JEFFREY SCOTT HALE portrait
  • Assistant Professor, Pathology
801-587-1885

Research Statement

My laboratory studies T cells and their role in the generation of immunological memory in response to viral infection and immunization. Upon activation, naïve CD4+ T cells proliferate and differentiate to become distinct types of T helper cell subsets that have specialized effector functions that are tailored to protect the host against the specific type of invading pathogen. During acute viral infection, newly activated CD4+ T cells differentiate into two functionally distinct T helper cell subsets: 1) Th1 cells that secrete IFNγ and contribute to cell-mediated immunity; and 2) Follicular helper T cells (Tfh) that migrate to B cell follicles and provide critical help to germinal center B cells and the generation of long-lived antibody responses. Following viral clearance, these subsets of T helper cells can become long-lived memory T cells that are poised to rapidly respond to reinfection by recalling their effector functions. Our studies focus on understanding the signals and mechanisms that promote the differentiation of these functionally unique subsets of effector and memory T cells and determine how these cells can be utilized to improve protective immune responses. We utilize various models of infection and vaccination in mice to study the basic mechanisms of T cell differentiation and function. We take advantage of mouse knockout and conditional knockout models to understand how transcription factors and epigenetic regulators modulate the gene expression programing and function of pathogen-specific effector and memory T cell subsets. Understanding how T cells acquire and maintain their specialized functions will provide important insights that can be used to improve prime and boost vaccination strategies to generate long-lived protective immunity against infectious diseases.

Presentations

  • Hale JS. Epigenetic Programing of virus-specific helper T cells. University of Utah Bioscience Symposium, Salt Lake City, Utah. , , 2018.
  • Hale JS. Epigenetic control of follicular helper T cell differentiation. Hematology Faculty Conference, Huntsman Cancer Institute, Salt Lake City, UT. , , 2018.
  • Hale JS. Finding my way as an academic scientist and doing some immunology along the way. University of Utah, Bioscience Undergraduate Research Program, Lecture to BioURP students as an alumnus of this program, Salt Lake City, UT. , , 2016.
  • Hale JS. Epigenetic programming of virus-specific memory helper T cells. Brigham Young University, Department of Microbiology and Molecular Biology, Departmental Seminar, Provo, UT. , , 2016.
  • Hale JS. Helper T cell differentiation and viral immunity. University of Utah, Molecular Biology Program, FRIS Presentation to 1st Year Graduate Students, Salt Lake City, UT. , , 2016.
  • Hale JS. CD4 T helper cell differentation in response to viral infection. University of Utah, Office of Comparative Medicine, Monthly Lunch and Learn Presentation, Salt Lake city, UT. , , 2016.
  • Hale JS. Helper T cell and memory T cell differentiation and viral immunity. University of Utah, Molecular Biology Program, FRIS Presentation to 1st Year Graduate Students, Salt Lake City, UT. , , 2015.
  • Hale JS, Helper T cells: Roles in acute and chronic viral infections, 2013 Summer Symposium on Immunological Mechanisms, Midway, UT. , , 2013.
  • Hale JS, Helper T cells: Roles in acute and chronic viral infections, The Third Military Medical University, Chongqing, China. , , 2013.
  • Hale JS, Helper T cells: Roles in acute and chronic viral infections, Southwestern University (China), Chongqing, China. , , 2013.
  • Hale JS. Targeting DNA methyltransferases to modulate helper T cell differentiation. Microbiology and Immunology Summer Retreat 2018, University of Utah, Park City, UT. , , 2018.
  • Hale JS. Recent progress in T follicular helper cell biology: Memory Tfh cells and epigenetic programing, American Society of Transplantation sponsored symposium at the AAI 2018 Meeting, Austin, Texas, United States of America. , , 2018.
  • Hale JS. Epigenetic programming of virus-specific memory helper T cells. University of Utah Department of Pathology, 4th Annual Immunology, Inflammation, and Infectious Diseases Summer Symposium. Park City, UT. , , 2016.
  • Hale JS. Tbet suppresses Th17 differentiation during acute viral infection. American Association of Immunologists, Immunology 2016, Seattle, Washington, United States of America. , , 2016.
  • Hale JS, Modulating CD4 T helper cell regulation to enhance antibody responses to an HIV immunogen, CHAVI-ID Research Focus #2 Meeting, Atlanta, GA. , , 2014.
  • Hale JS, CD4 T helper cell responses to an HIV envelope immunogen, 2014 CHAVI-ID All Investigators Retreat, La Jolla, CA. , , 2014.
  • Hale JS, Memory T Follicular Helper Cells, 2013 CHAVI-ID All Investigators Retreat, La Jolla, CA. , , 2013.
  • Hale JS, Distinct memory CD4 T cells with commitment to the T follicular helper and Th1 lineages, 2012 CHAVI-ID Research Focus 2 Meeting, La Jolla, CA. , , 2012.
  • Hale JS, Distinct memory CD4 T cells with commitment to the T follicular helper and Th1 lineages, Viral Immunity Keystone Symposium, Keystone, CO. , , 2012.
  • Hale JS, Conditional deletion of Rag in peripheral T cells selects against TCR revision-prone T cells, Summer FASEB Meeting, Tuscon, AZ. , , 2007.
  • Hale JS, Transcriptional Regulation of the Pactolus Gene, 17th National Conference of Undergraduate Research, Salt Lake City, UT. , , 2003.

Languages

  • English, Fluent.

Publications

  • Trivedi S, Labuz D, Anderson CP, Araujo CV, Blair A, Middleton EA, Jensen O, Tran A, Mulvey MA, Campbell RA, Hale JS, Rondina MT, Leung DT (date unknown). Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. Vol. 9. Accepted, .
  • Baessler A, Hale JS (date unknown). Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity. Vol. 40, 377-379. Accepted, .
  • Jensen O, Trivedi S, Meier JD, Fairfax KC, Hale JS, Leung DT (date unknown). A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa. Vol. 7, eabe8931. Accepted, .
  • Olatunde AC, Hale JS, Lamb TJ (date unknown). Cytokine-skewed Tfh cells: functional consequences for B cell help. (pp. 536-550). Vol. 42. Accepted, .