In 1968, I began development of Structural Analysis of Social Behavior (SASB) for modeling patterns of social interactions with self and others in terms of the underlying dimensions of focus (on other, on self, focus on other turned inward on the self), affiliation (love/ hate), interdependence (enmeshment = control/submit to differentiation = emancipate/separate). Reviews of some research studies appeared in: Benjamin, L.S. (1996). Introduction to the special section on Structural Analysis of Social Behavior (SASB). Journal of Consulting and Clinical Psychology.,64,1203-1212. Benjamin, L. S. , Rothweiler, J.R., & Critchfield, K. L. (2006). Use of Structural Analysis of Social Behavior as an Assessment Tool. Annual Review of Clinical Psychology, 2.] My honorary degree from the University of Umea, Sweden (1998) was for the creation and development of SASB. Clinicial and research uses of the SASB technology led to the conclusion that there are direct connections between patterns of adult personality and earlier patterns practiced in relation to caregivers and other loved ones. From working with patients, and research uses of SASB, Interpersonal Reconstructive Therapy (IRT) emerged. It is based on a case formulation that systematically describes connections between present day personlity and ealier interactive patterns in terms of copy processes usually identified via SASB codes and predictive principles (be like him or her; act as if he or she is still there and in control; treat yourself as you were treated). Current personality patterns also are related to current psychiatric symptoms. For example, resentful submission (helplessness), self criticism, and perceived abandonment support chronic depression. Extreme self control accompanied by constant mobilization in service of perfectionism support chronic anxiety while trying to cope, and is likely to degrade to depression when the quest for perfection seems impossible and the person gives up in despair. In 2003, the IRT treatment model and methods were published [Benjamin, L.S. (2003). Interpersonal Reconstructive Therapy: promoting change in Nonresponders. New York: Guilford Press.] My third book, now in draft [Interpersonal Reconstructive Therapy for Anger, Anxiety and Depression; American Psychological Association] centers on (a) my proposed natural biological theory of psychopathology and (b) use understanding of the natural biology of psychopathology and the IRT case formulation method. The perspective allows the clinician to select optimal ways of engaging the will to progress through Prochaska’s five transtheoretical stages of change. My research, with collaborator Ken Critchfield, shows that therapists who adhere more closely to the IRT therapy model have better outcomes, while nonadherent therapists have less favorable outcomes..