ALPHONSUS HON-CHUNG NG portrait
  • Adjunct Assistant Professor, Molecular Pharmaceutics
  • Assistant Professor, Biomedical Engineering
801-581-8528

Publications

  • Ng AHC, Hu H, Wang K, Scherler K, Warren SE, Zollinger DR, McKay-Fleisch J, Sorg K, Beechem JM & Ragaglia E (2023). Organ-specific immunity: A tissue analysis framework for investigating local immune responses to SARS-CoV-2. Cell reports. Vol. 42, 113212113212. Published, 11/01/2023.
  • Foy SP, Jacoby K, Bota DA, Hunter T, Pan Z, Stawiski E, Ma Y, Lu W, Peng S, Wang CL, Yuen B, Dalmas O, Heeringa K, Sennino B, Conroy A, Bethune MT, Mende I, White W, Kukreja M, Gunturu S, Humphrey E, Hussaini A, An D, Litterman AJ, Quach BB, Ng AHC, Lu Y, Smith C, Campbell KM, Anaya D, Skrdlant L, Huang EY, Mendoza V, Mathur J, Dengler L, Purandare B, Moot R, Yi MC, Funke R, Sibley A, Stallings-Schmitt T, Oh DY, Chmielowski B, Abedi M, Yuan Y, Sosman JA, Lee SM, Schoenfeld AJ, Baltimore D, Heath JR, Franzusoff A, Ribas A, Rao AV & Mandl SJ (2022). Non-viral precision T cell receptor replacement for personalized cell therapy. Nature. Vol. 615, 687–696. Published, 11/10/2022.
    https://www.nature.com/articles/s41586-022-05531-1
  • Wells DK, van Buuren MM, Dang KK, Hubbard-Lucey VM, Sheehan KCF, Campbell KM, Lamb A, Ward JP, Sidney J, Blazquez AB, Rech AJ, Zaretsky JM, Comin-Anduix B, Ng AHC, Chour W, Yu TV, Rizvi H & Chen JM (2021). Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell. Vol. 183, 818834.e13818-834.e13. Published, 05/01/2021.
  • Ng AHC, Peng S, Xu AM, Noh WJ & Guo K (2020). MATE-Seq: microfluidic antigen-TCR engagement sequencing. Lab on a chip. Vol. 19, 301130213011-3021. Published, 10/01/2020.
  • Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K & Kim J (2020). Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell reports. Vol. 28, 27282738.e72728-2738.e7. Published, 09/01/2020.
  • Lu Y, Yoo BK, Ng AHC & Kim J (2020). 4D electron microscopy of T cell activation. Proceedings of the National Academy of Sciences of the United States of America. Vol. 116, 220142201922014-22019. Published, 05/01/2020.
  • Ng AHC, Fobel R, Fobel C, Lamanna J, Rackus DG, Summers A, Dixon C, Dryden MDM, Lam C, Ho M, Mufti NS, Lee V, Asri MAM, Sykes EA & Chamberlain MD (2019). A digital microfluidic system for serological immunoassays in remote settings. Science translational medicine. Vol. 10. Published, 09/01/2019.
  • Abdulwahab S, Ng AHC, Chamberlain MD & Ahmado H (2018). Towards a personalized approach to aromatase inhibitor therapy: a digital microfluidic platform for rapid analysis of estradiol in core-needle-biopsies. Lab on a chip. Vol. 17, 159416021594-1602. Published, 08/01/2018.
  • Dixon C & Ng AH (2018). An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays. Lab on a chip. Vol. 16, 456045684560-4568. Published, 05/01/2018.
  • Ng AH & Li BB (2016). Digital Microfluidic Cell Culture. Annual review of biomedical engineering. Vol. 17, 9111291-112. Published, 09/01/2016.
  • Shamsi MH & Choi K (2016). Electrochemiluminescence on digital microfluidics for microRNA analysis. Biosensors & bioelectronics. Vol. 77, 845852845-52. Published, 09/01/2016.
  • Ng AH (2016). Next-generation microfluidic point-of-care diagnostics. Clinical chemistry. Vol. 61, 123312341233-4. Published, 01/01/2016.
  • Lafrenière NM, Mudrik JM & Ng AH (2015). Attractive design: an elution solvent optimization platform for magnetic-bead-based fractionation using digital microfluidics and design of experiments. Analytical chemistry. Vol. 87, 390239103902-10. Published, 10/01/2015.
  • Mei N & Seale B (2015). Digital microfluidic platform for human plasma protein depletion. Analytical chemistry. Vol. 86, 846684728466-72. Published, 08/01/2015.
  • Fobel R & Kirby AE (2015). Paper microfluidics goes digital. Advanced materials (Deerfield Beach, Fla.). Vol. 26, 283828432838-43. Published, 04/01/2015.
  • Ng AH, Lee M & Choi K (2015). Digital microfluidic platform for the detection of rubella infection and immunity: a proof of concept. Clinical chemistry. Vol. 61, 420429420-9. Published, 04/01/2015.
  • Shamsi MH & Choi K (2014). A digital microfluidic electrochemical immunoassay. Lab on a chip. Vol. 14, 547554547-54. Published, 08/01/2014.
  • Choi K, Ng AH, Fobel R, Chang-Yen DA, Yarnell LE & Pearson EL (2014). Automated digital microfluidic platform for magnetic-particle-based immunoassays with optimization by design of experiments. Analytical chemistry. Vol. 85, 963896469638-46. Published, 08/01/2014.
  • Ng AH & Choi K (2013). Digital microfluidic magnetic separation for particle-based immunoassays. Analytical chemistry. Vol. 84, 880588128805-12. Published, 03/01/2013.
  • Choi K & Ng AH (2012). Digital microfluidics. Annual review of analytical chemistry (Palo Alto, Calif.). Vol. 5, 413440413-40. Published, 10/01/2012.
  • Fiddes LK, Luk VN & Au SH (2012). Hydrogel discs for digital microfluidics. Biomicrofluidics. Vol. 6, 14112141121114112-1411211. Published, 08/01/2012.
  • Miller EM & Ng AH (2011). A digital microfluidic approach to heterogeneous immunoassays. Analytical and bioanalytical chemistry. Vol. 399, 337345337-45. Published, 04/01/2011.
  • Jebrail MJ, Ng AH & Rai V (2011). Synchronized synthesis of peptide-based macrocycles by digital microfluidics. Angewandte Chemie (International ed. in English). Vol. 49, 862586298625-9. Published, 02/01/2011.
  • Ng AH (2010). Immunoassays in microfluidic systems. Analytical and bioanalytical chemistry. Vol. 397, 9911007991-1007. Published, 08/01/2010.

Research Statement

Our research is centered around developing micro-nanotechnologies and computational methods to extract information from biospecimens that are not typically obtainable using conventional methods. Our expertise includes microfluidics, engineered particles, DNA nanotechnology, integrated device development, spatial tissue analysis, and pipelines for high-plex datasets. We employ these tools to study biomolecules in health and disease at multiple scales, including proteins, nucleic acids, extracellular vesicles, cells, and tissues. By tracking disease progression and treatment response, we seek to study the underlying pathologies, and develop better treatment strategies. We work on problems in oncology, autoimmune diseases, infectious diseases, and beyond.

 

Research Keywords

  • Type 1 diabetes genetics, prediction, and prevention
  • Tumor Immunology
  • T-Lymphocytes
  • Spatial tissue profiling
  • Single-cell analysis
  • Point of care tests
  • Nucleic Acid Sequencing
  • Nanotechnology and nanomedicine
  • Microfluidics
  • Lung Cancer
  • Leukemia
  • Immunology
  • Extracellular Vesicles
  • Computational Biology
  • COVID-19
  • Biotechnology

Presentations

  • Biomedical Engineering Seminar Series at UofU "Adventures of probing the immune system through blood". Invited Talk/Keynote, Presented, 12/09/2022.
    https://www.bme.utah.edu/2022/12/05/biomedical-eng...
  • College of Pharmacy Seminar at UofU “Micro-nano technologies for probing the immune system via blood” . Invited Talk/Keynote, Presented, 03/24/2022.
  • PHCEU Seminar at UofU “Micro-nano technologies for probing the immune system via blood”. Invited Talk/Keynote, Presented, 01/10/2022.
  • ECEN681: Bioseminar at Texas A&M “Micro-nano technologies for probing the immune system via blood”. Invited Talk/Keynote, Presented, 11/05/2021.

Research Groups

Languages

  • English, fluent.