Presentations

• NOMADS (Neuropsychiatric Movement and Associated Disorders) Working Group, University of Utah "Exploring potential pharmacotherapies to manage consequences of striatal dopamine loss on phasic DA transmission and cellular and behavioral functions of the basal ganglia" . Presentation, Presented, 04/17/2013.
• Son., J-H., Leavitt, L., and Keefe, K.A. Impairment of withholding a “pre-potent” response in rats with METH-induced neurotoxicity. Program No. 360.01. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Keefe, K.A., Pastuzyn, E.D., Oldenburger, K., Pelton, B., and Barker-Haliski, M.L. L-DOPA treatment restores impaired basal ganglia gene expression in rats with methamphetamine-induced neurotoxicity. Program No. 360.04. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Barker-Haliski, M.L. and Keefe, K.A. Partial monoamine loss induced by methamphetamine impairs Arc/Arg 3.1 and zif268/egr1 mRNA expression and subcellular localization in striatal efferent neurons. Program No. 360.02. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Friend, D.M. and Keefe, K.A. Glial reactivity in repeated methamphetamine exposure. Program No. 360.07. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Fleckenstein, A.E., Keefe, K.A., German, C.L., Friend, D.M., Hanson, G.R., Fricks-Gleason, A.N. Identification of a novel change in the dopamine transporter induced by a repeated, high-dose methamphetamine neurotoxic regimen of methamphetamine. Program No. 42.08. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Fricks-Gleason, A.N., Keefe, K.A. Evaluating the role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity. Program No. 360.06. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Howard, C.D., Keefe, K.A., Daberkow, D.P., Ramsson, E., Garris, P.A. Methamphetamine-induced neurotoxicity diminishes phasic dopamine activity in the striatum of freely moving rats. Program No. 360.03. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Pastuzyn, E.D. and Keefe, K.A. Partial methamphetamine-induced striatal dopamine loss results in a change in circuitry mediating Arc-regulated response reversal learning. Program No. 360.05. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Poster, Presented, 10/2012.
• Dept. of Molecular Pharmacology, Rosalind Franklin University of Medicine and Science. Invited seminar speaker, "What a METH: Long-term consequences of METH-induced partial DA loss on phasic DA neurotransmission and basal ganglia-mediated learning and memory processes". Invited Talk/Keynote, Presented, 09/27/2012.
• Dept. of Neurosciences, College of Medicine, The University of Toledo. "What a METH: Long-term consequences of METH-induced partial DA loss on phasic DA neurotransmission and basal ganglia-mediated learning and memory processes", August 15, 2012. Invited Talk/Keynote, Presented, 08/15/2012.
• Keefe, K.A., Oldenberger, K., Pastuzyn, E.D., Barker-Haliski, M.L. Chronic L-DOPA treatment restores impaired basal ganglia gene expression in rats with methamphetamine-induced neurotoxicity. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Pastuzyn, E.D. and Keefe, K.A. Partial methamphetamine-induced striatal dopamine loss causes a change in circuitry mediating Arc-regulated response reversal learning. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Barker-Haliski, M.L. and Keefe, K.A. Partial monoamine loss induced by methamphetamine impairs Arc/Arg 3.1 mRNA expression in striatal efferent neurons. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Fricks-Gleason, A.N., Friend, D.M., Keefe, K.A. The role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Son, J.-H., Kuhn, J., and Keefe, K.A. Stereotypic perseverative instrumental behavior associated with methamphetamine-induced neurotoxicity in rats. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Friend, D.M., Fricks-Gleason, A.N., Keefe, K.A. Nitric oxide synthase isoform expression and activity in methamphetamine-induced striatal toxicity. 45th Annual Winter Conference on Brain Research, Snowbird, UT. Poster, Presented, 01/2012.
• Dept. of Physiology and Developmental Biology, Brigham Young University. Invited seminar speaker, "Consequences of Methamphetamine-Induced Neurotoxicity on Molecular and Behavioral Functions of the Basal Ganglia". Sept. 15, 2011. Invited Talk/Keynote, Presented, 09/2011.
• 2011 Gordon Research Conference on Catecholamines, Invited speaker in session on Catecholamines in Neuropsychiatric/Neurological Disorders. "Impairment of learning and memory functions of the basal ganglia by partial dopamine loss induced by methamphetamine", August 7-12, 2011. Invited Talk/Keynote, Presented, 08/2011.
• 44th Winter Conference on Brain Research, invited presented in session entitled "Becoming addicted: The transition to dorsal striatum mediated drug-seeking behavior ", Keystone, CO, January 22-27, 2011. Invited Talk/Keynote, Presented, 01/2011.
• Frye, A.M., Riedy, M.D., Son, J.H., and Keefe, K.A. The formation of stimulus-response and action-outcome associations during cocaine self administration in response to discriminative stimuli or conditioned reinforcers. Soc. Neurosci. Abstr. 575.18, 2010. Poster, Presented, 11/2010.
• Fricks-Gleason, A.N., Friend, D.M., and Keefe, K.A. The role of neuronal nitric oxide synthase-containing interneurons in methamphetamine-induced dopamine neurotoxicity. Soc. Neurosci. Abstr. 577.18, 2010. Poster, Presented, 11/2010.
• Friend, D.M., and Keefe, K.A. Expression of NOS isoforms in methamphetamine-induced striatal dopamine toxicity. Soc. Neurosci. Abstr. 577.17, 2010. Poster, Presented, 11/2010.
• Pastuzyn E.D. and Keefe, K.A. Impact of partial dopamine loss induced by methampheramine on Arc-mediated, striatally based learning. Soc. Neurosci. Abstr. 577.16, 2010. Poster, Presented, 11/2010.
• Barker, M.L. and Keefe, K.A. Arc/Arg3.1 regulation in striatal efferent neurons under normal conditions and in the presence of partial dopamine loss induced by methamphetamine. Soc. Neurosci. Abstr. 577.15, 2010. Poster, Presented, 11/2010.
• Son, J.-H., Garcia, C., and Keefe, K.A. Impaired formation of stimulus-response, but not action-outcome associations in rats with partial dopamine loss induced by methamphetamine neurotoxicity. Soc. Neurosci. Abstr. 577.14, 2010. Poster, Presented, 11/2010.
• Translational Research in Methamphetamine Addiction 2010 meeting. Invited presentation: "Methamphetamine and basal ganglia dysregulation". Invited Talk/Keynote, Presented, 07/2010.
• Pastuzyn E.D. and Keefe, K.A. Impact of partial dopamine loss induced by methampheramine on Arc-mediated, striatally based learning. Translational Research in Methamphetamine Addiction, Pray, MT, July 19-21, 2010. Poster, Presented, 07/2010.
• Friend, D.M., Fricks-Gleason, A.N., Chen. P., Hanson, G.R., and Keefe, K.A. Expression of NOS isoforms in methamphetamine-induced striatal dopamine toxicity. Translational Research in Methamphetamine Addiction, Pray, MT, July 19-21, 2010. Poster, Presented, 07/2010.
• Barker, M.L. and Keefe, K.A. Arc/Arg3.1 regulation in striatal efferent neurons under normal conditions and in the presence of partial dopamine loss induced by methamphetamine. Translational Research in Methamphetamine Addiction, Pray, MT, July 19-21, 2010. Poster, Presented, 07/2010.
• Pastuzyn, E.D. and Keefe, K.A. Impact of partial dopamine loss induced by methampheramine on Arc-mediated, striatally based learning. Tenth Triennial Meeting of the International Basal Ganglia Society, Long Branch, NJ, June 20-24, 2010. Poster, Presented, 06/2010.
• Barker, M.L. and Keefe, K.A. Arc/Arg3.1 regulation in striatal efferent neurons under normal conditions and in the presence of partial dopamine loss induced by methamphetamine. Tenth Triennial Meeting of the International Basal Ganglia Society, Long Branch, NJ, June 20-24, 2010. Poster, Presented, 06/2010.
• Friend, D.M., Fricks-Gleason, A.N., Chen. P., Hanson, G.R., and Keefe, K.A. Expression of NOS isoforms in methamphetamine-induced striatal dopamine toxicity. Tenth Triennial Meeting of the International Basal Ganglia Society, Long Branch, NJ, June 20-24, 2010. Poster, Presented, 06/2010.
• Son, J.-H., Garcia, C., and Keefe, K.A. Effects of methamphetamine neurotoxicity on striatal-dependent stimulus-response learning. Tenth Triennial Meeting of the International Basal Ganglia Society, Long Branch, NJ, June 20-24, 2010. Poster, Presented, 06/2010.
• Dept. of Pharmacology and Toxicology Seminar Series University of Utah "Long-term consequences of methamphetamine-induced neurotoxicity on cellular, systems, and behavioral function of the basal ganglia". Invited Talk/Keynote, Presented, 03/15/2010.

Research Groups

• Ashley Fricks-Gleason, Postdoc. 01/2010 - present.
• Melissa Barker-Haliski, Graduate Student. 08/2009 - 04/2012.
• Danielle Friend, Graduate Student. 07/2009 - present.
• Amber Frye, Technician. 07/2009 - 08/2011.
• Elissa Pastuzyn, Graduate Student. 07/2009 - present.
• Jong-Hyun Son, Postdoc. 05/2009 - present.

Languages

• English, fluent.

Publications

• Perseverative behavior in rats with methamphetamine-induced neurotoxicity. Son JH, Kuhn J, Keefe KA. Neuropharmacology. 2013 Apr;67:95-103. doi: 10.1016/j.neuropharm.2012.09.021. Epub 2012 Nov 14. PMID: 23159331 [PubMed - in process]. Published, 04/2013.
• Expression and activity of nitric oxide synthase isoforms in methamphetamine-induced striatal dopamine toxicity. Friend DM, Son JH, Keefe KA, Fricks-Gleason AN. J Pharmacol Exp Ther. 2013 Feb;344(2):511-21. doi: 10.1124/jpet.112.199745. Epub 2012 Dec 10. PMID: 23230214 [PubMed - indexed for MEDLINE]. Published, 02/2013.
• Disruption of subcellular Arc/Arg 3.1 mRNA expression in striatal efferent neurons following partial monoamine loss induced by methamphetamine. Barker-Haliski ML, Oldenburger K, Keefe KA. J Neurochem. 2012 Dec;123(5):845-55. doi: 10.1111/jnc.12017. Epub 2012 Oct 10. PMID: 22978492 [PubMed - indexed for MEDLINE]. Published, 12/2012.
• Expression of the core exon-junction complex factor eukaryotic initiation factor 4A3 is increased during spatial exploration and striatally-mediated learning. Barker-Haliski ML, Pastuzyn ED, Keefe KA. Neuroscience. 2012 Dec 13;226:51-61. doi: 10.1016/j.neuroscience.2012.09.003. Epub 2012 Sep 12. PMID: 22982623 [PubMed - indexed for MEDLINE]. Published, 12/2012.
• Pastuzyn, E.D. and Keefe, K.A., Altered Arc-regulated striatal learning in rats pretreated with a neurotoxic regimen of methamphetamine. Neuropsychopharmacology, 37(4): 885-895, 2012. Published, 03/2012.
• Son, J-H, Latimer, C., and Keefe, K.A. Impaired formation of stimulus-response, but not action-outcome, associations in rats with methamphetamine-induced neurotoxicity. Neuropsychopharmacology, Nov;36(12):2441-2451, 2011. Published, 11/2011.
• Howard, C.D., Keefe, K.A., Garris, P.A., and Daberkow, D.P. Methamphetamine-induced neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum. The Journal of Neurochemistry, Aug;118(4):668-676. doi:10.1111/j.1471-4159.2011.07342.x. 2011. Published, 08/2011.
• Keefe, K.A. and Horner, K.A. Neurotransmitter Regulation of Basal Ganglia Gene Expression (Chapter 27). In Handbook of Basal Ganglia Structure and Function, a Decade of Progress (H. Steiner and K.Y. Tseng, Eds.), Elsevier, Inc., 2010, pp 461-490. Published, 02/2010.