CHRISTIAN C YOST portrait
  • Professor, Pediatrics
  • Assistant Professor, Pediatrics
801-587-7493

Research Statement

Dr. Yost's research interests include the study of regulatory mechanisms governing the acute inflammatory response in newborn infants, both term and preterm, as it relates to syndromes of dysregulated inflammation such as necrotizing enterocolitis, neonatal chronic lung disease, and early onset sepsis. He has received extramural funding to examine translational regulation of protein expression via the mammalian target of rapamycin (mTOR) signaling cascade in neonatal PMNs. As part of this effort, his research team recently described for the first time a novel deficiency of innate immunity in newborn infants leading to an increased risk of infection in term and preterm infants - failure of neutrophil extracellular trap (NET) formation with decreased extracellular killing of bacteria. Dr. Yost’s research efforts currently focus on elucidating the regulatory mechanisms governing NET formation by human PMNs and the role of dysregulated NET formation in the inflammatory syndromes associated with prematurity.

Presentations

  • "NET inhibition in SARS-CoV-2 infection," Oral Presentation at the Neutrophils in COVID-19 Virtual Banbury Meeting sponsored by Cold Spring Harbor Laboratory and the "NETwork to target neutrophils in COVID-19". , Presented, 2020.
  • NETs as Friends or Foes: Lessons from Human Neonates and Translational Models State of the Art Speaker - Rheumatology/Immunology Western Section "American Federation for Medical Research (WAFMR) Carmel, CA. , Presented, 2018.
  • Regulation and Dysregulation of Neutrophil Extracellular Traps: Lessons from Human Neonates and Translational Models Within the session entitled "New Insights into the Neonatal Inflammatory Response: Implications for Transfusion Medicine" American Association of Blood Banks National Meeting, San Diego, CA. , , 2017.
  • Expert Interview - NETs as Friends or Foes Video Interview Requested by the Education Committee of the European Hematology Association Recorded at the National Meeting of the American Society for Hematology, Atlanta, GA Interviewer: Shaun R. McCann. , , 2017.
  • NETs as Friends of Foes: Lessons from Human Neonates and Translational Models within the Educational Spotlight Session entitled "A Sticky Business: New Insights into Neutrophil Extracellular Traps (NETs) in Physiology and Disease American Society for Hematology National Meeting, Atlanta GA. , , 2017.
  • Regulation and Dysregulation of Neutrophil Extracellular Traps: Lessons from Human Neonates and Translational Models Department of Pediatrics Hematology/Oncology Seminar Series, Harvard Medical School/Boston Children's Hospital, Boston, MA. , , 2017.
  • Neonatal NET-Inhibitory Factor (nNIF): A Novel Endogenous Regulator of NETs Neutrophil 2014 International Conference, Montreal, CA. , , 2014.
  • Neutrophil Extracellular Trap Formation: Bedside to Bench and Back Again 31st Conference on High Frequency Ventilation of Infants, Children and Adults Snowbird, UT. , , 2014.
  • Impaired Neutrophil Extracellular Trap (NET) Formation: A Novel Innate Immune Deficiency of Human Neonates. , , 2011.
  • "Neutrophil extracellular traps - Newly recognized PMN biology pertinent to newborns" 24th Conference on High Frequency Ventilation of Infants, Children and Adults, Snowbird, UT. , , 2007.
  • "Differential Gene Expression in PAF-stimulated PMNs Isolated from Preterm Neonatal Cord Blood", University of Utah Pediatric Research Conference, SLC, UT. , , 2005.
  • "Management of the Pediatric Patient with Necrotizing Enterocolitis", Infusion Nurses Society Annual Meeting, Salt Lake City, UT. , , 2004.
  • Yost CC, McIntyre TM, Zimmerman GA, Weyrich AS, Marathe GK. Stimulation of Human Polymorphonuclear Leukocytes with Platelet Activating Factor Induces Cyclooxygenase-2. Poster session presented at 8th International Congress on Platelet Activating Factor. Poster, Presented, 2004.

Grants, Contracts & Research Gifts

  • NETosis in Human COVID-19 Disease. PI: - 2021. Total project budget to date:
  • Selection of a Lead Candidate for the Development of a Novel Anti-Inflammatory Therapeutic. PI: - 2021. Total project budget to date:
  • Advancing Neutrophil Targeting Peptides as a New Treatment for COVID-19. PI: - 2020. Total project budget to date:
  • Pro-Tumor Functions of Neutrophils in Squamous Cell Lung Cancer. PI: - 2024. Total project budget to date:
  • NETs: Protection Or Harm in Neonatal Inflammation and Infection R01HD93826. PI: - 2023. Total project budget to date:
  • USTAR Technology Acceleration Grant. PI: - 2019. Total project budget to date:

Languages

  • English, Fluent.
  • German, Fluent.

Publications

  • Yost CC, Bloom RS. (date unknown). Neonatal Resucitation. Accepted, .
  • Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen RD (date unknown). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. (pp. 532-535). Vol. 117. Accepted, .
  • Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA (date unknown). Neutrophil Cathepsin G Proteolysis of Protease Activated Receptor 4 Generates a Novel, Functional Tethered Ligand. Accepted, .
  • Morales-Ortíz J, Deal V, Reyes F, Maldonado-Martínez G, Ledesma N, Staback F, Croft C, Pacheco A, Ortiz-Zuazaga H, Yost CC, Rowley JW, Madera B, John AS, Chen J, Lopez J, Rondina MT, Hunter R, Gibson A, Washington AV (date unknown). Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Vol. 132, 2495-2505. Accepted, .
  • McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung CM (date unknown). Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. Vol. 47, 634-43. Accepted, .
  • Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (date unknown). Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. Vol. 7, e1002355. Accepted, .
  • McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW, Rondina MT, Yost CC (date unknown). Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α. Vol. 120, 3118-25. Accepted, .
  • Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (date unknown). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Vol. 118, e101-11. Accepted, .
  • Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (date unknown). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. Vol. 126, 3783-3798. Accepted, .
  • MacQueen BC, Christensen RD, Yost CC, Gordon PV, Baer VL, Schlaberg R, Lowe J (date unknown). Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis. Vol. 38, 1379-1385. Accepted, .
  • MacQueen BC, Christensen RD, Yost CC, Lambert DK, Baer VL, Sheffield MJ, Gordon PV, Cody MJ, Gerday E, Schlaberg R, Lowe J, Shepherd JG (date unknown). Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps. Vol. 36, 862-9. Accepted, .
  • Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (date unknown). Platelet gene expression and function in patients with COVID-19. Vol. 136, 1317-1329. Accepted, .
  • Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman GA (date unknown). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. Vol. 200, 671-80. Accepted, .
  • Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (date unknown). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Vol. 136, 1169-1179. Accepted, .
  • Murphy J, Yost CC, Short S, Alashari M, Chan B. (date unknown). Black eschar on a 4 day old preterm infant. Vol. 19, e564-e568. Accepted, .
  • Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS (date unknown). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Vol. 122, 379-91. Accepted, .
  • McKnight RA, Yost CC, Zinkhan EK, Fu Q, Callaway CW, Fung CM (date unknown). Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Vol. 48, 616-25. Accepted, .
  • Denorme F, Rustad JL, Portier I, Crandell JL, de Araujo CV, Cody MJ, Campbell RA, Yost CC (date unknown). Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis. Accepted, .
  • Yost CC (date unknown). Pediatric immunothrombosis-Understudied… but what potential!. Vol. 86, 17-18. Accepted, .
  • Brunelli L, Jenkins SM, Gudgeon JM, Bleyl SB, Miller CE, Tvrdik T, Dames SA, Ostrander B, Daboub JAF, Zielinski BA, Zinkhan EK, Underhill HR, Wilson T, Bonkowsky JL, Yost CC, Botto LD, Jenkins J, Pysher TJ, Bayrak-Toydemir P, Mao R (date unknown). Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants. Vol. 7, e00796. Accepted, .
  • Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (date unknown). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Vol. 86, 55-62. Accepted, .
  • Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost CC (date unknown). Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide. Accepted, .
  • Glenn JW, Cody MJ, McManus MP, Pulsipher MA, Schiffman JD, Yost CC (date unknown). Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation. Vol. 7, 250. Accepted, .
  • Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (date unknown). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Vol. 113, 6419-27. Accepted, .
  • Yang MJ, Fenton S, Russell K, Yost CC, Yoder BA (date unknown). Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO?. Vol. 40, 935-942. Accepted, .
  • Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M (date unknown). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. Vol. 217. Accepted, .
  • Yost CC, Weyrich AS, Zimmerman GA (date unknown). The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Vol. 92, 692-7. Accepted, .
  • Bloom R, Yost CC (date unknown). A consideration of neonatal resuscitation. Vol. 51, 669-84, ix. Accepted, .
  • Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung DT (date unknown). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Vol. 8, ofab237. Accepted, .
  • Lindemann SW, Yost CC, Denis MM, McIntyre TM, Weyrich AS, Zimmerman GA (date unknown). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Vol. 101, 7076-81. Accepted, .
  • Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK (date unknown). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. Vol. 109, 915-930. Accepted, .
  • Yost CC (date unknown). Toward the "ideal" inhibitor of NETs. Vol. 123, 2439-40. Accepted, .
  • Araújo CV, Campbell C, Gonçalves-de-Albuquerque CF, Molinaro R, Cody MJ, Yost CC, Bozza PT, Zimmerman GA, Weyrich AS, Castro-Faria-Neto HC, Silva AR (date unknown). A PPARγ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS. Vol. 45, 393-403. Accepted, .
  • Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell RA (date unknown). Neutrophil extracellular traps regulate ischemic stroke brain injury. Accepted, .
  • Yost CC (date unknown). Neonatal necrotizing enterocolitis: diagnosis, management, and pathogenesis. Vol. 28, 130-4. Accepted, .
  • Cox KJ, Yang MJ, Fenton SJ, Russell KW, Yost CC, Yoder BA (date unknown). Operative repair in congenital diaphragmatic hernia: How long do we really need to wait?. Accepted, .
  • Yost CC (date unknown). Neutrophils clear sterile inflammatory debris. Vol. 137, 293-294. Accepted, .
  • Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell RA (date unknown). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Vol. 41, 401-414. Accepted, .
  • Thornton NL, Cody MJ, Yost CC (date unknown). Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. Vol. 101, 140-6. Accepted, .
  • Yost CC, Soll RF (date unknown). Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. CD001456. Accepted, .