SARAH FRANKLIN portrait
  • Adjunct Associate Professor, Department Of Biochemistry
  • Associate Professor, Internal Medicine
  • Adjunct Assistant Professor, Biochemistry Research
  • Assistant Professor, Internal Medicine
801-581-5029

Presentations

  • “Proteomic analyses of chromatin in heart failure” International Society for Heart Research North American Section, Halifax, Nova Scotia. , , 2018.
  • “Transitioning to a successful career in Cardiovascular Medicine & Research” International Symposium on Experimental and Clinical Cardiology, Athens, Greece. , , 2018.
  • “Utilizing U-CARS to probe the human proteome” Utah Cardiac Recovery Symposium, University of Utah, Salt Lake City, UT. , , 2017.
  • “Chromatin and Epigenetic Regulation of Cardiac Development” American Heart Association Scientific Sessions, Anaheim, CA. , , 2017.
  • “Chromatin Biology in Cardiac Stress” International Society for Heart Research, North American Section, New Orleans, LA. , , 2017.
  • “Epigenetic Regulation Driving Cardiac Morphology and Physiology” Gordon Research Conference, Colby-Sawyer College, New London, NH. , , 2016.
  • “Epigenetic Regulation Driving Cardiac Morphology and Physiology” Temple University, Philadelphia, PA. , , 2016.
  • “Epigenetic Regulation Driving Cardiac Morphology and Physiology” International Society for Heart Research World Congress, Buenos Aires, Argentina. , , 2016.
  • “Epigenetic mechanisms underlying physiological and morphological adaptations in heart disease” Utah Cardiac Recovery Symposium, University of Utah, Salt Lake City, UT. , , 2015.
  • “Remodeling of Histone Modifications in Cardiac Hypertrophy and Failure” NHLBI Proteomics Seminar, Seattle, WA. , , 2015.
  • “Targeted Remodeling of Cardiac Histone Modifications to Regulate Hypertrophy and Failure” International Society for Heart Research, North American Section Conference, Miami, FL. , , 2014.
  • “Why chromatin structure matters: Proteomics and genomics reveal novel targets of heart failure” European Society of Cardiology Congress, Barcelona Spain. , , 2014.
  • “Proteomic Characterization of Chromatin-Binding Proteins Regulating Gene Expression in Heart Disease” Brigham Young University, Provo, UT. , , 2013.
  • “The Histone Methyltransferase Smyd1 Regulates Cardiac Hypertrophy in Adult Myocardium” American Heart Association Scientific Sessions, Dallas, TX. , , 2013.
  • “Chromatin Remodeling in the Failing Heart” American Heart Association Scientific Sessions, Dallas, TX. , , 2013.
  • “Proteomic identification of proteins driving chromatin remodeling in cardiac hypertrophy and failure” Biochemistry Department, Colorado State University, Fort Collins, Colorado. , , 2012.
  • “Nucleolar proteins controlling cardiac phenotype in rat myocytes and zebrafish revealed by chromatin proteomics” American Heart Association’s BCVS Conference, New Orleans, LA. , , 2012.
  • “Chromatin Structural Proteins: Remodeling the Genome for Heart Failure” American Heart Association Annual Conference, Los Angeles, CA. , , 2012.
  • “Systems analysis of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes” International Society for Heart Research, Banff, Alberta, Canada. , , 2012.
  • “Landscape of core nucleosomal histone post-translational modifications in heart failure” Human Proteome Organization World Congress, Boston, MA. , , 2012.
  • “Identification and Validation of Protein Modules Driving Chromatin Remodeling in Cardiac Hypertrophy and Failure” American Heart Association Annual Conference, Orlando, FL. , , 2011.
  • “Chromatin Remodeling During Cardiac Hypertrophy and Failure” Colorado Biological Mass Spectrometry Society, Denver, CO. , , 2011.
  • “Chromatin Remodeling during Cardiac Hypertrophy and Failure” Cardiovascular Research & Training Institute and Department of Physiology, University of Utah, Salt Lake City, UT. , , 2011.
  • “Chromatin Remodeling during Cardiac Hypertrophy and Failure” Department of Physiology, University of Arizona, Tucson, AZ. , , 2011.
  • “Chromatin Remodeling During Cardiac Hypertrophy and Failure” Colorado Biological Mass Spectrometry Society, Denver, CO. , , 2011.
  • “Histone dynamics during cardiac hypertrophy and failure: disease-induced chromatin remodeling,” Human Proteome Organization’s World Congress, Sydney, Australia. , , 2010.
  • “Discovery of novel histone regulation during cardiac hypertrophy” Gene Regulation Seminar Series, UCLA, Los Angeles, CA. , , 2010.
  • “Proteomic Analysis of Nuclear Signatures in Cardiac Hypertrophy and Failure,” Department of Biological Sciences, California State Polytechnic University, Pomona, CA. , , 2010.
  • “Proteomic Analysis of Nuclear Signatures in Cardiac Hypertrophy and Failure,” Department of Physiology, UCLA, Los Angeles, CA. , , 2009.
  • “Accurate Mass, High Resolution Mass Spectrometry in Conjunction with ETD for Analysis of Cardiac Signal Transduction.” Proteomics Symposium, University of Southern California, Los Angeles, CA. , , 2008.
  • “Intramolecular Interactions Within Voltage / Ca2+ Gated K+ Channels: Structure/Function Implications.” HUPO 7th Annual World Congress, Amsterdam, Netherlands. , , 2008.
  • “Protein Interactions and Post-translational Modifications in Cardiovascular Disease: A Systems Biology Approach,” Peptide & Protein Based Therapeutics Meeting, Cambridge Health Institute, San Diego, CA. , , 2008.
  • “Protein Oxidation and Macular Degeneration” Department of Anesthesiology, UCLA, Los Angeles, CA. , , 2006.
  • “Protein Oxidation and Macular Degeneration” Division of Cancer Treatment and Diagnosis, NIH, Bethesda, MD. , , 2006.
  • “Protein Oxidation and Macular Degeneration” Department of Medicine, UCSF, San Francisco, CA. , , 2006.
  • Protein Oxidation and Macular Degeneration” Department of Molecular Biology, Case Western, Cleveland, OH. , , 2006.
  • Shibayama J, Tracy C, Makaju A, Yuzyuk TN, Cox J, Wang L, Sabry A, Cawley K, Barton DW, Zaitsev AV, Franklin S. The Histone Methyltransferase Smyd1 Regulates Mitochondrial Energetics in Cardiomyocytes. Poster session presented at Keystone Symposium - Mitochondria, Metabolism and Heart, Santa Fe, NM. Poster, Presented, 2017.
  • Shibayama J, Sabry A, Cawley K, Makaju A, Cox J, Nix D, Zaitsev AV, Franklin S. Smyd1 is an Essential Regulator of Adaptive Response to Glucose Starvation in Cardiomyocytes. Poster session presented at BCVS Conference, Portland, OR. Poster, Presented, 2017.
  • Miller M, Li CC, Anderson A, Wang L, Smale ST, Franklin S. The histone methyltransferase Smyd5 is a novel regulator of cardiac hypertrophy. Poster session presented at Cold Spring Harbor – Epigenetics and Chromatin, Long Island, NY. Poster, Presented, 2016.
  • Anderson A, Miller M, Wang L, Franklin S. Smyd5 Regulates Hypertrophic Growth in the Heart. Poster session presented at Experimental Biology Meeting, San Diego, CA. Poster, Presented, 2016.
  • Tracy CM, Russell K, Denning K, Franklin S. Smyd1 Interactome in Skeletal and Cardiac Myocytes and Its Involvement in Novel Cellular Functions. Poster session presented at HUPO World Congress, Vancouver, Canada. Poster, Presented, 2015.
  • Makaju A, Fulcher J, Hicken, B, Franklin S. An Unbiased Approach for Identifying Novel Histone Methyltransferase Targets. Poster session presented at Keystone Epigenomics Meeting, Keystone Colorado, CO. Poster, Presented, 2015.
  • Miller M, Anderson A, Wang L, Li CC, Smale ST, Franklin S. The histone methyltransferase Smyd5 regulates cardiac hypertrophy. Poster session presented at ISHR Conference, Seattle, WA. Poster, Presented, 2015.
  • Makaju A, Franklin S. Identification of Cofactors influencing Smyd1’s Histone Methyltransferase Activity via ChIP-MS. Poster session presented at HUPO World Congress, Vancouver, Canada. Poster, Presented, 2015.
  • Miller M, Li CC, Anderson A, Wang L, Smale ST, Franklin S. Regulation of cardiac hypertrophy by the histone methyltransferase Smyd5. Poster session presented at American Heart Association Scientific Sessions Conference, Anaheim, CA. Poster, Presented, 2015.
  • Makaju A, Miller M, Wang L, Franklin S. Post-translational Modification of Histone Variants in Cardiac Hypertrophy. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, Las Vegas, NV. Poster, Presented, 2014.
  • Parvatiyar MS, López TD, Franklin S, Vondriska TM. Distinctive Roles of Linker Histone H1 Variants in the Hypertrophic Response of Cardiomyocytes. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, Las Vegas, NV. Poster, Presented, 2013.
  • Monte E, Mouillesseaux K, Chen H, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S. A Dual Role for Nucleolin Identified by Systems Analysis of Cardiac Chromatin Remodelers. Poster session presented at Experimental Biology, Boston, MA. Poster, Presented, 2013.
  • Monte E, Rosa-Garrido M, Chen H, Karbassi E, Franklin S, Vondriska TM. High Mobility Group Proteins Regulate Loss of Specialized Cardiac Myocyte Chromatin Features in Disease. Poster session presented at Keystone Conference: Epigenetic Marks and Cancer Drugs, Santa Fe, NM. Poster, Presented, 2013.
  • Franklin S, Chen H, Karbassi E, Monte E, Vondriska TM. Systems Epigenomics of Chromatin Structure in the Heart. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, New Orleans, LA. Poster, Presented, 2012.
  • Franklin S, Monte E, Mouillesseaux K, Ren S, Wang Y, Chen J, Vondriska TM. Systems analysis of cardiac chromatin reveals novel roles of chromatin structural proteins in cardiac development and disease. Poster session presented at Keystone Conference: Chromatin Dynamics, Keystone, CO. Poster, Presented, 2012.
  • Monte E, Mouillesseaux K, Chen H, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S. Nucleolar proteins controlling cardiac phenotype in rat myocytes and zebrafish revealed by chromatin proteomics. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, New Orleans, LA. Poster, Presented, 2012.
  • Franklin S, Chen H, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM. Loss of HMGB2 induces chromatin remodeling and hypertrophic growth in cardiomyocytes. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, New Orleans, LA. Poster, Presented, 2011.
  • Franklin S, Monte E, Chen H, Parvatiyar M, Ren S, Wang Y, Vondriska TM. Reprogramming cardiac gene expression and phenotype through altered stoichiometry of non-nucleosomal chromatin structural proteins. Poster session presented at American Heart Association Annual Conference, Orlando, FL. Poster, Presented, 2011.
  • Franklin S, Chen H, Mitchell-Jordan S, Ren S, Ping P, Wang Y, Abdellatif M, Vondriska TM. Hypertrophy alters expression of cardiac histones: remodeling chromatin for disease. Poster session presented at AHA Basic Cardiovascular Sciences Meeting, Rancho Mirage, CA. Poster, Presented, 2010.
  • Vondriska TM, Franklin S, Mitchell-Jordan S, Ren S, Chen H, Wang Y. Cardiac hypertrophy induces reprogramming of chromatin proteins: implications for novel therapeutics. Poster session presented at American Society of Anesthesiologists, Long Beach, CA. Poster, Presented, 2010.
  • Franklin S, Ren S, Wang Y, Vondriska TM. “Mechanistic Insights into Nuclear Protein Modules Responsible for Transcriptional Regulation in the Mammalian Heart”. Poster session presented at Keystone Conference on Chromatin Structure and Regulation, Taos, NM. Poster, Presented, 2010.
  • Franklin S, Mitchell-Jordan S, Chen H, Ren S, Ping P, Wang Y, Zhang M, Vondriska TM. Subcompartments of the nucleus are differentially modulated during the development of cardiac hypertrophy and failure in the mouse. Poster session presented at American Heart Association Annual Conference, Chicago, IL. Poster, Presented, 2010.
  • Warburton S, Paulsson AK, Mitchell-Jordan SA, Ren S, Zhang M, Li Y, Ping P, Wang Y, Vondriska TM. “Quantitative Signatures of Cardiac Hypertrophy and Failure using Mass Spectrometry and Bioinformatics.”. Poster session presented at Mol Cell Proteomics, Toronto, Canada. Poster, Presented, 2009.
  • Warburton S, Paulsson AK, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM. “Proteomic Dissection of a Phenotypic Continuum between Myocardial Protection and Growth.”. Poster session presented at American Heart Association Young Investigator Forum, UC-Davis, Davis, CA. Poster, Presented, 2008.
  • Paulsson AK, Warburton S, Mitchell-Jordan SA, Ren S, Wang S, Wang Y, Vondriska TM. “Phenotypic Continuum between Growth and Protection: Analysis of Organellar Sub-proteomes in the Heart.". Poster session presented at Mol Cell Proteomics, Amsterdam, Netherlands. Poster, Presented, 2008.
  • Yusifov T, Gandhi C, Warburton S, Yusifova N, Vondriska TM, and Olcese R. “Proving Molecular Interactions between hSloRCK1 and hSloRCK2 Domains in BKCa Channels.”. Poster session presented at Biophysical Society Annual Meeting, Long Beach, California. Poster, Presented, 2008.
  • Yusifov T, Gandhi C, Warburton S, Malkhasyan V, Vondriska TM, lcese R. “Structural Analysis of the Calcium Sensors in BKCa Channels.”. Poster session presented at Biophysical Society Annual Meeting, Long Beach, California. Poster, Presented, 2008.
  • Zhang M, Warburton S, Mitchell SA, Wang S, Vondriska TM. “Investigation of Tec Tyrosine Kinase Expression and Signaling in Murine Myocardium.”. Poster session presented at Mol Cell Proteomics, Seoul, Korea. Poster, Presented, 2007.
  • Warburton S, Wang S, Zhang M, Mitchell SA, Vondriska TM. “Nitric Oxide Mediated Regulation of Bcl-2 Expression Dynamics in Heart.". Poster session presented at Mol Cell Proteomics, Seoul, Korea. Poster, Presented, 2007.
  • Warburton S, Wang S, Mitchell SA, Vondriska TM. "Proteomic Dissection of FAK Protein Complexes in Heart.” FASEB J, Washington, D.C. Poster, Presented, 2007.
  • Mitchell S, Wang S, Warburton S, Zhang M, Vondriska TM. “Bmx Non-receptor Tyrosine Kinase Mediation of Hypoxic Signaling in the Adult Myocardium.”. Poster session presented at FASEB J, Washington, D.C. Poster, Presented, 2007.
  • Zhang M, Warburton S, Mitchell SA, Wang S, Vondriska TM. “Characterization of the Tec Tyrosine Kinase Signaling Network in the Murine Myocardium.". Poster session presented at FASEB J, Washington, D.C. Poster, Presented, 2007.

Languages

  • English, Fluent.

Publications

  • Monte E, Mouillesseaux K, Chen H, Kimball T, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S (date unknown). Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. Vol. 305, H1624-38. Accepted, .
  • Ludlam WG, Aoba T, Cuéllar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM (date unknown). Molecular architecture of the Bardet-Biedl syndrome protein 2-7-9 subcomplex. Vol. 294, 16385-16399. Accepted, .
  • Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM (date unknown). The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Vol. 311, H1234-H1247. Accepted, .
  • Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S (date unknown). Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Vol. 29, 270-282.e5. Accepted, .
  • Szulik MW, Davis K, Bakhtina A, Azarcon P, Bia R, Horiuchi E, Franklin S (date unknown). Transcriptional regulation by methyltransferases and their role in the heart: highlighting novel emerging functionality. Vol. 319, H847-H865. Accepted, .
  • Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME (date unknown). GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Vol. 473, 3355-69. Accepted, .
  • Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S (date unknown). Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Vol. 115, E7871-E7880. Accepted, .
  • Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME (date unknown). GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Vol. 474, 2951. Accepted, .
  • Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y (date unknown). PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Vol. 2, 405-16. Accepted, .
  • Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM (date unknown). Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. Vol. 291, 15428-46. Accepted, .
  • Cuéllar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta JM (date unknown). Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Vol. 10, 2865. Accepted, .
  • Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS (date unknown). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Vol. 32, 1293-1312. Accepted, .
  • Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM (date unknown). Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Vol. 3. Accepted, .
  • Kumar P P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM (date unknown). TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. Vol. 10, e1004247. Accepted, .
  • Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV (date unknown). Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. Vol. 10, e0118974. Accepted, .
  • Plimpton RL, Cuéllar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL, Valpuesta JM, Willardson BM (date unknown). Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Vol. 112, 2413-8. Accepted, .
  • Tracy C, Warren JS, Szulik M, Wang L, Garcia J, Makaju A, Russell K, Miller M, Franklin S (date unknown). The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology. Vol. 1, 140-152. Accepted, .
  • Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN (date unknown). Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Vol. 4. Accepted, .
  • Franklin S, Zhang M, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM (date unknown). Specialized compartments of cardiac nuclei exhibit distinct proteome anatomy. Vol. 10. Accepted, .
  • Tracy C, Warren J, Szulik M, Wang L, Garcia J, Makaju A, Russel K, Miller M, Franklin S (date unknown). The Smyd family of methyltransferases: Role in cardiac and skeletal muscle physiology and pathology. (pp. 140-152). Vol. 1. Accepted, .