BALDOMERO M OLIVERA portrait
  • Distinguished Professor, School Of Biological Sciences
  • HCI Experimental Therapeutics Group Member , Huntsman Cancer Institute

Publications

  • Olivera BM (2021). A Serendipitous Path to Pharmacology. Annual review of pharmacology and toxicology. Vol. 61, 9-23. Published, 01/01/2021.
  • Lu A, Watkins M, Li Q, Robinson SD, Concepcion GP, Yandell M, Weng Z, Olivera BM, Safavi-Hemami H & Fedosov AE (2021). Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus. Genome biology and evolution. Vol. 12, 684-700. Published, 01/01/2021.
  • Raghuraman S, Xie JY, Giacobassi MJ, Tun JO, Chase K, Lu D, Teichert RW, Porreca F & Olivera BM (2021). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences of the United States of America. Vol. 117, 26414-26421. Published, 01/01/2021.
  • Kilburn RN, Fedosov AE & Olivera BM (2020). Revision of the genus Turris (Gastropoda: Conoidea: Turridae) with the description of six new species. Zootaxa. Vol. 3244, 1-58. Published, 10/01/2020.
  • Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM & Schmidt EW (2020). Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. Journal of natural products. Vol. 83, 1249-1257. Published, 10/01/2020.
  • van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM & McIntosh JM (2020). α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors. Neuropharmacology. Vol. 157, 107691. Published, 07/01/2020.
  • Giacobassi MJ, Leavitt LS, Raghuraman S, Alluri R, Chase K, Finol-Urdaneta RK, Terlau H, Teichert RW & Olivera BM (2020). An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses. Proceedings of the National Academy of Sciences of the United States of America. Vol. 117, 5494-5501. Published, 07/01/2020.
  • Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K & Ellgaard L (2020). The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework. The Journal of biological chemistry. Vol. 294, 8745-8759. Published, 02/01/2020.
  • Safavi-Hemami H, Brogan SE & Olivera BM (2020). Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways. Journal of proteomics. Vol. 190, 12-20. Published, 02/01/2020.
  • Puillandre N, Duda TF, Meyer C, Olivera BM & Bouchet P (2019). One, four or 100 genera? A new classification of the cone snails. The Journal of molluscan studies. Vol. 81, 1-23. Published, 11/01/2019.
  • Puillandre N, Meyer CP, Bouchet P & Olivera BM (2019). Genetic divergence and geographic variation in the deep-water Conus orbignyi complex (Mollusca: Conoidea). Zoologica scripta. Vol. 40, 350-363. Published, 11/01/2019.
  • Memon T, Yarishkin O, Reilly CA, Križaj D, Olivera BM & Teichert RW (2019). trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel. Molecular pharmacology. Vol. 95, 433-441. Published, 06/01/2019.
  • Cordeiro S, Finol-Urdaneta RK, Köpfer D, Markushina A, Song J, French RJ, Kopec W, de Groot BL, Giacobassi MJ, Leavitt LS, Raghuraman S, Teichert RW, Olivera BM & Terlau H (2019). Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels. Proceedings of the National Academy of Sciences of the United States of America. Vol. 116, 1059-1064. Published, 03/01/2019.
  • Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM & Liu Q (2018). Conopeptides promote itch through human itch receptor hMgprX1. Toxicon : official journal of the International Society on Toxinology. Vol. 154, 28-34. Published, 12/01/2018.
  • Olivera BM, Raghuraman S, Schmidt EW & Safavi-Hemami H (2018). Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. Vol. 203, 717-735. Published, 06/01/2018.
  • Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM & McIntosh JM (2018). Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. Vol. 114, E1825-E1832. Published, 04/01/2018.
  • Memon T, Chase K, Leavitt LS, Olivera BM & Teichert RW (2018). TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons. Neuroscience. Vol. 353, 76-86. Published, 03/01/2018.
  • Li Q, Barghi N, Lu A, Fedosov AE, Bandyopadhyay PK, Lluisma AO, Concepcion GP, Yandell M, Olivera BM & Safavi-Hemami H (2018). Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. Genome biology and evolution. Vol. 9, 2211-2225. Published, 02/01/2018.
  • Green BR & Olivera BM (2018). Venom Peptides From Cone Snails: Pharmacological Probes for Voltage-Gated Sodium Channels. Current topics in membranes. Vol. 78, 65-86. Published, 01/01/2018.
  • Barghi N, Concepcion GP, Olivera BM & Lluisma AO (2018). Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis. Vol. 27, 4451-4452. Published, 01/01/2018.
  • Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM & Concepcion GP (2017). Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom. Biochemistry. Vol. 56, 6051-6060. Published, 11/01/2017.
  • Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera BM, Light A & Schmidt EW (2017). Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products. Journal of natural products. Vol. 80, 2360-2370. Published, 10/01/2017.
  • Drane SB, Robinson SD, MacRaild CA, Chhabra S, Chittoor B, Morales RA, Leung EW, Belgi A, Espino SS, Olivera BM, Robinson AJ, Chalmers DK & Norton RS (2017). Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon : official journal of the International Society on Toxinology. Vol. 129, 113-122. Published, 08/01/2017.
  • Safavi-Hemami H, Lu A, Li Q, Fedosov AE, Biggs J, Showers Corneli P, Seger J, Yandell M & Olivera BM (2017). Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa. Molecular biology and evolution. Vol. 33, 2924-2934. Published, 06/01/2017.
  • Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H & Lawrence MC (2017). A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nature structural & molecular biology. Vol. 23, 916-920. Published, 05/01/2017.
  • Espino SS, Dilanyan T, Imperial JS, Aguilar MB, Teichert RW, Bandyopadhyay P & Olivera BM (2016). Glycine-rich conotoxins from the Virgiconus clade. Toxicon : official journal of the International Society on Toxinology. Vol. 113, 11-7. Published, 12/01/2016.
  • Curtice KJ, Leavitt LS, Chase K, Raghuraman S, Horvath MP, Olivera BM & Teichert RW (2016). Classifying neuronal subclasses of the cerebellum through constellation pharmacology. Journal of neurophysiology. Vol. 115, 1031-42. Published, 10/01/2016.
  • Safavi-Hemami H, Li Q, Jackson RL, Song AS, Boomsma W, Bandyopadhyay PK, Gruber CW, Purcell AW, Yandell M, Olivera BM & Ellgaard L (2016). Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides. Proceedings of the National Academy of Sciences of the United States of America. Vol. 113, 3227-32. Published, 09/01/2016.
  • Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D & Norton RS (2016). Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. The Journal of biological chemistry. Vol. 291, 7205-20. Published, 08/01/2016.
  • Olivera BM, Seger J, Horvath MP & Fedosov AE (2016). Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution. Brain, behavior and evolution. Vol. 86, 58-74. Published, 07/01/2016.
  • Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE & Schmidt EW (2016). Metabolic model for diversity-generating biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. Vol. 113, 1772-7. Published, 07/01/2016.
  • Barghi N, Concepcion GP, Olivera BM & Lluisma AO (2016). Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Molecular genetics and genomics : MGG. Vol. 291, 411-22. Published, 05/01/2016.
  • Neves JL, Lin Z, Imperial JS, Antunes A, Vasconcelos V, Olivera BM & Schmidt EW (2016). Small Molecules in the Cone Snail Arsenal. Organic letters. Vol. 17, 4933-5. Published, 02/01/2016.
  • Wilson MJ, Zhang MM, Gajewiak J, Azam L, Rivier JE, Olivera BM & Yoshikami D (2015). Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ. Journal of neurophysiology. Vol. 113, 2289-301. Published, 12/01/2015.
  • Christensen SB, Bandyopadhyay PK, Olivera BM & McIntosh JM (2015). αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors. Biochemical pharmacology. Vol. 96, 349-56. Published, 11/01/2015.
  • Robinson SD, Safavi-Hemami H, Raghuraman S, Imperial JS, Papenfuss AT, Teichert RW, Purcell AW, Olivera BM & Norton RS (2015). Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. Journal of proteomics. Vol. 114, 38-47. Published, 10/01/2015.
  • Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM & Yoshikami D (2015). Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry. Vol. 54, 3911-20. Published, 09/01/2015.
  • Barghi N, Concepcion GP, Olivera BM & Lluisma AO (2015). High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. Marine biotechnology (New York, N.Y.). Vol. 17, 81-98. Published, 09/01/2015.
  • Teichert RW, Schmidt EW & Olivera BM (2015). Constellation pharmacology: a new paradigm for drug discovery. Annual review of pharmacology and toxicology. Vol. 55, 573-89. Published, 09/01/2015.
  • Aman JW, Imperial JS, Ueberheide B, Zhang MM, Aguilar M, Taylor D, Watkins M, Yoshikami D, Showers-Corneli P, Safavi-Hemami H, Biggs J, Teichert RW & Olivera BM (2015). Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proceedings of the National Academy of Sciences of the United States of America. Vol. 112, 5087-92. Published, 06/01/2015.
  • Olivera BM, Showers Corneli P, Watkins M & Fedosov A (2015). Biodiversity of cone snails and other venomous marine gastropods: evolutionary success through neuropharmacology. Annual review of animal biosciences. Vol. 2, 487-513. Published, 06/01/2015.
  • Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L & Olivera BM (2015). Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proceedings of the National Academy of Sciences of the United States of America. Vol. 112, 1743-8. Published, 05/01/2015.
  • Imperial JS, Cabang AB, Song J, Raghuraman S, Gajewiak J, Watkins M, Showers-Corneli P, Fedosov A, Concepcion GP, Terlau H, Teichert RW & Olivera BM (2015). A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity. Toxicon : official journal of the International Society on Toxinology. Vol. 89, 45-54. Published, 04/01/2015.
  • Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM & Bosmans F (2015). From foe to friend: using animal toxins to investigate ion channel function. Journal of molecular biology. Vol. 427, 158-175. Published, 03/01/2015.
  • Puillandre N, Bouchet P, Duda TF, Kauferstein S, Kohn AJ, Olivera BM, Watkins M & Meyer C (2015). Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea). Molecular phylogenetics and evolution. Vol. 78, 290-303. Published, 01/01/2015.
  • Platt RJ, Curtice KJ, Twede VD, Watkins M, Gruszczyński P, Bulaj G, Horvath MP & Olivera BM (2014). From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon : official journal of the International Society on Toxinology. Vol. 81, 67-79. Published, 12/01/2014.
  • Safavi-Hemami H, Hu H, Gorasia DG, Bandyopadhyay PK, Veith PD, Young ND, Reynolds EC, Yandell M, Olivera BM & Purcell AW (2014). Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization. Molecular & cellular proteomics : MCP. Vol. 13, 938-53. Published, 11/01/2014.
  • Green BR, Zhang MM, Chhabra S, Robinson SD, Wilson MJ, Redding A, Olivera BM, Yoshikami D, Bulaj G & Norton RS (2014). Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. The FEBS journal. Vol. 281, 2885-98. Published, 09/01/2014.
  • Lin Z, Zachariah MM, Marett L, Hughen RW, Teichert RW, Concepcion GP, Haygood MG, Olivera BM, Light AR & Schmidt EW (2014). Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. Journal of natural products. Vol. 77, 1224-30. Published, 09/01/2014.
  • Zhang MM, Wilson MJ, Gajewiak J, Rivier JE, Bulaj G, Olivera BM & Yoshikami D (2014). Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins. (pp. 102-14). Vol. 169. British journal of pharmacology. Published, 09/01/2014.
  • Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G & Norton RS (2014). Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS chemical biology. Vol. 8, 1344-51. Published, 08/01/2014.
  • Gilchrist J, Olivera BM & Bosmans F (2014). Animal toxins influence voltage-gated sodium channel function. Handbook of experimental pharmacology. Vol. 221, 203-29. Published, 07/01/2014.
  • Raghuraman S, Garcia AJ, Anderson TM, Twede VD, Curtice KJ, Chase K, Ramirez JM, Olivera BM & Teichert RW (2014). Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling. Proceedings of the National Academy of Sciences of the United States of America. Vol. 111, 6449-54. Published, 06/01/2014.
  • Teichert RW, Memon T, Aman JW & Olivera BM (2014). Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass. Proceedings of the National Academy of Sciences of the United States of America. Vol. 111, 2319-24. Published, 05/01/2014.
  • Ul-Hasan S, Burgess DM, Gajewiak J, Li Q, Hu H, Yandell M, Olivera BM & Bandyopadhyay PK (2014). Characterization of the peptidylglycine α-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus. Toxicon : official journal of the International Society on Toxinology. Vol. 74, 215-24. Published, 05/01/2014.
  • Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, Wickenden AD, Olivera BM, Yoshikami D & Zhang MM (2014). A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proceedings of the National Academy of Sciences of the United States of America. Vol. 111, 2758-63. Published, 04/01/2014.
  • Lin Z, Marett L, Hughen RW, Flores M, Forteza I, Ammon MA, Concepcion GP, Espino S, Olivera BM, Rosenberg G, Haygood MG, Light AR & Schmidt EW (2014). Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorganic & medicinal chemistry letters. Vol. 23, 4867-9. Published, 04/01/2014.
  • Lin Z, Koch M, Pond CD, Mabeza G, Seronay RA, Concepcion GP, Barrows LR, Olivera BM & Schmidt EW (2014). Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. The Journal of antibiotics. Vol. 67, 121-6. Published, 03/01/2014.
  • Aguilar MB, Zugasti-Cruz A, Falcón A, Batista CV, Olivera BM & de la Cotera EP (2013). A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides. Vol. 41, 38-44. Published, 12/01/2013.
  • Zhang MM, Wilson MJ, Azam L, Gajewiak J, Rivier JE, Bulaj G, Olivera BM & Yoshikami D (2013). Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. British journal of pharmacology. Vol. 168, 1597-610. Published, 11/01/2013.
  • Fedosov AÉ, Moshkovskiĭ SA, Kuznetsova KG & Olivera BM (2013). [Conotoxins: from the biodiversity of gastropods to new drugs]. (pp. 267-94). Vol. 59. Biomeditsinskaia khimiia. Published, 09/01/2013.
  • Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM & Schmidt EW (2013). A bacterial source for mollusk pyrone polyketides. Chemistry & biology. Vol. 20, 73-81. Published, 07/01/2013.
  • Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G & Norton RS (2013). Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry. Vol. 51, 9826-35. Published, 03/01/2013.
  • Puillandre N, Koua D, Favreau P, Olivera BM & Stöcklin R (2013). Molecular phylogeny, classification and evolution of conopeptides. Journal of molecular evolution. Vol. 74, 297-309. Published, 03/01/2013.
  • Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM & van der Donk WA (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural product reports. Vol. 30, 108-60. Published, 02/01/2013.
  • Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G & Purcell AW (2012). Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. The Journal of biological chemistry. Vol. 287, 34288-303. Published, 12/01/2012.
  • Olivera BM, Watkins M, Bandyopadhyay P, Imperial JS, de la Cotera EP, Aguilar MB, Vera EL, Concepcion GP & Lluisma A (2012). Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Annals of the New York Academy of Sciences. Vol. 1267, 61-70. Published, 11/01/2012.
  • Kraus NJ, Watkins M, Bandyopadhyay PK, Seger J, Olivera BM & Corneli PS (2012). A very short, functionally constrained sequence diagnoses cone snails in several Conasprella clades. Molecular phylogenetics and evolution. Vol. 65, 335-8. Published, 11/01/2012.
  • Olivera BM (2012). QnAs with Baldomero M. Olivera. Interview by Beth Azar. (pp. 13470). Vol. 109. Proceedings of the National Academy of Sciences of the United States of America. Published, 10/01/2012.
  • Teichert RW, Raghuraman S, Memon T, Cox JL, Foulkes T, Rivier JE & Olivera BM (2012). Characterization of two neuronal subclasses through constellation pharmacology. Proceedings of the National Academy of Sciences of the United States of America. Vol. 109, 12758-63. Published, 10/01/2012.
  • Steiner AM, Woycechowsky KJ, Olivera BM & Bulaj G (2012). Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angewandte Chemie (International ed. in English). Vol. 51, 5580-4. Published, 10/01/2012.
  • Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM & Bulaj G (2012). Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. Vol. 51, 4685-92. Published, 09/01/2012.
  • Gowd KH, Blais KD, Elmslie KS, Steiner AM, Olivera BM & Bulaj G (2012). Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs. Biopolymers. Vol. 98, 212-23. Published, 08/01/2012.
  • Lin Z, Flores M, Forteza I, Henriksen NM, Concepcion GP, Rosenberg G, Haygood MG, Olivera BM, Light AR, Cheatham TE & Schmidt EW (2012). Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp. Journal of natural products. Vol. 75, 644-9. Published, 07/01/2012.
  • Lluisma AO, Milash BA, Moore B, Olivera BM & Bandyopadhyay PK (2012). Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Marine genomics. Vol. 5, 43-51. Published, 05/01/2012.
  • Teichert RW, Smith NJ, Raghuraman S, Yoshikami D, Light AR & Olivera BM (2012). Functional profiling of neurons through cellular neuropharmacology. Proceedings of the National Academy of Sciences of the United States of America. Vol. 109, 1388-95. Published, 03/01/2012.
  • Cabang AB, Imperial JS, Gajewiak J, Watkins M, Corneli PS, Olivera BM & Concepcion GP (2012). Characterization of a venom peptide from a crassispirid gastropod. Toxicon : official journal of the International Society on Toxinology. Vol. 58, 672-80. Published, 03/01/2012.
  • Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G & Zhang MM (2011). μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proceedings of the National Academy of Sciences of the United States of America. Vol. 108, 10302-7. Published, 09/01/2011.
  • Wilson MJ, Zhang MM, Azam L, Olivera BM, Bulaj G & Yoshikami D (2011). Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. (pp. 687-93). Vol. 338. The Journal of pharmacology and experimental therapeutics. Published, 09/01/2011.
  • Lin Z, Reilly CA, Antemano R, Hughen RW, Marett L, Concepcion GP, Haygood MG, Olivera BM, Light A & Schmidt EW (2011). Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. Journal of medicinal chemistry. Vol. 54, 3746-55. Published, 08/01/2011.
  • Fedosov A, Watkins M, Heralde FM, Corneli PS, Concepcion GP & Olivera BM (2011). Phylogeny of the genus Turris: correlating molecular data with radular anatomy and shell morphology. Molecular phylogenetics and evolution. Vol. 59, 263-70. Published, 08/01/2011.
  • Kraus NJ, Corneli PS, Watkins M, Bandyopadhyay PK, Seger J & Olivera BM (2011). Against expectation: a short sequence with high signal elucidates cone snail phylogeny. Molecular phylogenetics and evolution. Vol. 58, 383-9. Published, 05/01/2011.
  • Anderson WA, Banerjee U, Drennan CL, Elgin SC, Epstein IR, Handelsman J, Hatfull GF, Losick R, O'Dowd DK, Olivera BM, Strobel SA, Walker GC & Warner IM (2011). Science education. Changing the culture of science education at research universities. Science (New York, N.Y.). Vol. 331, 152-3. Published, 01/01/2011.

Research Statement

            Our research has focused on venomous marine snails, in particular, those belonging to the genus Conus (“cone snails”).  Cone snails are highly specialized venomous predators.  We estimate that there are over 100,000 pharmacologically-active peptides in cone snail venoms, and well over 2,000,000 natural products in the venoms of all venomous marine snails (in the superfamily Conoidea). The major research project in our laboratory is the characterization of these venom components and the identification of their molecular targets, and exploration of potential biomedical applications. 

            The detailed molecular mechanisms underlying the capture of fish by the ca. ~100 fish-hunting cone snail species are being elucidated in considerable detail by our laboratory; most (but not all) active components in these venoms are small peptides (12-30AA), mostly targeted to ion channels and receptors in the nervous system.  One of the peptides isolated by a University of Utah undergraduate in our laboratory has become an approved drug for intractable pain. Recently, we have discovered a novel source of previously inaccessible venomous snails, providing access to a much greater chemical diversity.  The study of cone snails and their venom components has expanded our interests into addressing more general issues in chemical ecology and biodiversity research.