You Han Bae
  • Adjunct Professor, Bioengineering
  • Professor, Pharmaceutical Chemistry

Research Keywords

  • gene delivery for obesity control
  • Predictive Preclinical Models of Cancer
  • Self-assembled super intelligent nanoparticulates for sensitive and resistant tumor targeting
  • Protein drug stabilization and controlled release

Presentations

  • Challenges in targeted drug delivery, Drug Delivery and Cancer: Challenges and New Directions for Cancer Therapy, Purdue University, West Lafayette, Oct. 12-14, 2011. Invited Talk/Keynote, Presented, 10/2012.
  • Therapeutic Nanomedicine: Preclinical results vs. clinical outcomes, 2012 Global RNAi Initiative Symposium, Prospects and Development of siRNA Delivery System, KIST, Seoul, July 6, 2012. Invited Talk/Keynote, Presented, 07/2012.
  • EPR effect: Is it homogeneous and predictable for solid tumors in clinics? CRC Nanomedicine Roundtable and Focus Group, Quebec, Canada, July 17, 2012. Invited Talk/Keynote, Presented, 07/2012.
  • Intratumoral transport and microenvironment, CRS Educational workshop: Critical appraisal of EPR Effect and Intratumoral Distribution of Nanomedicines, Quebec, Canada, July 14, 2012. Invited Talk/Keynote, Presented, 07/2012.
  • Polymeric nucleic acid carriers: current issues and novel design approaches, 12th European Symposium on Controlled Drug Delivery, Egmond, aan Zee, The Netherlands, April 4-6, 2012. Invited Talk/Keynote, Presented, 04/2012.
  • pH-sensitive cancer nanomedicine, 6th International Symposium on Intelligent Drug Delivery System, Seoul, Korea, March 14-17, 2011. Invited Talk/Keynote, Presented, 03/2012.
  • Polymeric drug carriers: Current paradigm and prospective, PPC12, Jeju, Korea, Nov. 13-17, 2011. Invited Talk/Keynote, Presented, 11/2011.
  • Novel design concepts for nucleic acid nanovectors, 5th IEEE International Conference on Nano/Molecular Medicine and Engineering, Jeju, Korea, Nov. 9-12, 2011. Invited Talk/Keynote, Presented, 11/2011.
  • Novel design concepts for nucleic acid nanocarriers, NanoDDS’11, Salt Lake City, Oct. 15-Oct 16, 2011. Invited Talk/Keynote, Presented, 10/2011.
  • pH-Responsive polysulfonamide as new functional biomaterials, Asian Biomaterials (3rd ABMC), Busan, Korea, Sept.15-17 2011. Invited Talk/Keynote, Presented, 09/2011.
  • pH-Responsive polysulfonamide as new functional biomaterials, Asian Biomaterials (3rd ABMC), Busan, Korea, Sept.15-17, 2011. Invited Talk/Keynote, Presented, 09/2011.
  • pH-sensitive oligosulfonamide as a new component for polymeric gene vector, Utah-Inha Center symposium, Incheon, Korea, June 10, 2011. Invited Talk/Keynote, Presented, 06/2011.
  • pH-sensitive oligosulfonamide as a new component for polymeric gene vector, Utah-Inha Center symposium, Incheon, Korea, June 10, 2011. Invited Talk/Keynote, Presented, 06/2011.
  • Targeted drug delivery: Current paradigm and prospective, International Symposium on Functional Polymers for Nanomedicine (ISFPN), Hangzhou, China, May 15-18, 2011. Invited Talk/Keynote, Presented, 05/2011.
  • Novel design concepts for nucleic acid nanocarriers, A3 meeting, Guilin, China, May 29-June 2, 2011. Invited Talk/Keynote, Presented, 05/2011.
  • Stimuli-sensitive drug delivery systems, Symposium on Innovative Polymers for Controlled Delivery, Suzhou, China, September 14-17, 2010. Invited Talk/Keynote, Presented, 09/2010.
  • Symposium on “Multifunctional Nanoparticles for Drug Delivery and Imaging”, ACS Annual Fall Meeting, Boston, August 22-26, 2010 (PMSE division). Invited Talk/Keynote, Presented, 08/2010.
  • Smart cancer nanotechnology, Nano-, Bio-, Info-Tech Sensors and Systems, Part of the SPIE International Symposium on The 16th International Symposium on: Smart Structures and Materials & Nondestructive Evaluation and Health Monitoring, Town and Country Resort & Convention Center, San Diego, California, March 7-11, 2010. <Keynote speaker>. Invited Talk/Keynote, Presented, 03/2010.
  • Cancer drug targeting: Current paradigm and prospective, 2009 KCRS annual Conference, Research Networking for Future Therapy, Jeju, Korea, Aug.27-28, 2009. Invited Talk/Keynote, Presented, 2009.
  • pH-Responsive cancer nanotechnology: Tumor heterogeneity and multidrug resistance, 39th annual meeting Korean Society of Pharmaceutical Sciences and Technology (KSPST), Daegu, Korea, Nov. 19-20, 2009. Invited Talk/Keynote, Presented, 2009.
  • pH targeting for cancer therapy, 2009 International Advanced Drug Delivery Symposium, National Ching Hua University, Hsinchu, Taiwan, April 29-30, 2009. Invited Talk/Keynote, Presented, 2009.
  • Bioactive polymers for caged pancreatic islets, The International Workshop on Biomaterials 2009, Changchun, China, Sept 13-18, 2009. Invited Talk/Keynote, Presented, 2009.
  • pH-responsive nanomedicine to overcome multidrug resistance and tumor heterogeneity, BioChip2009, Recent Trends in Nanomedicine”, Seoul, Korea, Oct. 8-9, 2009 (opening keynote lecture). Invited Talk/Keynote, Presented, 2009.
  • H. Yin, E.S. Lee, K.T. Oh, D.I. Kim, Y.H. Bae*, Physicochemical properties of pH-sensitive poly(L-histidine)-b-poly(ethylene glycol)/ poly(L-lactide)-b-poly(ethylene glycol) mixed micelles, J. Control. Rel., 2008, 126(2), 130-138. Conference Paper, Other, 2008.
  • Recent progress in tumor pH targeting nanotechnology, The 10th European Symposium on Controlled Drug Delivery, Noordwijk aan Zee, The Netherlands, April 2-4, 2008. Invited Talk/Keynote, Presented, 2008.
  • Functionalized polymeric gene vector for insulin secreting cells, The 6th Asia 3 China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials, Sanya, Hainan, China, Nov. 26-30, 2008. Invited Talk/Keynote, Presented, 2008.
  • Intelligent gel for pulsatile drug release: from macro- to nano systems. The 4th International Symposium on Advanced Hydrogel for Biomedical Application, Taegu, Korea, March 14-15, 2008. Invited Talk/Keynote, Presented, 2008.
  • Cancer micelle technology, toward a universal system, The 2nd Inha Nono-Clinic Symposium, Recent Advances in Nanomedicine” Seoul, Korea, May 16, 2008. Invited Talk/Keynote, Presented, 2008.

Research Groups

  • Sun Jin Kim, Graduate Student. pharmaceutics and pharmaceutical chemistry. 08/25/2012 - present.
  • Hong Suk Park, Graduate Student. Bioengineering. 08/2010 - present.
  • Joseph Nichol, Graduate Student. Bioengineering. 08/2010 - present.
  • Darrel Stirland, Graduate Student. Bioengineering. 07/2010 - present.
  • Hee Sook Hwang, Graduate Student. Pharmaceutics. 01/2010 - present.
  • Han Chang Kang, Research Professor. 07/2009 - present.
  • Jun Hu, Postdoc. 04/2009 - present.
  • Li Tian, Graduate Student. Pharmaceutics. 08/2006 - present.

Languages

  • English, fluent.
    Korean is a mother tongue.

Geographical Regions of Interest

  • China
  • Japan
  • Republic of Korea

Publications

  • J.W. Nichols, Y.H. Bae*, Odyssey of a cancer nanoparticle: from injection site to site of action, Nanotoday, 2012, 7(6), 606-618. Published, 12/2012.
  • W. Park, D. Kim, H.C. Kang, Y.H. Bae*, K. Na*, Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere, Biomaterials 2012, 33(34), 8848-8857. Published, 12/2012.
  • H.C. Kang, K.M. Huh, Y.H. Bae*, Polymeric nucleic acid carriers, Current issues and novel design approach, J. Controlled Release, 2012, 164, 256-264. Published, 12/2012.
  • T. Denison, Y.H. Bae*, Tumor heterogeneity and its implication to drug delivery, J. Control. Rel., 2012, 164, 187-191. Published, 12/2012.
  • L. Tian, Y.H. Bae*, Cancer nanomedicines targeting tumor extracellular pH, Colloids and Surfaces B: Biointerfaces 2012, (99), 116-126. Published, 11/2012.
  • Y.J. Lee, H.C. Kang, J. Hu, J.W. Nichols, Y.H. Bae*, pH-sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments, Biomacromol. 2012, 13(9), 2945-2951. Published, 09/2012.
  • H. Yin, H.C. Kang, K.M. Huh, Y.H. Bae*, Biocompatible histidine-based AB2 miktoarm star copolymer polymersome: Synthesis, characterization, and acidic pH-activated transformation, J. Mater. Chem. 2012, 22(36), 19168-19178. Published, 09/2012.
  • V. Nadithe, D. Mishra, Y.H. Bae*, Poly(ethylene glycol) cross-linked hemoglobin with antioxidant enzymes protects pancreatic islets from hypoxic and free radical stress and extends the islet functionality, Bioeng. Biotech. 2012, 109(9), 2392-2401. Published, 09/2012.
  • Y.H. Bae*, Ligand-mediated vs. ‘passive’ targeting approaches in oncology research, Therapeutic Delivery, 2012, 3(8), 933-936. Published, 08/2012.
  • H.C. Kang, J.E. Lee, Y.H. Bae*, Nanoscaled buffering zone of charged (PLGA)n-b-bPEI micelles in acidic microclimate for potential protein delivery application, J. Controlled Release, 2012, 160(3), 440-450. Published, 06/2012.
  • K.M. Huh, H.C. Kang, Y.J. Lee, Y.H. Bae*, pH-Sensitive polymers for drug delivery, Macromol. Res. 2012, 20, 224-233. Published, 03/2012.
  • H.C. Kang, O. Samsonova, S.W. Kang, Y.H. Bae*, The effect of environmental pH on polymeric transfection of cancer cells, Biomaterials, 2012, 33(5), 554-563. Published, 02/2012.
  • H. Yin, Y.H. Bae, pH-triggered micelles, in Kratz, Senter, Steinhagen (Eds.), Drug Delivery in Oncology. From basic researches to cancer therapy, Wiley-VCH, 2011, pp. 1099-1131. Published, 01/2012.
  • V. Nadithe, Y.H. Bae*, Hemoglobin conjugates with antioxidant enzymes via poly(ethylene glycol) cross-linker (Hb-SOD-CAT) for protection of isolated cells in hypoxia. Tissue Eng., Part A, 2011, 17, 2453-2462. Published, 10/2011.
  • H. Kim, J. Lee, T.H. Kim, E.S. Lee, K.T. Oh, D.H. Lee, E.S. Park, Y.H. Bae, K.C. Lee, Y.S. Youn YS*, Albumin-coated oorous hollow poly(lactic-co-glycolic Acid) microparticles bound with palmityl-acylated Exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes., Pharm. Res., 2011, 28, 2008-2019. Published, 08/2011.
  • H. Yim, S.-G. Yang, Y.S. Jeon, I.S. Park, M. Kim, D.H. Lee, Y.H. Bae, K. Na*, The performance of gadolinium diethylene triamine pentaacetate-pullulan hepatocyte-specific T1 contrast agent for MRI, Biomaterials, 2011, 32, 5187-5194. Published, 08/2011.
  • Y.H. Bae, K. Park, Targeted Drug Delivery to Tumors: Myths, Reality, and Possibility, J. Control. Release, 2011, 153, 198-205. Published, 08/2011.
  • H.C. Kang, Y.H. Bae, Co-delivery of small interfering RNA and plasmid DNA by polymeric vector incorporated with endosomolytic oligomeric sulfonamides, Biomaterials, 2011, 32, 4914-4924. Published, 07/2011.
  • D. Mishra, H.C. Kang, Y.H. Bae, Reconstitutable charged polymeric micelle for gene therapeutics delivery, Biomaterials, 2011, 32, 3845-3854. Published, 05/2011.
  • Z.G. Gao, L. Tian, J. Hu, I.S. Park, Y.H. Bae*, Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles, J. Control. Rel., 2011 152. 84-89. Published, 05/2011.
  • H.C. Kang, H.-J. Kang, Y.H. Bae*, A Reducible polycations from low molecular weight branched polyethleneimine for genetic therapeutics delivery, Biomaterials, 2011, 32, 1193-1203. Published, 02/2011.
  • V. Nadithe, Y.H. Bae*, Synthesis and characterization of hemoglobin conjugates with antioxidant enzymes via poly(ethylene glycol) cross-linker (Hb-SOD-CAT) for protection from free radical stress, International Journal of Biological Macromolecules 2010, 47, 603-613. Published, 12/2010.
  • H.C. Kang, Y.H. Bae, Endolysosomolytically active pH-sensitive polymeric nanotechnology, “Organelle-Specific Pharmaceutical Nanotechnology” edited by Weissig and D’Souza. Wiley & Sons, Inc, 2010, pp 247-262. Published, 12/2010.
  • H. Yin, Y.H. Bae, pH-triggered micelles, in Kratz, Senter, Steinhagen (Eds.), Drug Delivery in Oncology. From basic researches to cancer therapy, Wiley-VCH. Accepted, 08/2010.
  • J.H. Maeng, D.H. Lee, K.H. Jung, Y.H. Bae, I.S. park, S. Jeong, Y.S. Jeon, C.K. Shim, W. Kim, J.A. Kim, J. Lee, Y.M. Lee, J.H. Kim, W.H. Kim, and S.S. Hong*, Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer, Biomaterials, 2010, 31, 4995-5006. Published, 06/2010.
  • H.C. Kang, O. Samsonova, Y.H. Bae, Trafficking microenvionmental pH of polycationic gene vectors in drug-sensitive and multidrug resistant MCF-7 breast cancer cells, Biomaterials, 2010, 31, 3071-3078. Published, 04/2010.
  • D. Kim, Y.H. Bae, Polymeric carriers for anticancer drugs, in Yi Lu, Ram I. Mahato (Eds.), Pharmaceutical Perspectives of Cancer Therapeutics, Springer, New York, USA. 2009, pp.207-244. Published, 12/2009.
  • Y.S. Youn, K.C. Lee, Y.H. Bae, K. Na, E.S. Lee, Advanced pulmonary delivery of peptides or proteins using polymeric particles, in L. Jorgenson and H. M. Nielson (Eds.), Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Wiley & Sons, Ltd., West Sussex, United Kingdom, 2009, pp.227-244. Submitted, 12/2009.
  • Y.H. Bae, Drug targeting and tumor heterogeneity, J. Control. Rel., 2009, 133, 2-3. Published, 2009.
  • H. Yin, Y.H. Bae, Physicochemical aspects of doxorubicin-loaded pH-sensitive polymeric micelle formulations, Eur. J. Pharm. Biopharm. 2009, 71, 223-230. Published, 2009.
  • H. Yin, S.-W. Kang, Y.H. Bae, Polymersome formation from AB2 type 3-miktoarm star copolymers, Macromolecules, 2009, 42(19), 7456-7464. Published, 2009.
  • D. Kim, Z. Gao, E.S. Lee, Y.H. Bae, In vivo evaluation of doxorubicin loaded polymeric micelle targeting folate receptor and early endosomal pH with drug resistant ovarian cancer, Mol. Pharm. 2009, 6(5), 1353-1362. Published, 2009.
  • H.C. Kang, Y.H. Bae*, Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector, Biomaterials, 2009, 30, 2837-2845. Published, 2009.
  • K.M. Park, H.C. Kang, J.K. Cho, I.-J. Chung, S.-H. Cho, Y.H. Bae, and K. Na, All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control, Biomaterials 2009, 30, 2642-2652. Published, 2009.
  • S.-W. Kang and Y.H. Bae, Cryopreservable and tumorigenic three dimensional tumor culture in porous poly(lactic-co-glycolic acid) microsphere, Biomaterials 2009, 30, 4227-4232. Published, 2009.
  • H.C. Kang, Y.H. Bae, Transfection of rat pancreatic islet tissue by polymeric gene vectors, Diab. Tech. & Thera. 2009, 11, 443-449. Published, 2009.
  • E.S. Lee, Y.H. Bae*, Recent Progress in Tumor pH Targeting, J. Control Rel., 2008, 132, 164-170. Published, 12/2008.
  • H.C. Kang, E.S. Lee, K. Na, Y.H. Bae, Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery, in Vladimir P. Torchilin (Ed), Series: Fundamental Biomedical Technologies, Vol. 4. Multifunctional Pharmaceutical Nanocarriers, Springer, New York, USA. 2008, pp. 161-199. Published, 12/2008.
  • D. Kim, E.S. Lee, K.T. Oh, Z. Gao, Y.H. Bae*, Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH, Small 2008, 4, 2043-2050. Published, 11/2008.
  • D. Kim, E.S. Lee, K.S. Park, I.C. Kwon, Y.H. Bae*, Doxorubicin loaded pH-sensitive mixed micelle: antitumoral efficacy against ovarian A2780/DOXR tumor, Pharm. Res., 2008, 25, 2074-2082. Published, 09/2008.
  • E.S. Lee, Z. Gao, D. Kim, K. Park, I.C. Kwon, Y.H. Bae*, Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance, J. Control. Rel. 2008, 129, 228-236. Published, 08/2008.
  • Y.H. Bae*, H. Yin, Stability issues of polymeric micelles (perspective), J. Control. Rel. 2008, 131, 2-4. Published, 08/2008.
  • B.S. Jin, H.C. Kang, D. Kim, K.H. Lee, Y.H. Bae*, Synthesis of poly(cystine bisamide)-PEG block copolymers grafted with 1-(3-aminopropyl) imidazole and their phase transition behaviors, Polymer for Advanced Technologies, 2008, 19, 1558-1565. Published, 07/2008.
  • A. Taluja, Y.S. Youn, Y.H. Bae*, Role of a novel multifunctional excipient poly(ethylene glycol)-b-oligo (vinyl sulfadimethoxine) in protein delivery from poly(lactide-co-glycolide) microspheres, Int. J. Pharm. 2008, 358(1-2), 50-59. Published, 06/2008.
  • K.T. Oh, E.S. Lee, D.I. Kim, H. Yin, Y.H. Bae*, L-Histidine based pH-sensitive anticancer drug carrier micelle: Reconstitution and brief evaluation of its systemic toxicity, Int. J. Pharm. 2008, 358(1-2), 177-183. Published, 06/2008.
  • V.A. Sethuraman, M.C. Lee, Y.H. Bae*, A biodegradable pH-sensitive micelle system for targeting acidic solid tumors, Pharm. Res. 2008, 25(3), 657-666. Published, 03/2008.
  • E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H Bae*, A virus-mimetic nanogel vehicle, Angew. Chem. Int. Ed., 2008, 47(13), 2418-2421. Published, 03/2008.