
  • Symons JD, Abel ED. Lipotoxicity contributes to endothelial dysfunction : a focus on the contribution from ceramide. Reviews in endocrine and metabolic disorders. 2013; 14(1) 59-68. NIHMSID: NIHMS433209 PubMed [journal] PMID: 23292334 PMCID: PMC4180664 , 06/2013. Published, 06/2013.
  • Bosse JD, Lin HY, Sloan C, Zhang Q, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T. A low-carbohydrate/high- fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. American journal of physiology. Heart and circulatory physiology.2013; 304 (12):H1733-1742. PubMed [journal] PMID 23604708 PMCID: PMC3680768 06/2013. Published, 06/2013.
  • Ives SJ, Andtbacka RH, Noyes RD, Morgan RG, Gifford J, Park SY, Symons JD, Richardson RS. Alpha 1-adrenergic responsiveness in human skeletal muscle feed arteries: the impact of reducing extracellular pH. Experimental physiology. 2013; 98(1) : 256-67. NIHMSID: NIHMS399422 PubMed [journal] PMID: 22798402. PMC4465408. Published, 06/2013.
  • Larson A, Witman M, Guo Y, Ives S, Richardson RS, Bruno RS, Jalili T, Symons JD. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide.Nutrition research (New York, N.Y.). 2012; 32(8): 557-64. PubMed [journal] PMID: 22935338. , 06/2012. Published, 06/2012.
  • Zhang Q, Holland W, Wilson L, Tanner J, Kearns D, Cahoon J, Pettey D, Losee J, Duncan B, Gale D, Kowalski C, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra K, Summers S, Abel E, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by pp2a-mediated dephosphorylation of the enos-akt complex. Diabetes. 2012 61 (7): 1848-59. PMID: 22586587. Published, 06/2012.
  • Miller CJ, Gounder SS, Kannan S, Goutam K, Muthusamy VR, Firpo MA, Symons JD, Paine R 3rd, Hoidal JR, Rajasekaran NS. Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. (2012). Biochimica et biophysica acta. 2012; 1822 (6):1038-50. PubMed [journal] PMID: 22366763. Published, 06/2012.
  • Wende AR, Symons JD, Abel ED. Mechanisms of lipotoxicity in the cardiovascular system. Current hypertension reports. 2012; 14(6):517-31. NIHMSID: NIHMS412642 PubMed [journal] PMID: 23054891 PMCID: PMC3491122. Published, 06/2012.
  • Larson A, Symons JD, Jalili T. Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanism. Advances in nutrition (Bethesda, Md.). 2012; 3 (1):39-46. PubMed [journal] PMID: 22332099 PMCID: PMC3262612. , 06/2012. Published, 06/2012.
  • Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE. Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. American journal of physiology. Heart and circulatory physiology. 2011; 300(1): H374 -81. PubMed [journal] PMID: 20971769. PMCID: PMC3023253. Published, 06/2011.
  • Ives SJ, Andtbacka RH, Noyes RD, McDaniel J, Amann M, Witman MAH, Symons JD, Wray DW, Richardson RS. Human skeletal muscle feed arteries studied in vitro: the effect of temperature on α(1)-adrenergic responsiveness. Experimental physiology. 2011; 96(9): 907-18.NIHMSID: NIHMS304488 PubMed [journal] PMID: 21685444 PMCID: PMC4465411. Published, 06/2011.
  • Singhal AK, Symons JD, Boudina S, Jaishy B, Shiu YT. Role of endothelial cells in myocardial ischemia-reperfusion injury. Vascular disease prevention. 2010; 7, 1-14. NIHMS ID: NIHMS635867 PubMed [journal] PMID: 25558187 PMCID: PMC4280830. Published, 07/2010.
  • Larson AJ, Symons JD, Jalili T. (2010) Quercetin: A treatment for hypertension? - A review of efficacy and mechanisms. pharmaceuticals 3 (1): 237-250. Published, 07/2010.
  • Tanner JM, Kearns DT, Kim BJ, Sloan C, Jia Z, Yang T, Abel ED, Symons JD. Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. Experimental biology and medicine (Maywood, N.J.). 2010; 235 (12): 1489-97. NIHMSID: NIHMS261854 PubMed [journal] PMID: 21127345 PMCID: PMC3367312. Published, 06/2010.
  • Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T. Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 2009 54(6):1321-7. NIHMSID: NIHMS161216 PubMed [journal] PMID:19884565 PMCID: PMC2803027. Published, 06/2009.
  • Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circulation research.2009; Vol. 104(9), 1085-1094. NIHMSID: NIHMS232601 PubMed [journal] PMID: 19342603 PMCID:PMC2936913. Published, 05/08/2009.
  • Zhang QJ, Mcmillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signaling kinases. The journal of physiology. 2009; 587(Pt 15):3911-3920. PubMed [journal] PMID: 19505983 PMCID: PMC22746618. Published, 01/2009.
  • Wang N, Symons JD, Zhang H, Jia Z, Gonzalez FJ, Yang T. Distinct functions of vascular endothelial and smooth muscle ppargamma in regulation of blood pressure and vascular tone. Toxicologic pathology. 2009. Vol. 37(1), 21-27.NIHMSID: NIHMS161514 PubMed [journal] PMID: 19075043 PMCID: PMC2791342. Published, 01/2009.
  • Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S, Symons JD, Schnermann JB, Gonzalez FJ, Litwin SE, Yang T.Vascular ppargamma controls circadian variation in blood pressure and heart rate through bmal1. Cell metabolism. 2008; 8(6): 482-91. PubMed [journal] PMID: 19041764. Published, 12/01/2008.
  • Liu H, Jia Z, Soodvilai S, Guan G, Wang MH, Dong Z, Symons JD, Yang T. Nitro-Oleic acid protects the mouse kidney from ischemia and reperfusion injury. American journal of physiology. Renal physiology. 2008; 295(4):F942-9. Pubmed [journal] PMID: 18753300 PMCID: PMC2576150. Published, 10/01/2008.
  • Pettitt RW, Symons JD, Taylor JE, Eisenman PA, White AT. Adjustment for gas exchange threshold enhances precision of heart rate-derived VO2 estimates during heavy exercise. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2008;33(1):68-74. PubMed [journal] PMID: 18347655. Published, 02/01/2008.
  • Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subject. The Journal of nutrition. 2007;137(11):2405-11. PubMed [journal] PMID: 17951477. Published, 11/01/2007.
  • Carlstrom J, Symons JD, Wu TC, Bruno RS, Litwin SE, Jalili T. A quercetin supplemented diet does not prevent cardiovascular complications in spontaneously hypertensive rats. Journal of nutrition. 2007; 137(3):628-33. PubMed [journal] PMID: 17311951. Published, 03/01/2007.
  • Symons JD, Zaid UB, Athanassious CN, Mullick AE, Lentz SR, Rutledge JC. Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia. Arteriosclerosis, thrombosis, vascular biology. 2006; 26(4): 814-8. PubMed [journal] PMID: 16424349. Published, 04/01/2006.
  • Mullick AE, Zaid UB, Athanassious CN, Lentz SR, Rutledge JC, Symons JD. Hyperhomocysteinemia increases arterial permeability and stiffness in mice. American journal of physiology . Regulatory, integrative and comparative physiology. 2006; 291(5):R1349-54. PubMed [journal] PMID: 16793933. Published, 01/2006.
  • Pettitt RW, Symons JD, Eisenman PA, Taylor JE, White AT. Eccentric strain at long muscle length evokes the repeated bout effect. Journal of strength & conditioning research. 2005; 19(4) : 918-24. PubMed [journal] PMID:16331873. Published, 06/2005.
  • Symons JD, Rutledge JC, Simonsen U, Pattathu RA. Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate. American journal of physiology. Heart and circulatory physiology. 2006; 290(1):H181-91. PubMed [journal] PMID:16424349. Published, 01/2005.
  • Ensunsa JL, Symons JD, Lanoue L, Schrader HR, Keen CL. Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Experimental biology and medicine (Maywood, N.J.). 2004; 229(11): 1143-53. PubMed [journal] PMID:15564441. Published, 12/30/2004.
  • Rendig SV, Symons JD, Amsterdam EA. Effects of statins on myocardial and coronary artery response to ischemia-reperfusion. Canadian journal of physiology and pharmacology. 2003; 81(11):1064-71. PubMed [journal] PMID: 14719042. Published, 11/01/2003.
  • Symons JD, Hayashi Y, Ensunsa JL. Improved coronary vascular function evoked by high-intensity treadmill training is maintained in arteries exposed to ischemia and reperfusion. Journal of applied physiology (Bethesa, Md. : 1985). 2003;95(4):1638-47. PubMed [ journal] PMID: 12819213. Published, 10/01/2003.
  • Stebbins CL, Symons JD, Hageman KS, Musch TI. Endogenous prostaglandins limit angiotensin-ii induced regional vasoconstriction in conscious rats. Journal of cardiovascular pharmacology. 2003; 42(1): 10-6. PubMed [journal] PMID: 12827020. Published, 07/01/2003.
  • Symons JD, Mullick AE, Ensunsa JL, Ma AA, Rutledge JC. Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function. Arteriosclerosis, thrombosis, and vascular biology. 2002; 22(5): 772-80. PubMed [journal] PMID:12006389. Published, 05/01/2002.
  • Musch TI, McAllister RM, Symons JD, Stebbins CL, Hirai T, Hageman KS, Poole DC. Effects of nitric oxide synthase inhibition on vascular conductance during high speed treadmill exercise in rats. Experimental physiology. 2001; 86(6), 749-57. PubMed [journal] PMID: 11698969. Published, 11/01/2001.
  • Symons JD, Gunawardena S, Kappagoda CT, Dhond MR. Volume overload left ventricular hypertrophy: effects on coronary microvascular reactivity in rabbits. Experimental physiology. 2001; 86(6): 725-32. PubMed [journal] PMID: 11698966. Published, 11/01/2001.
  • Symons JD, Schaefer S. Na(+)/H(+) exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium. American journal physiology. Heart and circulatory physiology. 2001; 281(4): H1575-82. PubMed [journall] PMID: 11557546. Published, 10/01/2001.
  • Rendig SV, Symons JD, Longhurst JC, Amsterdam EA. Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries. Journal of cardiovascular pharmacology 2001; 38(2): 219-27. PubMed [journal] PMID: 11483871. Published, 08/01/2001.
  • Symons JD,Rendig SV, Stebbins CL, Longhurst JC. Microvascular and myocardial contractile responses to ischemia: influence of exercise training. Journal of applied physiology (Bethesa, Md.: 1985). 2000; 88(2): 433-42. PubMed [journal] PMID: 10658008. Published, 02/01/2000.
  • Symons JD, Stebbins CL, Musch TI. Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats. Journal of applied physiology (Bethesda, Md.: 1985). 1999; 87(2):574-81. PubMed [journal] PMID: 10413076. Published, 08/01/1999.
  • Symons JD, Musch TI, Hageman KS, Stebbins CL. Regional blood flow responses to acute ANG II infusion: effects of nitric oxide synthase inhibition. Journal of cardiovascular pharmacology. 1999; 34(1):116-23. PubMed [journal] PMID: 10413077. Published, 07/01/1999.
  • Symons JD, Sun X, Flaim SF, Del Balzo U. Perflubron emulsion improves tolerance to low-flow ischemia in isolated rabbit hearts. Journal of cardiovascular pharmacology. 1999; 34(1):108-15. PubMed [journal] PMID:10413076. Published, 07/01/1999.
  • Guo ZL, Symons JD, Longhurst JC. Activation of visceral afferents by bradykinin and ischemia: independent roles of PKC and prostaglandins. The American journal of physiology. 1999; 276( 6 Pt 2): H1884-91. PubMed [journal] PMID: 10362667. Published, 06/01/1999.
  • Symons JD, Correa SD, Schaefer S. (1998) Na-H exchange inhibition with cariporide limits functional impairment caused by repetitive ischemia. Journal of cardiovascular pharmacology. 1998; 32(6):853-62. PubMed [journal] PMID: 9869490. Published, 12/01/1998.
  • Guo ZL, Fu LW, Symons JD, Longhurst JC. (1998) Signal transduction in activation of ischemically sensitive abdominal visceral afferents: role of PKC.The American journal of physiology. 1998; 275(3 Pt 2):H1024-31. PubMed [journal] PMID: 9724309. Published, 09/01/1998.
  • Symons JD, Rendig SV, Fu LW, Longhurst JC. Endothelin-1 limits increases in blood flow to native and collateral-dependent myocardium. The American journal of physiology. 1997; 273(1 Pt 2): R41-8. PubMed [journal] PMID: 9249531. Published, 07/01/1997.
  • Symons JD, Stebbins CL. Effects of angiotensin II receptor blockade during exercise: comparison of losartan and saralasin. Journal of cardiovascular pharmacology. 1996; 28(2):223-31. PubMed [journal] PMID:8856477. Published, 08/01/1996.
  • Symons JD, Stebbins CL. Hemodynamic and regional blood flow responses to nicotine at rest and during exercise. Medicine and science in sports and exercise. 1996; 28(4):457-67. PubMed [journal] PMID: 8778551. Published, 04/01/1996.
  • Symons JD and Stebbins CL. The role of vasopressin and angiotensin II in the hemodynamic response to dynamic exercise. Advances in experimental medicine and biology. 1995; 381:215-21. PubMed [journal] PMID: 8867837. Published, 06/1995.
  • Stebbins CL, Symons JD. (1995) Role of angiotensin II in hemodynamic responses to dynamic exercise in miniswine. Journal of applied physiology (Bethesda, Md.: 1985). 78(1):185-90. PubMed [journal] PMID: 7713810. Published, 01/01/1995.
  • Stebbins CL, Symons JD, McKirnan MD, Hwang FF. Factors associated with vasopressin release in exercising swine. The American journal of physiology. 1994; 266(1 Pt 2):R118-24. PubMed [journal] PMID: 8304532. Published, 01/01/1994.
  • Amsterdam EA, Pan HL, Rendig SV, Symons JD, Fletcher MP, Longhurst JC. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration. Journal of the American college of cardiology. 1993; 22(6):1738-44. PubMed [journal] PMID: 8227848. Published, 11/15/1993.
  • Symons JD, Firoozmand E, Longhurst JC. Repeated dipyridamole administration enhances collateral-dependent flow and regional function during exercise. A Role for adenosine. Circulation research. 1993; 73(3):503-13. PubMed [journal] PMID: 8348693. Published, 09/01/1993.
  • Eisele PH, Griffey SM, Kittleson MD, Wilkens EM, Symons JD, Longhurst JC. Localized pericardial effusion and right-sided heart tamponade: complications of cardiac surgery in a Hanford miniature pig. Laboratory animal science. 1993; 43(4):373-7. PubMed [journal] PMID: 8231101. Published, 08/01/1993.
  • Jacobs I, Hermiston AJ, Symons JD. Effects of prior exercise or ammonium chloride ingestion on muscular strength and endurance. Medicine and science in sports and exercise. 1993; 25(7):809-14. PubMed [journal] PMID: 8350703. Published, 07/01/1993.
  • Longhurst JC and Symons JD. Function and development of coronary collateral vessels. Collateral circulation. W Schaper and J Schaper (Eds). Kluwer Academic Publishers. 195-214. Published, 06/1993.
  • VanHelder T, Symons JD, Radomski MW. Effects of sleep deprivation and exercise on glucose tolerance. Aviation, space, and environmental medicine. 1993; 64(6): 487-92. PubMed [journal] PMID: 8338493. Published, 06/01/1993.
  • Symons JD, Longhurst JC, Stebbins CL. Response of collateral-dependent myocardium to vasopressin release during prolonged intense exercise. The American journal of physiology. 1993; 264(5 Pt 2):H1644-52. PubMed [journal] PMID: 7684576. Published, 05/01/1993.
  • Stebbins CL, Symons JD. Vasopressin contributes to the cardiovascular response to dynamic exercise. American journal of physiology. 1993; 264(5 Pt 2): H1701-7. PubMed [journal] PMID: 8498582. Published, 05/01/1993.
  • Pitsillides KF, Symons JD, Longhurst JC. Biotelemetry of cardiovascular hemodynamic measurements in miniswine. IEEE transactions on bio-medical engineering. 1992; 39(9): 982-6 PubMed [journal] PMID: 1473828. Published, 09/01/1992.
  • Symons JD, Pitsillides KF, Longhurst JC. Chronic reduction of myocardial ischemia does not attenuate coronary collateral development in miniswine. Circulation. 1992; 86(2); 660-71. PubMed [journal] PMID: 1638730. Published, 08/01/1992.
  • Pitsillides KF, Symons JD, Longhurst JC. Analysis of beat-to-beat cardiovascular hemodynamic variables obtained from long-term biotelemetry. Computer methods and programs in biomedicine. 1992; 37(3): 169-77. PubMed [journal] PMID: 1511601. Published, 04/01/1992.
  • Symons JD, Theodossy SJ, Longhurst JC, Stebbins CL. Intramuscular accumulation of prostaglandins during static contraction of the cat triceps surae. Journal of applied physiology (Bethesda, Md.: 1985). 1991; 71(5):1837-42. PubMed [journal] PMID: 1761481. Published, 11/01/1991.
  • Stahl GL, Amsterdam EA, Symons JD, Longhurst JC. Role of thromboxane A2 in the cardiovascular response to intracoronary C5a. Circulation research. 1990; 66(4): 1103-11. PubMed [journal] PMID: 2107984. Published, 04/01/1990.
  • Symons JD. Longitudinal and cross-sectional studies of the relationship between 6-keto PGF1 alpha and high density lipoproteins. Prostaglandins, leukotrienes, and essential fatty acids. 1990; 39(2):159-65. PubMed [journal] PMID: 2111556. Published, 02/01/1990.
  • Symons JD, Jacobs I. High-intensity exercise performance is not impaired by low intramuscular glycogen. Medicine and science in sports and exercise. 1989; 21(5): 550-7. PubMed [journal] PMID: 2691816. Published, 10/01/1989.
  • Symons JD, Bell DG, Pope J, VanHelder T, Myles WS. Electro-mechanical response times and muscle strength after sleep deprivation. Canadian journal of sport sciences. 1988; 13(4): 225-30. PubMed [journal] PMID: 3219670. Published, 12/01/1988.
  • Symons JD, VanHelder T, Myles WS. Physical performance and physiological responses following 60 hours of sleep deprivation. Medicine and science in sports and exercise. 1988; 20(4):374-80. PubMed [journal] PMID: 3173045. Published, 08/01/1988.
  • Symons JD, Jacobs I. Force generation during repeated maximal contractions is not impaired by low intramuscular glycogen. (pp. S26). Medicine and science in sports and exercise. Published, 01/01/1988.
  • Hermiston A, Jacobs I, Symons JD. Comparison of exercise-induced and drug-induced acidosis on supramaximal exercise performance. (pp. S17). Medicine and science in sports and exercise. Published, 01/01/1987.
  • VanHelder T, Symons JD, Radomski MW. The effects of sleep deprivation and physical activity on insulin sensitivity and carbohydrate metabolism. Canadian journal of applied sport sciences. Published, 01/01/1987.
  • VanHelder T, Symons JD, Radomski MW. The effects of sleep deprivation and daily physical activity on plasma growth hormone. Canadian journal of applied sport sciences. Published, 01/01/1987.
  • Symons JD, Bell D, Pope J, VanHelder T, Myles WS. Electro-mechanical response times and rate of force development in males before and after sleep deprivation. Canadian journal of applied sport sciences. Published, 01/01/1987.
  • Symons JD, VanHelder T, Myles WS. Sleep deprivation and its effect on selected physical performance parameters. (pp. S7). Medicine and science in sports and exercise. Published, 01/01/1986.