ROBIN L. MARCUS, PhD portrait
  • Chief Wellness Officer, Office Of Sr Vp Health Sci
  • Adjunct Associate Professor, Kinesiology
  • Adjunct Associate Professor, Occupational & Recreational Therapies
  • Professor, Physical Therapy & Athletic Training

Research Statement

I am particularly interested in the plasticity of skeletal muscle and how it responds to mechanical stress or Resistance Exercise via Negative Eccentric Work (RENEW).  We have observed that in addition to improving mobility and metabolic function in older adults, RENEW also results in changes in muscle composition - both increasing lean tissue and decreasing intramuscular adipose tissue.  Specifically, I am interested in the role of abnormal adipose tissue deposition and its consequences on mobility and metabolic impairment.  This important research direction may provide novel therapeutic targets for combating physical disability in older adults with a variety of co-morbid disease conditions including diabetes, sarcopenia and arthritis.

Research Keywords

  • Total Knee Arthroplasty
  • Muscle
  • Mobility
  • Intramuscular adipose tissue
  • Exercise
  • Elderly
  • Eccentric Resistance Training
  • Community Exercise Programs

Presentations

  • Eccentric Exercise Training in Sport and Rehabilitation: Eccentric Exercise as a Novel Rehabilitation Modality, 2011 European College of Sport Science Congress. Invited Talk/Keynote, Presented, 07/2011.
  • 8th Annual Rocky Mountain Geriatrics Conference: Impaired Muscle and Mobility, the Road from Functional to Frail, Park City, UT. Invited Talk/Keynote, Presented, 07/2010.
  • Exploiting Exercise and Motor Control Physiology To Optimize Outcomes, American Physical Therapy Association, Utah Chapter Annual Conference, Layton, UT. Invited Talk/Keynote, Presented, 07/2009.
  • 7th Annual Rocky Mountain Geriatrics Conference: Updates in Geriatrics: Crossing Disciplines and Distance. Aging and Fat: The Obvious and Not so Obvious Depots and Impact. Invited Talk/Keynote, Presented, 07/2009.

Research Groups

  • Robin Marcus, Other. Skeletal Muscle Exercise Research Facility. 01/01/2006 - present.

Research Equipment and Testing Expertise

  • Kin-Com Isokinetic Dynamometer, Nottingham Power Rig, Mobility and Physical Performance Testing.

Languages

  • English, fluent.

Publications

  • Foreman KB, Singer ML, Addison O, Marcus RL, Lastayo PC, Dibble LE. Effects of dopamine replacement therapy on lower extremity kinetics and kinematics during a rapid force production task in persons with Parkinson disease. Gait Posture. 2013. doi:10.1016/j.gaitpost.2013.07.114. Published, 08/2013.
  • Lastayo P, Marcus RL, Dibble L, Frajacomo F, Lindstedt SL. Eccentric exercise in rehabilitation: safety, feasibility, and application. J Appl Physiol. 2013. doi:10.1152/japplphysiol.00008.2013. Published, 07/2013.
  • Goodman MJ, Ghate SR, Mavros P, et al. Development of a practical screening tool to predict low muscle mass using NHANES 1999-2004. J Cachexia Sarcopenia Muscle. 2013. doi:10.1007/sl3539-013-0107-9. Published, 05/2013.
  • Painter P, Marcus RL. Assessing physical function and physical activity in patients with CKD. Clin J Am Soc Nephrol. 2013;8(5):861-872. doi:10.2215/CJN/06590712. Published, 12/06/2012.
  • Gibson BS, Colberg SR, Poirier P, Vancea DMM, Jones J, Marcus R. Development and validation of a predictive model of acute glucose reponse to exercise in individuals with type 2 diabetes. Diabetol Metab Syndr. 2013;5(1):33. doi:10.1186/1758-5996-5-33. Published, 12/2012.
  • Yoshida Y, Marcus RL, Lastayo PC. Intramuscular adipose tissue and central activation in older adults. Muscle Nerve. 2012;46(5):813-816. doi:10.1002/mus.23506. Published, 11/2012.
  • Smith AG, Marcus RL. Exercise for diabetic neuropathy: a toe in the therapeutic door. J Diabetes Complicat. 2012;26(5):361-362. doi:10.1016/jdiacomp.2012.06.005. Published, 10/2012.
  • Addison O, LaStayo PC, Dibble LE, Marcus RL. Inflammation, aging, and adiposity: implications for physical therapists. J Geriatr Phys Ther. 2012;35(2):86-94. doi:10.1519/JPT.0b013e3182312b14. Published, 04/2012.
  • Gibson B, Marcus RL, Staggers N. Jones J. Samore M, Weir C. Efficacy of a computerized simulation in promoting walking in individuals with diabetes. J Med Internet Res. 2012;14(3):371. doi:10.2196/jmir.1965. Published, 10/2012.
  • Marcus RL, Brixner DI, Ghate S, Lastayo P. Fat modulates the relationship between sarcopenia and physical function in nonobese older adults. Curr Gerontol Geriatr Res. 2012;2012:216185. doi:10.1155.2012/216185. Published, 01/2012.
  • Drummond MJ, Marcus RL, Lastayo PC. Targeting anabolic impairment in response to resistance exercise in older adults with mobility impairments: potential mechanisms and rehabilitation approaches. J Aging Res. 2012;2012:486930. doi:10.1155/2012/486930. Published, 01/2012.
  • Marcus RL, Addison O, Dibble LE, Foreman KB, Morrell G, Lastoya P. Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals. J Aging Res. 2012;2012:629637. doi:10.1155/2012/629637. Published, 02/2012.
  • Lastayo PC, Marcus RL, Dibble LE, Smith SB, Beck SL. Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility--an exploratory pilot study. BMC Geriatr. 2011;11:5. doi:10.1186/1471-2318-11-5. Published, 01/2011.
  • Marcus RL, Yoshida Y, Meier W, Peters CL, Lastayo PC. An eccentrically-biased rehabilitation program early after TKA surgery. Arthritis 2011;2011:353149. doi:10.1155/2011/353149. Published, 07/2011.
  • Lastayo PC, Larsen S, Smith S, Dibble L, Marcus RL. The feasibility and efficacy of eccentric exercise with older cancer survivors: a preliminary study. J Geriatr Phys Ther. 2010:33(3):135-140. Published, 01/2010.
  • Hebert JJ, Marcus RL, Koppenhaver SL, Fritz JM. Postoperative rehabilitation following lumbar discectomy with quantification of trunk muscle morphology and function: a case report and review of the literature. J Orthop Sports Phys Ther. 2010;40(7):402-412. doi:10.2519/jospt.2010.3332. Published, 01/2011.
  • Dibble LE, Hale TF, Marcus RL, Gerber JP, Lastayo PC. High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson disease: a preliminary study. Parkinsonism Relat Disord. 2009;15(10:752-757. doi:10/1016/j.parkreldis.2009.04.009. Published, 06/2009.
  • Lastayo PC, Meier W, Marcus RL, Mizner R, Dibble L, Peters C. Reversing muscle and mobility deficits 1 to 4 years after TKA: a pilot study. Clin Orthop Relat Res. 2009;467(6):1493-1500. doi:10.1007/sl1999-009-0801-2. Published, 03/2009.
  • Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt). 2009;18(2):253-260. doi:10.1089/jwh.2007.0669.. Published, 02/2009.
  • Gerber JP, Marcus RL, Dibble LE, Greis PE, Burks RT, Lastayo PC. Effects of early progressive eccentric exercise on muscle size and function after anterior cruciate ligament reconstruction: a 1-year follow-up study of a randomized clinical trial. Phys Ther. 2009;89(1):51-59. doi:10.2522/ptj.20070189. Published, 11/2008.
  • Gerber JP, Marcus RL, Dibble LE, Greis P, Burks RT, Lastayo PC. The use of eccentrically-biased resistance exercise to mitigate muscle impairments following anterior cruciate ligament reconstruction: a short review. Sports Health. 2009;1(1):3313-38. doi:10.1177/1941738108327531. Published, 01/2009.
  • Kidde J, Marcus R, Dibble L, Smith S, Lastayo P. Regional muscle and whole-body composition factors related to mobility in older individuals: a review. Physiother Can. 2009;61(4):197-209. doi:10.3138/physio.61.4.197. Published, 11/2009.
  • Meier WA, Marcus RL, Dibble LE, et al. The long-term contribution of muscle activation and muscle size to quadriceps weakness following total knee arthroplasty. J Geriatr Phys Ther. 2009;32(2):79-82. Published, 01/2009.
  • Marcus RL, Smith S, Morrell G, et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther. 2008;88(11):1345-1354. doi:10.2522/ptj.20080124. Published, 11/2008.
  • Kirkness CS, Marcus RL, Lastayo PC, Asche CV, Fritz JM. Diabetes and associated risk factors in patients referred for physical therapy in a national primary care electronic medical record database. Phys Ther. 2008;88(11):1408-1416. doi:10.2522/ptj.20080129. Published, 10/2008.
  • Meier W, Mizner RL, Marcus RL, Dibble LE, Peters C, Lastayo PC. Total knee arthroplasty: muscle impairments, functional limitations, and recommended rehabilitation approaches. J Orthop Sports Phys Ther. 2008;38(5):246-256. doi:10.2519/jospt.2008.2715. Published, 12/2008.
  • Marcus RL, Graybill CS, Lastayo PC. Impaired muscle and mobility: the road from menopause to frailty. Clin Obstet Gynecol. 2007;50(3):776-789. doi:10.1097/GRF.0b013e3180dbc37d. Published, 09/2007.
  • Gerber JP, Marcus RL, Dibble LE, Greis PE, Burks RT, Lastayo PC. Effects of early progressive eccentric exercise on muscle structure after anterior cruciate ligament reconstruction. J Bone Joint Surg Am. 2007;89(3):559-570. doi:10.2106/JBJS.F.00385. Published, 03/2007.
  • Gerber JP, Marcus RL, Dibble LE, Greis PE, Burks RT, Lastayo PC. Safety, feasibility, and efficacy of negative work exercise via eccentric muscle activity following anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther. 2007;37(1):10-18. doi:10.2519/jospt.2007.2362. Published, 01/2007.
  • Dibble LE, Hale T, Marcus RL, Gerber JP, Lastayo PC. The safety and feasibility of high-force eccentric resistance exercise in persons with Parkinson's disease. Arch Phys Med Rehabil. 2006;87(9):1280-1282. doi:10.1016/j.apmr.2006.05.016. Published, 09/2006.