Claire Acevedo portrait
  • Adjunct Assistant Professor, Biomedical Engineering
  • Adjunct Assistant Professor, Mechanical Engineering
(801) 581-6623

Publications

  • Heveran CM, Schurman CA, Acevedo C, Livingston EW, Howe D, Schaible EG, Hunt HB, Rauff A, Donnelly E, Carpenter RD, Levi M, Lau AG, Bateman TA, Alliston T, King KB & Ferguson VL (2019). Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice. Bone. Vol. 127, 91-103. Published, 10/2019.
  • Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ & Fields AJ (2018). Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Vol. 33, 1066-1075. Published, 06/2018.
  • Acevedo C, Stadelmann VA, Pioletti DP, Alliston T & Ritchie RO (2018). Fatigue as the missing link between bone fragility and fracture. Nature biomedical engineering. Vol. 2, 62-71. Published, 01/2018.

Research Statement

Our goals are directed toward investigating the mechanisms of deformation, fracture, and the biological responses in biological materials at multiple length-scales (from molecular to macroscales). Our work aims at bridging the gap between mechanics of materials, biology, and experimental high-energy x-ray physics to understand skeletal biology and disease as well as design principles behind biomaterials.

Research Keywords

  • Bone, biomechanics, skeletal tissue, fragility disease, fracture, fatigue, bone quality, synchrotron radiation x-ray, multiscale approach

Presentations

  • Poster presentation: M. Sieverts, C. Yee, M. Nemani, T. Alliston, C. Acevedo, Spatial Control of Perilacunocanalicular Mineral During Lactation, GRC musculoskeletal biology and bioengineering, Andover August 2022. Other, Presented, 08/2022.
  • Dynamic Imaging technique to capture bone damage evolution in bone fragility associated with high collagen glycation, 2021 BONITOS Symposium, Lyon, September 2021 (virtual). Invited Talk/Keynote, Presented, 09/2021.
  • M. Sieverts, Y. Obata, D. Parkinson, H.S. Barnard, D.M. Pelt, C. Acevedo, Understanding Bone’s Fracture Mechanism using Synchrotron Micro-Tomography combined with Deep Learning, 2021 ALS User Meeting, Berkeley, August 2021. Conference Paper, Refereed, Presented, 08/2021.
  • Understanding Bone’s Fracture Mechanism using Synchrotron Micro-Tomography combined with Deep Learning, 2021 ALS User Meeting, Berkeley, August 2021 (virtual). Invited Talk/Keynote, Presented, 08/2021.
  • Tanner Snow, W. Woolley, James Rosenberg, L. Kim, Claire Acevedo, Owen T. Kingstedt, Fracture behavior of collagen-manipulated bovine cortical bone mimicking diabetes skeletal fragility, SEM June 2021. Conference Paper, Refereed, Submitted, 06/2021.
  • M. Sieverts and C. Acevedo, Pushing the limits of Synchrotron Micro-Tomography Understanding Bone’s Fracture Mechanism Using Digital Volume Correlation Enabled by Deep Learning, SBMS Annual Meeting 2021, June 2021. Conference Paper, Refereed, Presented, 06/2021.
  • Yoshihiro Obata, Michael J. Sieverts, Daniël M. Pelt, Claire Acevedo, DIGITAL VOLUME CORRELATION USING DEEP LEARNING-DENOISED SYNCHROTRON MICRO-CT IMAGES TO STUDY BONE MECHANICAL BEHAVIOR, SB3C June 2021. Conference Paper, Refereed, Submitted, 06/2021.
  • Tour de Suisse of Technology: The Fracture and Fatigue of Skeletal Tissues Lab, SBMS Annual Meeting 2021, June 2021 (virtual) - Keynote. Invited Talk/Keynote, Presented, 06/2021.
  • Poster Presentation: William Woolley, James Rosenberg, Tanner Snow, Lily Kim, Owen T. Kingstedt, Claire Acevedo, Low Strain Rate Versus High Strain Rate Biomechanical Behavior of Highly Cross-linked Bones Mimicking Diabetic Bones, ORS meeting, February 2021. Other, Presented, 02/2021.
  • Poster Presentation: M. Sieverts, C. Yee, M. Nemani, T. Alliston, C. Acevedo, Role of MMP13 on Perilacunar Remodeling During Lactation, ASBMR Sept. 2020. Other, Presented, 09/2020.
  • James Rosenberg and Claire Acevedo, Long-term in vivo cyclic loading upregulates the effects of osteoporosis treatment, TMS, February 2020. Conference Paper, Refereed, Accepted, 02/2020.
  • Poster presentation: Vincent A. Stadelmann, James Rosenberg, Ursula Eberli, Stephan Zeiter, Claire Acevedo, C57BL6 mice tibia do not weaken under long-term intense in vivo fatigue loading, ORS meeting, February 2020 . Other, Presented, 02/2020.
  • Poster Presentation: Lily Kim, William Woolley, James Rosenberg, Claire Acevedo, Effects of Increased Non-enzymatic Cross-linking on Mechanical Properties in Bovine Cortical Bone, ORS meeting, February 2020. Other, Presented, 02/2020.
  • James Rosenberg, William Woolley, Tanner Snow, Lily Kim, Mohammed Elamin, Owen T. Kingstedt and Claire Acevedo, Failure mechanisms in ribosylated bones mimicking diabetic bones, ICMOBT, Waikoloa Dec. 2019. Conference Paper, Refereed, Presented, 12/2019.
  • Yoshihiro Obata and Claire Acevedo, Refined methods if image processing for lacunae quantification in diabetic cortical bone, ASME IMECE 2019. Conference Paper, Refereed, Presented, 11/2019.
  • Claire Acevedo, How to use multiscale experimental imaging to understand bone fragility, SB3C, Seven Springs, June 2019. Invited Talk/Keynote, Presented, 06/2019.
  • Claire Acevedo, Investigating bone microstructure using 3D synchrotron radiation Microcomputed tomography, QMSKI International Workshop, Lake Louise (Canada), February 2019. Conference Paper, Refereed, Presented, 02/2019.
  • M. Elamin, T. Snow, J. Rosenberg, C. Acevedo, O.T. Kingstedt, Fracture behavior of bovine cortical embrittled by ribosylation to mimic diabetes skeletal fragility, Society of Experimental Mechanics (SEM) conference. Conference Paper, Refereed, Accepted, 10/2018.
  • Neha S Dole, Cristal S Yee, Claire Acevedo, Courtney M Mazur, Tamara Alliston, TGF beta regulation of perilacunar/canalicular remodeling is sexually dimorphic, ASBMR, Montreal, Sept 2018. Conference Paper, Refereed, Presented, 09/2018.
  • Chelsea M Heveran, Charles Schurman, Claire Acevedo, Eric Schaible, Eric W Livingston, Moshe Levi, Ted Bateman, Tamara Alliston, Karen B King, Virginia L Ferguson, Aging and Chronic Kidney Disease differently diminish bone mechanics from the nano-to whole-bone scales, ASBMR, Montreal, Sept 2018. Conference Paper, Refereed, Presented, 09/2018.
  • Karsyn Bailey, Jonathon Woo, Cristal Yee, Claire Acevedo, Aaron Fields, Jeffrey Lotz, Alexis Dang, Alfred Kuo, Thomas Vail, Tamara Alliston, Defective Perilacunar/Canaticular Remodeling in Subchandral Bone Exacerbates Osteoarthritis, ASBMR, Montreal, Sept. 2018. Conference Paper, Refereed, Presented, 09/2018.
  • Claire Acevedo, New perspectives on bone fragility fracture, AIMM-ASBMR meeting Snowmass, April 2018. Invited Talk/Keynote, Presented, 04/2018.

Research Groups

  • Nikita Rabbitt, Undergraduate Student. 05/2022 - 08/2022.
  • Alexandra Ingram, Undergraduate Student. 05/2022 - 12/2022.
  • Abigail Anderson, Undergraduate Student. 01/2022 - present.
  • Ihsan Elnunu, Graduate Student. Mechanical Engineering. 12/2021 - present. Awards/Scholarships/Stipends: Master student on NIH R21.
  • Qian Wu, Undergraduate Student. 09/2021 - 08/2022.
  • Brooklyn Weight, Undergraduate Student. 06/2021 - present.
  • Emma Lester, Undergraduate Student. 05/2021 - present.
  • Kaitlynn Martin, Undergraduate Student. 05/2021 - present.
  • Yiming Lu, Undergraduate Student. Biomedical Engineering. 01/2021 - present.
  • William Woolley, Graduate Student. Mechanical Engineering. 01/2020 - present.
  • Julia Kamml , Graduate Student. I am co-advisor. 10/2019 - 06/2024.
  • Michael Sieverts, Graduate Student. Mechanical Engineering. 08/2019 - present.
  • Yoshihiro Obata, Graduate Student. Mechanical Engineering. 06/2019 - present.
  • William Woolley, Visiting Student. 03/2019 - 09/2019.
  • Justin J. Schofield, Undergraduate Student. 01/2019 - 05/2019.
  • Lily Mccaslin (Kim), Undergraduate Student. 01/2019 - 12/2020.
  • Julia Dominesey, Undergraduate Student. 06/2018 - 08/2018.