You Han Bae
  • Adjunct Professor, Biomedical Engineering
  • Distinguished Professor, Pharmaceutical Chemistry

Research Keywords

  • Protein drug stabilization and controlled release
  • Polymeric systems for rechargeable cell delivery
  • Self-assembled super intelligent nanoparticulates for sensitive and resistant tumor targeting

Presentations

  • Progress in diabetes therapies, 31st Annual Meeting of Controlled Release Society, Honolulu, Hawaii. , , 2004.
  • Drug incorporated implant, NIDDK, NIBIB and JDRFI Workshop of Immunobarriers for Pancreatic Transplantation, Washington, DC. , , 2004.
  • Caged pancreatic islet for IDDM, Yonsei Biomedical Symposium 2004 on Current Perspectives in Cell Based Therapy, Seoul, Korea. , , 2004.
  • Self-assembled pH-sensitive nanogels as an anti-cancer drug carrier, Hydrogel Microsymposium, The 8th Pacific Polymer Conference, Bangkok, Thailand. , , 2003.
  • Engineered pH sensitive polymeric nanoparticle for tumor chemotherapy, Celebration of Allan Hoffman Accomplishments, Maui, Hawaii. , , 2002.
  • Functional Polymers for Caged Pancreatic Islets, 5th International Meeting of the Tissue Engineering Society International (TESI) in conjunction with the Japanese Society for Tissue Engineering (JSTE) and the Asian Tissue Engineering Society (ATES), Kobe, Japan. , , 2002.
  • Polymeric nanoparticles responding to tumor pH for effective solid tumor chemotherapy, The 11th Functional Polymer Materials Workshop on Nano-biomaterials for drug, gene and cell therapy, Daejeon, Korea. , , 2002.
  • pH-Sensitive polymer for solid tumor targeting, The 3rd Asian International Symposium on Polymeric Biomaterials Science and Drug Delivery, Taipei, Taiwan. , , 2002.
  • Polymeric nanoparticles responding to tumor pH, The seventh European Symposium on Controlled Drug Delivery, Noordwijk ann Zee, The Netherlands. , , 2002.
  • Stimuli-induced sol-gel transition of aqueous solutions of synthetic polymers and its biorelated applications, Microsymposium on Sensitive Polymers and Smart Gels, 7th Pacific Polymer Conference, Oaxaca, Mexico. , , 2001.
  • Functional polymers for pancreatic islet delivery, The IId Volgograd East Asian Symposium on Polymers for Advanced Technology (EASPAT), Volgograd, Russia. , , 2001.
  • Toward a replenishable compact biohybrid artificial pancreas, the 9th annual short course on Advances in Tissue Engineering, Rice University, Houston. , , 2001.
  • Gels and nanoparticulates responsive to physiological pH, The 28th International Symposium on Controlled Release of Bioactive Materials, San Diego, USA. , , 2001.
  • Caged cells, "Barriers to entry" Conference: Davidson Conference Center, University of Southern California. , , 2001.
  • Recent Progress in rechargeable biohybrid artificial pancreas, International Symposium on Biomaterials and Drug Delivery Systems, in conjunction with 2nd Asian International Symposium on Polymeric Biomaterials Science, Cheju Island, Korea. , , 2000.
  • Polymers containing sulfonamide and sulfonylurea groups: Their pH-responsiveness and biospecific function (special lecture), 40th Microsymposium of 2000 Prague Meeting on Macromolecules, Polymers in Medicine, Prague, Czech Republic. , , 2000.
  • Sulfonamide containing polymers: A novel class of pH-responsive polymers and gels, Post- IPC 99 (7th SPSJ International Polymer Conference) Workshop, Let's Meet Novel Gels, Yokohama, Japan. , , 1999.
  • Improvement of pancreatic islet functionality for transplantation, The 6th International Symposium on Biomaterials and Tissue Engineering, Taegu, Korea. , , 1999.
  • Polymeric system for rechargeable biohybrid artificial pancreas, The 4th Asia-Pacific Conference on Medical and Biological Engineering, Seoul, Korea. , , 1999.
  • Glucose Sensor (keynote lecture), Macro 98, IUPAC, Gold Coast, Australia. , , 1998.
  • Polymeric Elastomer soluble in environmentally-friendly solvents: A tip for conducting polymer blendings?, Workshop on "Processing Conducting Polymer Materials and Devices", University of Wollongong, Australia. , , 1998.
  • Biodegradable amphiphilic multiblock copolymers and their implication to biomedical applications, 5th European Symp. on Control. Drug Del., Nordwijk, Aan Zee., Netherlands. , , 1998.
  • Amphiphilic multiblock copolymers: A novel thermoresponsive hydrogel elastomer, 5th Pacific Polymer Conference, Kyongju, Korea. , , 1997.
  • Rechargeable cell delivery system, KSP and CRS Joint Symp. on Recent Adv. in Drug Del. And Biomater., Seoul, Korea. , , 1997.
  • Temperature sensitive polymers, Advances in Intelligent Polymer Research, Wollongong, Australia. , , 1997.
  • Aqueous LCST polymer blends for thermally reversible gelation without hysteresis, 1st Asian Symp. on Polymeric Biomaterials Science, Ishikawa, Japan. , , 1997.
  • Extracellular matrix for a rechargeable cell delivery system, 8th Intern. Symp. On Recent Adv. in Drug Del. Sys., Salt Lake City, USA. , , 1997.
  • Thermoplastic biodegradable hydrogels: Star-shaped block copolymer for polypeptide drug delivery, 212th Am. Chem. Soc. Meeting, Orlando, USA. , , 1996.
  • Hydrogels for cell delivery, 1996 Control. Rel. Soc. Workshop on Development of Hydrogel Dosage Forms, Kyoto, Japan. , , 1996.
  • Application of temperature-sensitive polymers to protein and cell delivery, Workshop on Multifunctional Polymers and Smart Polymer Systems, Wollongong, Australia. , , 1996.
  • Thermally reversible polymer gels for biohybrid artificial pancreas, 36th Microsymp. on High-Swelling Gels, Prague, Czech Republic. , , 1995.
  • N-isopropylacrylamide-based thermosensitive hydrogels: Macromolecular drug loading and release, Intern. Symp. On Biomaterials and Drug Delivery Systems, Seoul. Korea. , , 1994.
  • Stimuli sensitive polymers for macromolecular drug delivery, Sapporo Symp. on Intel. Polym. Gels, Sapporo, Japan. , , 1994.
  • Sulfonyl urea grafted polymers for stimulation of islets of Langerans, 208th Am. Chem. Soc. Meeting, Washington, D. C., USA. , , 1994.
  • Polypeptide drug loading and release using stimuli sensitive hydrogels, 6th Intern. Sympo. On Rec. Adv. In Drug Delivery Systems, Salt Lake City, USA. , , 1993.
  • Pulsatile solute release from polymeric matrices by external stimuli, 1992 Anual Fall Meeting of Biomed. Eng. Soc., Salt Lake City, USA. , , 1992.
  • Pulsatile drug delivery by electric stimulus, 204th Am. Chem. Soc. Meeting, Washington, D. C., USA. , , 1992.
  • Controlled release of macromolecules from electrical and chemical sensitive hydrogels, 34th IUPAC Intern. Symp. on Macromolecules, Prague, Czech Republic. , , 1992.
  • Hydrophilic/hydrophobic tailored copolymers for biomedical applications, Asian Chemical Congress '87 Seoul, Seoul, Korea. , , 1987.

Languages

  • English, Fluent.
  • Korean, Fluent.
    Native.

Publications

  • Nichols JW, Bae YH (date unknown). Odyssey of a cancer nanoparticle: from injection site to site of action. Vol. 7, 606-618. Accepted, .
  • Hu J, Miura S, Na K, Bae YH (date unknown). pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment. Vol. 172, 69-76. Accepted, .
  • Kim D, Lee ES, Oh KT, Gao ZG, Bae YH (date unknown). Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Vol. 4, 2043-50. Accepted, .
  • Yim H, Park SJ, Bae YH, Na K (date unknown). Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Vol. 34, 7674-82. Accepted, .
  • Qiu LY, Bae YH (date unknown). Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Vol. 28, 4132-42. Accepted, .
  • Bae YH (date unknown). Apoptosis-targeted drug delivery. Vol. 154, 213. Accepted, .
  • Lee YJ, Kang HC, Hu J, Nichols JW, Jeon YS, Bae YH (date unknown). pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments. Vol. 13, 2945-51. Accepted, .
  • Kim D, Gao ZG, Lee ES, Bae YH (date unknown). In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Vol. 6, 1353-62. Accepted, .
  • Kim D, Lee ES, Park K, Kwon IC, Bae YH (date unknown). Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Vol. 25, 2074-82. Accepted, .
  • Na K, Lee ES, Bae YH (date unknown). Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells. Vol. 18, 1568-74. Accepted, .
  • Mohajer G, Lee ES, Bae YH (date unknown). Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Vol. 24, 1618-27. Accepted, .
  • Bae YH, Park K (date unknown). Targeted drug delivery to tumors: myths, reality and possibility. Vol. 153, 198-205. Accepted, .
  • Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH (date unknown). Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. Vol. 129, 228-36. Accepted, .
  • Oh KT, Lee ES, Kim D, Bae YH (date unknown). L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Vol. 358, 177-83. Accepted, .
  • Gao ZG, Tian L, Hu J, Park IS, Bae YH (date unknown). Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. Vol. 152, 84-9. Accepted, .
  • Mishra D, Kang HC, Bae YH (date unknown). Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Vol. 32, 3845-54. Accepted, .
  • Park KM, Kang HC, Cho JK, Chung IJ, Cho SH, Bae YH, Na K (date unknown). All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control. Vol. 30, 2642-52. Accepted, .
  • Kang HC, Samsonova O, Bae YH (date unknown). Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells. Vol. 31, 3071-8. Accepted, .
  • Sethuraman VA, Lee MC, Bae YH (date unknown). A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Vol. 25, 657-66. Accepted, .
  • Kim KS, Park W, Hu J, Bae YH, Na K (date unknown). A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle. Vol. 35, 337-43. Accepted, .