Research Statement
- Recombinant biopolymer/fusion protein platforms for facile modular assembly
- Microwave thermal ablation and thermo-targeted chemotherapy
- In vitro blood brain barrier models to advance pre-clinical development
- Hippocampal neurogenesis for Alzheimer's disease
Research Keywords
- siRNA Gene Therapy
- Zebrafish Nanotoxicity Models
- Osteosarcoma
- Nanotoxicology
- Microwave Thermal Ablation
- Interventional Oncology
- Gliomas
- Genetic Engineering
- Drug Delivery across the Blood Brain Barrier
- Drug Delivery Systems
- Blood-Brain Barrier
- Amyotrophic Lateral Sclerosis
- Alzheimer's Disease
Presentations
- Cleaning dirty tumor margins with thermo-targeted chemotherapy and microwave ablation. (2011) World Conference on Interventional Oncology; New York, New York. Invited Talk/Keynote, Presented, 06/09/2011.
- siRNA gene therapy across the blood brain barrier for neuro-disease. (2011) Merrimack Pharmaceuticals; Cambridge, MA. Invited Talk/Keynote, Presented, 04/25/2011.
- Targeted drug delivery across the blood brain barrier.(2011) Crocker Ventures; Salt Lake City, UT. Other, Presented, 03/22/2011.
- Cleaning tumor margins, thermal ablation, and gene therapy across the BBB – research review of the Furgeson Lab. (2011) University of Utah; Imaging, Diagnostics, and Therapeutics (IDT) program meeting; Salt Lake City, UT. Other, Presented, 03/10/2011.
- "Furgeson lab research overview: emphasizing interdisciplinary collaborations across campus" - Nanotechnology Training Program; University of Utah. Presentation, Presented, 08/16/2010.
- "Firing up capacitance-loaded microwave antennas for synergistic thermo-targeted drug delivery" - Dept. of Cardiology and CARMA Group; University of Utah. Presentation, Presented, 07/15/2010.
- "Using drug delivery's big promise to improve cancer therapy to small people" - Center for Children's Cancer Research (C3R) Supergroup; University of Utah. Presentation, Presented, 07/09/2010.
- "Translational research - targeted drug delivery and nanotoxicology" - Dept. of Pediatrics; School of Medicine; University of Utah. Presentation, Presented, 01/05/2010.
- O Bar-Ilan, RM Albrecht, VE Fako, and DY Furgeson. Nanotoxicity assessments of multi-sized silver and gold nanoparticles in zebrafish embryos. (2009) 48th Annual Meeting and Tox Expo; Society of Toxicology; Baltimore, MD, Mar 15-19. Conference Paper, Presented, 2009.
- ER Theisen and DY Furgeson. Nanotoxicity assessments with a whole zebrafish model. (2009) First International Conference on the Environmental Implications of Nanotechnology; Howard University, Washington, D.C., Sept 9-10. Conference Paper, Presented, 2009.
- Nanotherapy and Nanotoxicology: The Schizophrenia of Drug Delivery (2009) University of Utah; Dept. of Chemical Engineering Undergraduate Seminar; Salt Lake City, UT – Mar 10. Invited Talk/Keynote, Presented, 2009.
- Assessing biomaterial nanotoxicity with zebrafish embryos. (2009) University of Utah; Dept. of Bioengineering; Salt Lake City, UT – Mar 27. Invited Talk/Keynote, Presented, 2009.
- Microwave thermal ablation and thermosensitive chemotherapeutics. (2009) Huntsman Cancer Institute & Nano Institute of Utah Joint Symposium; Salt Lake City, UT – Apr 27. Invited Talk/Keynote, Presented, 2009.
- Thermal chemotherapeutics and microwave thermal ablation to eradicate tumor margins. (2009) University of Utah-Inha Drug Delivery and Therapeutics Global R&D Center; Incheon, Korea – Jun 22. Invited Talk/Keynote, Presented, 2009.
- Nanotoxicity assessments with a whole zebrafish model. (2009) First International Conference on the Environmental Implications of Nanotechnology; Washington, DC – Sept 9. Invited Talk/Keynote, Presented, 2009.
- Silver nanotoxicity – not just for werewolves anymore. (2009) University of Utah; Dept. of Medicinal Chemistry; Salt Lake City, UT – Oct 29. Invited Talk/Keynote, Presented, 2009.
- Zebrafish and nanotoxicology – accelerating pre-clinical development. (2009) University of Utah; Dept. of Pharmacology & Toxicology; Salt Lake City, UT – Nov 23. Invited Talk/Keynote, Presented, 2009.
Research Groups
- Yizhe Chen, Graduate Student. Pharmaceutics and Pharmaceutical Chemistry. 08/01/2009 - present.
- Pilju Youn, Graduate Student. Pharmaceutics and Pharmaceutical Chemistry. 08/01/2009 - present.
Grants, Contracts & Research Gifts
- Microwave Thermal Ablation. PI: Darin Y. Furgeson. Microsulis Medical, Ltd (U.K.), 06/01/2011 - present. Total project budget to date: $60,000.00
- Zebrafish Nanotoxicity Models for Pediatric Environmental Health. PI: Darin Y. Furgeson. Department of Pediatrics, 02/01/2010 - present. Total project budget to date: $35,000.00
- Microwave Thermal Ablation and Thermo-targeted Polymer-Geldanamycin Conjugates for Cancer. PI: Darin Y. Furgeson. Wallace H. Coulter Translational Partners Grant Program, 04/01/2008 - 03/31/2009. Total project budget to date: $70,000.00
- Rapid Pre-Clinical Development and Screening of Polymer-Geldanamycin Conjugates. PI: Darin Y. Furgeson. Nanotechnology Characterization Laboratory, 01/01/2007 - present. Total project budget to date: $0.00
Languages
- English, fluent.
Publications
- Y Chen, P Youn, and DY Furgeson. Thermo-targeted delivery of geldanamycin with diblock elastin-based biopolymers. J Control Rel (2011) 155(2):175-183. Published, 10/2011.
- VE Fako and DY Furgeson. Assessing biomaterial nanotoxicity with a novel zebrafish model. (2009) Adv Drug Del Rev (2009) 61(6):478-486.
Published, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19389433 - DY Furgeson, RN Cohen, RI Mahato, and SW Kim. Novel water insoluble lipoparticulates for gene delivery. Pharm Res (2002) 19(4):382-390. (IF 4.456). Published, 06/2002.
- J Benns, A Maheshwari, DY Furgeson, RI Mahato, and SW Kim. Folate-PEG-Folate-graft-Polyethylenimine-based cytokine gene delivery for cancer treatment. J Drug Target (2001) 9(2):123-139. (IF 3.024). Accepted, 06/2001.