Realizing the powerful impact of physical activity and exercise interventions on a variety of health related outcomes in older adults, my research interests revolve around both the mechanisms of how exercise improves health outcomes, and importantly how to bring the benefits of exercise to more older adults in our the communities.
I am particularly interested in the plasticity of skeletal muscle and how it responds to mechanical stress or Resistance Exercise via Negative Eccentric Work (RENEW). We have observed that in addition to improving mobility and metabolic function in older adults, RENEW also results in changes in muscle composition - both increasing lean tissue and decreasing intramuscular adipose tissue. Specifically, I am interested in the role of abnormal adipose tissue deposition and its consequences on mobility and metabolic impairment. This important research direction may provide novel therapeutic targets for combating physical disability in older adults with a variety of co-morbid disease conditions including diabetes, sarcopenia and arthritis.