Publications
- Li Q, Ferrare JT, Silver J, Wilson JO & Arteaga-Castaneda L (2023). Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport. Proceedings of the National Academy of Sciences of the United States of America. Vol. 120, e2212507120e2212507120. Published, 01/01/2023.
- Sharma A (2021). Length dependence of the rigidity of microtubules in small networks. Biochemical and biophysical research communications. Vol. 529, 303305303-305. Published, 02/01/2021.
- Doval F & Chiba K (2021). Temperature-dependent activity of kinesins is regulable. Biochemical and biophysical research communications. Vol. 528, 528530528-530. Published, 02/01/2021.
- Sharma A, Preece B, Swann H & Fan X (2021). Structural stability of SARS-CoV-2 virus like particles degrades with temperature. Biochemical and biophysical research communications. Vol. 534, 343346343-346. Published, 01/01/2021.
- Nguyen HC, Talledge N, McCullough J & Sharma A (2020). Membrane constriction and thinning by sequential ESCRT-III polymerization. Nature structural & molecular biology. Vol. 27, 392399392-399. Published, 07/01/2020.
- Tan R, Lam AJ, Tan T & Han J (2019). Microtubules gate tau condensation to spatially regulate microtubule functions. Nature cell biology. Vol. 21, 107810851078-1085. Published, 11/01/2019.
- Osunbayo O, Miles CE & Doval F (2019). Complex nearly immotile behaviour of enzymatically driven cargos. Soft matter. Vol. 15, 184718521847-1852. Published, 03/01/2019.
- Bergman JP, Bovyn MJ, Doval FF & Sharma A (2018). Cargo navigation across 3D microtubule intersections. Proceedings of the National Academy of Sciences of the United States of America. Vol. 115, 537542537-542. Published, 08/01/2018.
- Reddy BJN, Tripathy S, Vershinin M, Tanenbaum ME & Xu J (2018). Heterogeneity in kinesin function. Traffic (Copenhagen, Denmark). Vol. 18, 658671658-671. Published, 06/01/2018.
- Chase K (2017). Enhanced stability of kinesin-1 as a function of temperature. Biochemical and biophysical research communications. Vol. 493, 131813211318-1321. Published, 10/01/2017.
- Gutierrez PA & Ackermann BE (2017). Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. (pp. 122451225512245-12255). Vol. 292. The Journal of biological chemistry. Published, 08/01/2017.
- Hong W & Takshak A (2017). The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors. Biophysical journal. Vol. 111, 128712941287-1294. Published, 07/01/2017.
- Osunbayo O, Butterfield J & Bergman J (2016). Cargo transport at microtubule crossings: evidence for prolonged tug-of-war between kinesin motors. Biophysical journal. Vol. 108, 148014831480-1483. Published, 05/01/2016.
- Smith TE, Hong W, Zachariah MM & Harper MK (2014). Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata. Proceedings of the National Academy of Sciences of the United States of America. Vol. 110, 188801888518880-5. Published, 01/01/2014.
- Yi JY, Ori-McKenney KM & McKenney RJ (2012). High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. The Journal of cell biology. Vol. 195, 193201193-201. Published, 02/01/2012.
- Kunwar A, Tripathy SK, Xu J, Mattson MK & Anand P (2012). Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proceedings of the National Academy of Sciences of the United States of America. Vol. 108, 189601896518960-5. Published, 01/01/2012.
- Kunwar A, Tripathy SK, Xu J, Mattson MK & Anand P (2012). Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proceedings of the National Academy of Sciences of the United States of America. Vol. 108, 189601896518960-5. Published, 01/01/2012.
- McKenney RJ & Vershinin M (2010). LIS1 and NudE induce a persistent dynein force-producing state. Cell. Vol. 141, 304314304-14. Published, 05/01/2010.
- Bremner KH, Scherer J & Yi J (2010). Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell host & microbe. Vol. 6, 523535523-35. Published, 02/01/2010.
- Ziebert F & Vershinin M (2009). Collective alignment of polar filaments by molecular motors. The European physical journal. E, Soft matter. Vol. 28, 401409401-9. Published, 06/01/2009.
- Shubeita GT, Tran SL, Xu J & Vershinin M (2008). Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell. Vol. 135, 109811071098-107. Published, 12/01/2008.
- Kunwar A & Vershinin M (2008). Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport. Current biology : CB. Vol. 18, 117311831173-83. Published, 10/01/2008.
- Vershinin M & Xu J (2008). Tuning microtubule-based transport through filamentous MAPs: the problem of dynein. Traffic (Copenhagen, Denmark). Vol. 9, 882892882-92. Published, 07/01/2008.
- Carter BC (2008). A comparison of step-detection methods: how well can you do?. Biophysical journal. Vol. 94, 306319306-19. Published, 01/01/2008.
- Gross SP (2007). Cargo transport: two motors are sometimes better than one. Current biology : CB. Vol. 17, R478R486R478-86. Published, 09/01/2007.
- Petrov DY, Mallik R & Shubeita GT (2007). Studying molecular motor-based cargo transport: what is real and what is noise?. Biophysical journal. Vol. 92, 295329632953-63. Published, 06/01/2007.
- Martinez JE & Vershinin MD (2007). On the use of in vivo cargo velocity as a biophysical marker. Biochemical and biophysical research communications. Vol. 353, 835840835-40. Published, 03/01/2007.
- Vershinin M & Carter BC (2007). Multiple-motor based transport and its regulation by Tau. Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, 879287-92. Published, 02/01/2007.
- Vershinin M, Misra S & Ono S (2004). Local ordering in the pseudogap state of the high-Tc superconductor Bi2Sr2CaCu2O(8+delta). Science (New York, N.Y.). Vol. 303, 199519981995-8. Published, 04/01/2004.
Research Statement
My work is centered on understanding biological processes across many scales, from atomic and molecular scale up to the scale of living systems. More specifically, I am interested in quantitatively elucidating how molecular processes associated with cytoskeletal proteins give rise to related cellular structure and function. It is now possible to map out the cytoskeleton and associated proteins in a given cell with nanoscale precision via either electron microscopy or super-resolution fluorescence-based studies. However a top-down deconstruction of a cell is insufficient to understand the underlying interactions and overall dynamics. My lab has a vision of surmounting the key hurdle to further progress by experimentally modeling increasing level of complexity from the bottom up without sacrificing experimental control and precision.
Research Keywords
- single molecule assays
- optical trapping
- Viral Studies (Virology)
- Molecular Motors
- Cytoskeleton
Presentations
- Colloquium, National Central University. Invited Talk/Keynote, Presented, 12/2022.
Research Groups
- Katelyn Chase, Undergraduate Student. 06/2017 - 08/2017.
- Abhimanyu Sharma, Graduate Student. 09/2016 - 05/2021.
- Ramona Luna, Undergraduate Student. 06/2016 - 08/2016.
- Florence Doval, Graduate Student. 05/2016 - 05/2020.
- Amihai Meiri , Postdoc. 07/2015 - 11/2015.
- Ryan Weber, Undergraduate Student. 06/2014 - 08/2014.
Research Equipment and Testing Expertise
- Holographic and ordinary optical trapping. Custom setup. Contact: Michael Vershinin , 801-581-5803 , CSC (CCGS office).