DONALD K BLUMENTHAL, II portrait
  • Associate Dean for Interprofessional Education and Assessment, College Of Pharmacy
  • Adjunct Associate Professor, Department Of Biochemistry
  • Adjunct Associate Professor, Biomedical Informatics Resrch
  • Associate Professor, Pharmacology And Toxicology
  • Adjunct Associate Professor, Biochemistry Research
801-585-3094

Research Keywords

  • Use of synthetic peptides as probes of protein structure, function, and regulation
  • Role of protein kinases in disease processes and as potential drug targets
  • Molecular aspects of protein kinase and calmodulin-target enzyme interactions
  • Development of novel reagents and techniques for studying protein kinases and phosphatases

Presentations

  • 3D Virtual Cell Conference, UCSD, "Drug Action and Cell Signalling in a 3D Virtual Cell". Invited Talk/Keynote, Presented, 12/15/2012.
    http://www.3dvcell.org/conference-toward-3d-virtua...
  • Symposium – Neutrons in Structural Biology, Oak Ridge National Laboratory: "Protein Kinase A: A model for multi-subunit/multi-protein intracellular signaling systems". Invited Talk/Keynote, Presented, 06/04/2012.
    http://neutrons.ornl.gov/conf/gcnb2012/
  • "Multidimensional Opportunities for Scattering Studies" presented at PKA Workshop: Opportunities for Neutron Diffraction and Small Angle Xray and Neutron Scattering; Organizers: Paul Langan, Susan Taylor, Don Blumenthal December 13/14, 2011 University of California, San Diego . Invited Talk/Keynote, Presented, 12/12/2011.
  • "Interprofessional Education (IPE) in Introductory Pharmacy Practice Experiences (IPPEs): Current status and implementation practices in US colleges of pharmacy" presented at a special session of the Annual Meeting of the American Association of Colleges of Pharmacy, San Antonio, TX. Conference Paper, Presented, 07/12/2011.

Research Groups

  • Sean Cornillie, Graduate Student. Biological Chemistry Graduate Program. 08/2011 - 10/2011.

Languages

  • English, fluent.

Geographical Regions of Interest

  • Argentina
    Collaborator with Silvia Moreno, Professor of Biochemistry and Molecular Biology, University of Buenos Aires, Argentina.
  • India
  • Latin America and the Caribbean
  • Northern Europe
  • Western Europe

Publications

  • "Novel Localization and Quaternary Structure of the PKA RIβ Holoenzyme." R. Ilouz, J. Bubis, J. Wu, Y. Y. Yim, M.S. Deal, A.P. Kornev, Y. Ma, D.K. Blumenthal, S.S. Taylor (2012) Proc. Natl. Acad. Sci. USA 109, 12443-8. Published, 07/2012.
  • "Survey of Interprofessional Education in IPPEs at US Colleges of Pharmacy." K.M. Jones, D.K. Blumenthal, J.M. Burke, M. Condren, R. Hansen, M. Holiday-Goodman, C.D. Peterson (2012) Am. J. Pharm. Educ. 76:Article 80 (9 pages). Published, 06/2012.
  • "In Vivo Evaluation of the Delivery and Efficacy of a Sirolimus-Laden Polymer Gel for Inhibition of Hyperplasia in a Porcine Model of Arteriovenous Hemodialysis Graft Stenosis." C.M. Terry, L. Li, H. Li, I. Zhuplatov, D.K. Blumenthal, S.-E. Kim, S.C. Owen, E. Kholmovski, K.D. Fowers, R. Rathi, A.K. Cheung (2012) J. Control. Release 160:459-67. Published, 03/2012.
  • "Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme". Structure. 2011 Feb 9;19(2):265-76. Published, 02/2011.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309748...
  • "PDGF-induced proliferation in human arterial and venous smooth muscle cells: molecular basis for differential effects of PDGF isoforms". J Cell Biochem. 2011 Jan;112(1):289-98. Published, 01/2011.
    http://www.ncbi.nlm.nih.gov/pubmed/21069732
  • "Pharmacodynamics: Molecular Mechanisms of Drug Action" Donald K. Blumenthal and James C. Garrison (in press), Chapter 3 of the 12th edition of Goodman & Gilman's The Pharmacological Basis of Therapeutics. Published, 12/2010.
  • "Proteins at Work: A Combined SAXS and Theoretical Determination of the Multiple Structures Involved on the Protein Kinase Functional Landscape" M.A. Jamros, L.C. Oliveira, P.C. Whitford, J.N. Onuchic, J.A. Adams, D.K. Blumenthal, P.A. Jennings J. Biol. Chem. 285, 36121-8. Published, 08/2010.
    http://www.jbc.org/content/285/46/36121.long
  • "Sensing Domain Dynamics in PKA-RIα Complexes by Solution X-ray Scattering" C.Y. Cheng, J. Yang, S.S. Taylor & D.K. Blumenthal (2009) J. Biol. Chem. 284, 35916– 35925. Published, 2009.
  • "Mechanism of Epac Activation: Structural and Functional Analyses of Epac2 Hinge Mutants with Constitutive and Reduced Activities" T. Tsalkova, D.K. Blumenthal, F.C. Mei, M. A. White & X. Cheng, (2009) J. Biol. Chem. 284, 23644-23651. Published, 2009.
  • "Longitudinal Assessment of Hyperplasia using Magnetic Resonance Imaging without Contrast in a Porcine Arteriovenous Graft Model" C.M. Terry, S.-E. Kim, L. Li, K.C. Goodrich, J.R. Hadley, D.K. Blumenthal, D.L. Parker & A.K. Cheung (2009) Academic Radiology 16, 96-107. Published, 2009.
  • Goodman & Gilman Online Animation: Dopaminergic Neuroeffector Junction. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Adrenergic Neuroeffector Junction. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Cholinergic Neuroeffector Junction. Published, 2008.
    http://www.accessmedicine.com
  • "Goodman & Gilman Online" L.L. Brunton, I.L.O. Buxton, K.L. Parker and D.K. Blumenthal (eds.). Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: AV Node Electrophysiology. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Atrial Myocyte Electrophysiology. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Sinus Node Electrophysiology. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: GABAergic Synaptic Transmission. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Effects of Drugs on the Electrocardiogram. Published, 2008.
    http://www.accessmedicine.com
  • Goodman & Gilman Online Animation: Ventricular Myocyte Electrophysiology. Published, 2008.
    http://www.accessmedicine.com
  • "Goodman & Gilman's Manual of Pharmacology and Therapeutics" L.L. Brunton, K.L. Parker, D.K. Blumenthal, I.L.O. Buxton (eds.). McGraw-Hill, publisher. Published, 2008.