JAMES P KEENER portrait
  • Adjunct Professor, Biomedical Engineering
  • Distinguished Professor, Mathematics

Publications

  • Fogelson AL & Nelson AC (2022). DEVELOPMENT OF FIBRIN BRANCH STRUCTURE BEFORE AND AFTER GELATION. SIAM journal on applied mathematics. Vol. 82, 267293267-293. Published, 09/01/2022.
  • Doyle MG & Chugunova M (2021). Lumped parameter models for two-ventricle and healthy and failing extracardiac Fontan circulations. Mathematical medicine and biology : a journal of the IMA. Vol. 38, 442466442-466. Published, 12/01/2021.
  • Poelzing S (2021). Initiation and entrainment of multicellular automaticity via diffusion limited extracellular domains. Biophysical journal. Vol. 120, 527952945279-5294. Published, 12/01/2021.
  • Lewis OL (2021). Principles of slowed hydrogen diffusion through a mucus layer. Physical review. E. Vol. 104, 044403044403. Published, 11/01/2021.
  • Lewis OL (2021). ENHANCED ELECTRODIFFUSIVE TRANSPORT ACROSS A MUCUS LAYER. SIAM journal on applied mathematics. Vol. 81, 965981965-981. Published, 06/01/2021.
  • FitzGerald CE (2021). The PafBC-mediated response sensitizes a bistable DNA damage response in Mycobacteria. Journal of theoretical biology. Vol. 508, 110462110462. Published, 06/01/2021.
  • Ma J (2020). The computation of biomarkers in pharmacokinetics with the aid of singular perturbation methods. Journal of mathematical biology. Vol. 77, 140714301407-1430. Published, 03/01/2020.
  • Nelson AC (2020). Kinetic model of two-monomer polymerization. Physical review. E. Vol. 101, 022501022501. Published, 03/01/2020.
  • Fogelson B (2019). Enhanced Nucleocytoplasmic Transport due to Competition for Elastic Binding Sites. Biophysical journal. Vol. 115, 108116108-116. Published, 08/01/2019.
  • Osunbayo O, Miles CE & Doval F (2019). Complex nearly immotile behaviour of enzymatically driven cargos. Soft matter. Vol. 15, 184718521847-1852. Published, 03/01/2019.
  • Miles CE (2018). Bidirectionality from cargo thermal fluctuations in motor-mediated transport. Journal of theoretical biology. Vol. 424, 374837-48. Published, 03/01/2018.
  • Lewis OL (2017). A physics-based model for maintenance of the pH gradient in the gastric mucus layer. American journal of physiology. Gastrointestinal and liver physiology. Vol. 313, G599G612G599-G612. Published, 12/01/2017.
  • Lawley SD & Keener JP (2016). Including Rebinding Reactions in Well-Mixed Models of Distributive Biochemical Reactions. Biophysical Journal. Vol. 111, 2317-2326. Published, 11/01/2016.
  • Veeraraghavan R, Lin J, Keener JP, Gourdie R & Poelzing S (2016). Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study. Pflugers Archiv : European journal of physiology. Vol. 468, 1651-61. Published, 09/01/2016.
  • V. Camacho, A. L. Fogelson, and J. P. Keener, Eulerian-Lagrangian treatment of non-dilute two-phase gels, SIAM J. Appl. Math. 76, pp. 341-367 (2016). Published, 02/2016.
  • George SA, Sciuto KJ, Lin J, Salama ME, Keener JP, Gourdie RG & Poelzing S (2015). Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene. Pflugers Archiv : European journal of physiology. Vol. 467, 2287-97. Published, 10/01/2015.
  • Veeraraghavan R, Lin J, Hoeker GS, Keener JP, Gourdie RG & Poelzing S (2015). Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Pflugers Archiv : European journal of physiology. Vol. 467, 2093-105. Published, 09/01/2015.
  • Shtylla B & Keener JP (2015). Mathematical modeling of bacterial track-altering motors: Track cleaving through burnt-bridge ratchets. (pp. 042711). Vol. 91. Physical review. E, Statistical, nonlinear, and soft matter physics. Published, 05/01/2015.

Research Statement

My primary research interest is in developing and analysing mathematical models of physiological processes. Although my biological interests are wide ranging, the unifying theme is the identification and application of mathematical principles of dynamical systems to biological processes. Some of the problems on which I have worked recently include initiation and termination of cardiac arrhythmias, quorum sensing by bacteria, pattern formation in biofilms, stochastic behavior of neural action potentials and of calcium release events, size regulation of filaments of molecular motors, and propagation of action potentials in cardiac tissue.