Publications

  • Lim T, Kim M & Akbarian A (2022). Conductive Polymer Enabled Biostable Liquid Metal Electrodes for Bioelectronic Applications. Advanced healthcare materials. Vol. 11, e2102382e2102382. Published, 06/01/2022.
  • Oakes, RS & Polei, MD, Skousen JL, Christensen MB, Tresco PA, (2019). An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex. Elsevier. Vol. 154, 154:1-11. Published, 11/12/2019.
  • 93. Christensen, M.B., Tresco, P.A. (2018). The foreign body response and morphometric changes associated with mesh-style peripheral nerve cuffs to peripheral nerve cuffs made of synthetic biomaterials. Elsevier. Vol. 17, 30756-0. Published, 12/2018.
  • Christensen MB & Tresco PA (2018). The foreign body response and morphometric changes associated with mesh-style peripheral nerve cuffs. Acta biomaterialia. Vol. 67, 79-86. Published, 08/01/2018.
  • Oakes RS, Polei MD, Skousen JL & Tresco PA (2018). An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex. Biomaterials. Vol. 154, 1-11. Published, 07/01/2018.
  • Christensen MB & Tresco PA (2018). The foreign body response and morphometric changes associated with mesh-style peripheral nerve cuffs. Acta biomaterialia. Vol. 67, 79-86. Published, 02/01/2018.
  • 94. Oakes, RS, & Polei, MD, Skousen JL, Christensen MB, Tresco PA (2018). An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex,. Elsevier. Vol. 154, 2-11. Published, 02/2018.
  • Oakes RS, Polei MD, Skousen JL & Tresco PA (2017). An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex. Biomaterials. Vol. 154, 1-11. Published, 12/01/2017.
  • Meng, FW, Hlady, V and PA Tresco, Inducing alignment in astrocyte tissue constructs by surface ligands patterned on biomaterials, Biomaterials. 2012 Feb;33(5):1323-35. Published, 02/2012.
  • Meng, FW, Hlady, V and PA Tresco, Inducing alignment in astrocyte tissue constructs by surface ligands patterned on biomaterials, Biomaterials. 2012 Feb;33(5):1323-35. Published, 02/2012.
  • Hodgkinson , GN, Tresco, PA and V Hlady, The role of well-patterned substrata on the regeneration of DRG neuron pathfinding and integrin expression dynamics using chonrdroitin sulfate proteoglycans, Biomaterials 2012. Published, 02/2012.
  • Williams, RR, Pearse, DD Tresco PA, and MB Bunge, The use of an adeno-associated viral vector to assess the regeneration of brainstem axons into a Schwann cell bridge, J Gene Med. 2012 Jan;14(1):20-34. Published, 01/2012.
  • Skousen, JL, Bridge, MJ, Merriam, Sr. ME, Srivannavit, O, Perlin, G Wise, K and Tresco, PA, Reducing surface area while maintaining implant penetrating profile lowers the foreign body response to chronically implanted planar silicon microelectrode arrays, Prog Brain Res. 2011;194:167-80. Published, 10/2011.
  • Meng, FW, Hlady, V and PA Tresco, Inducing alignment in astrocyte tissue constructs by surface ligands patterned on biomaterials, Biomaterials. 2012 Feb;33(5):1323-35. Published, 05/2011.
  • Bridge, J and Tresco, P.A. In Vivo solute diffusivity in brain tissue surrounding indwelling neural Implants, In, Indwelling Neural Implants:Strategies for Contending with the In Vivo Environment, edited WM Reichert, CRC Press ISBN978-0-8493-9362. Published, 2009.
  • Brain-Computer Interfaces, An International Assessment of Research and Development Trends (2008) Berger, TW, Chapin JK, Gerhardt, GA, Mcfarland, DJ, Principe, JC, Soussou, WV, Taylor, DM and PA Tresco, Springer Science and Business Media, ISBN: 978-1-4020-8704-2. Published, 10/01/2008.
  • 69. Smeal, R and PA Tresco, The Influence of Substrate Curvature on Neurite Outgrowth is Cell Type Dependent, Exp Neurol. 2008 Oct;213(2):281-92. Published, 2008.
  • 70. Hodgkinson, G. Tresco, PA , and Hlady, V. The influence of sub-micron inhibitory cluster on growth cone substratum attachments and CD44 expression, Biomaterials Biomaterials. 2008 Nov;29(31):4227-35. Published, 2008.
  • 67. Gupta, KM, Pearce, SM, Aliyar, HA, Tresco, PA, Mitchnik, and PF Kiser. Polyurethane intravaginal ring for controlled delivery of dapivirine, a non-nucleoside reverese transcriptase inhibitor of HIV-1, Journal of Pharmaceutical Sciences, J Pharm Sci. 2008 Oct;97(10):4228-39. Published, 2008.
  • 68. Leung, B. Biran, R, Underwood, CJ, and PA. Tresco, Characterization of microglial attachment and cytokine release on biomaterials of differing surface chemistry, Biomaterials, Biomaterials. 2008 Aug;29(23):3289-97. Published, 2008.
  • 71. Wolchok, JC,Brokopp, C, Underwood CJ and PA Tresco, The effect of bioreactor induced vibrational stimulation on extracellular matrix production form human derived fibroblasts, Biomaterials. 2008 Jan;30(3):327-35. Published, 2008.

Research Statement

Our group is developing several biomaterial technologies for the reconstruction, replacement, and repair of damaged CNS tissues, including specialized devices for cell transplantation and biomaterials for targeting nerve outgrowth. A central theme in our work involves understanding how nervous tissue responds to implants that vary in their physical and chemical properties. In addition, we recently began developing biomaterials and force generating bioreactors capable of simulating the microenvironment of the vocal fold tissue.

Presentations

  • 242. Ahmed, B, Boroomand, S, Strathman, HJ, Hantak, M, Sheperd, T, Koch, A, Binder, S Ehrenhofer, A, Shepherd, J, Solzbacher, F, Reiche, CF, Tresco, PA, Blair, S, Fan,Y, Establishing a biotic connection to the brain: An innovative transition micro-electrode array technology for neural recording and stimulation. 11th International IEEE EMBS Conference on Neural Engineering, Baltimore, MD, 2023. Conference Paper, Refereed, Presented, 10/2023.
  • 241. Nelson, M. PA Tresco and B Gale. A 3-D printed breathing lung-on-a-chip with an integrated extracellular matrix membrane, UBEC, SLC, UT, 2023. Conference Paper, Refereed, Presented, 09/2023.
  • 238. Velagapudi, Bharath, Polei, MD, Tresco, PA. Reducing microelectrode shaft size and including a soft permeable base coating improves UEA biocompatibility, Society for Biomaterials, Atlanta, GA 2019. (best poster award). Other, Presented, 11/12/2019.
  • 61. The Challenge of Integrating High Density Recording Arrays into the Cortex”, (2018) Department of Biomedical Engineering, University of Miami, Miami, Fl. Invited Talk/Keynote, Presented, 10/2018.
  • 237. Polei, MD, Velagapudi, B and Tresco, PA. A comparision of the FBR to Tethered and Untethered UEAs in rat cortex, Society for Biomaterials, Atlanta, GA 2018. Conference Paper, Refereed, Accepted, 04/2018.
  • 238. Velagapudi, Bharath, Polei, MD, Tresco, PA. Reducing microelectrode shaft size and including a soft permeable base coating improves UEA biocompatibility, Society for Biomaterials, Atlanta, GA 2018. (best poster award). Conference Paper, Refereed, Presented, 04/2018.
  • 237. Polei, MD, Velagapudi, B and Tresco, PA. A comparison of the FBR to Tethered and Untethered UEAs in rat cortex, Society for Biomaterials, Atlanta, GA 2018. Conference Paper, Refereed, Presented, 04/2018.
  • 238. Velagapudi, Bharath, Polei, MD, Tresco, PA. Reducing microelectrode shaft size and including a soft permeable base coating improves UEA biocompatibility, Society for Biomaterials, Atlanta, GA 2018. Conference Paper, Refereed, Accepted, 04/2018.
  • 235. Velagapudi, B, Polei, MD, Tresco, PA. Increasing Base Permeability of the Utah Electrode Array Improves Integration in Cortical Tissue, 47th Annual Meeting Society for Neuroscience, Washington, DC November, 2017. Conference Paper, Refereed, Presented, 11/2017.
  • 236. Polei, MD, Velagapudi, B, Tresco, PA. The Effect of Headstage Tethering on the Orientation of High Density Electrode Arrays Implanted in Rat Cortex, 47th Annual Meeting Society for Neuroscience Washington, DC November, 2017. Conference Paper, Refereed, Accepted, 11/2017.
  • 60. The Challenge of Integrating High Density Recording Arrays into the Cortex”, (2017) International Conference of Brain links and Brain tools, University of Freiburg, Germany. Invited Talk/Keynote, Presented, 07/2017.
  • 14. Panel on the Future of Cortically Controlled Neuroprosthetics, International Conference of Brain links and Brain tools (2017) University of Freiburg, Germany. Other, Presented, 07/2017.
  • 232. Velagapudi, B., Christensen MB, Tresco, PA. “Elucidating the Role of Macrophage Lineage in the FBR to Chronically Implanted Microelectrode Arrays” Annual Meeting Society for Neuroscience San Diego, CA November, 2016. 233. Polei, MD, Velagapudi, B, Tresco, PA. “ECM Coatings Minimize FBR to Chronically Implanted CNS High Density Recording Arrays” Annual Society for Neuroscience Conference, San Diegio, November, 2016. 234. Polei, MD, Velagapudi, B, Tresco, PA. “ECM Coatings Minimize FBR to Chronically Implanted CNS High Density Recording Arrays” Biomedical Engineering Society Annual Meeting, October, 2016. Conference Paper, Refereed, Presented, 10/2016.
  • The effect of aging on neural recording performance in chronic applications”, (2014) DARPA RE-NET Program Review, Feb 12-13, Scottsdale, AZ. Invited Talk/Keynote, Presented, 02/2014.
  • 212. Christensen, MB, Nolta, NF and Tresco, PA, BBB leakiness is associated with recording changes in chronically implanted UEAs, Annual meeting of the Society for Biomaterials, April, 16-19, Denver, CO, 2014. Conference Paper, Refereed, Accepted, 01/2014.
  • 214. Polei, MD, Oakes, RS, Skousen, JL and Tresco, PA, the use of extracellular matrix coatings to immunomudulate the FBR to microelectrode arrays implanted in rat cortex, Annual meeting of the Society for Biomaterials, April, 16-19, Denver, CO, 2014. Conference Paper, Refereed, Accepted, 01/2014.
  • 213. Oakes, RS, Christensen, MB and Tresco, PA, the foreign body response to headstage components adds to the neuroinflammatory burden of indwelling microelectrode arrays, Annual meeting of the Society for Biomaterials, April, 16-19, Denver, CO, 2014. Conference Paper, Refereed, Accepted, 01/2014.
  • 208. Christensen, MB, Skousen, JL, Khan, N, Tresco, PA, Cell-specific ecm down-regulates inflammatory response to nervous system implants, Annual meeting of the Society for Biomaterials, April, 10-13, Boston MA, 2013. Conference Paper, Refereed, Accepted, 01/2014.
  • 216. Velagapudi, B, Crane, P, Nolta, NF and Christensen, MB and Tresco, PA, Forensic analysis if retrieved utah electrode arrays following implantation into rat cortex, Annual meeting of the Society for Biomaterials, April, 16-19, Denver, CO, 2014. Conference Paper, Refereed, Accepted, 01/2014.
  • 215. Nolta, NF, Christensen, MB and Tresco, PA, Studies of the foreign body response to chronically implanted Utah electrode arrays in rat cortex, Annual meeting of the Society for Biomaterials, April, 16-19, Denver, CO, 2014. Conference Paper, Refereed, Accepted, 01/2014.
  • 58. “Problems at the Neural Interface-Longevity” (2013) Symposium on Problems at the Neural Interface, 6th International IEEE Neural Engineering Conference, San Diego, California. Invited Talk/Keynote, Presented, 12/2013.
  • 205. Oakes, RS, Christensen, MB, and Tresco, PA, The foreign body response to headstage fixation screws alters the cytoarchitecture of the underlying cortical tissue, 43rd Annual Meeting, Society for Neuroscience, San Diego, CA., November 9-13th, 2013. Conference Paper, Refereed, Presented, 11/2013.
  • 204. Velagapudi, B, Crane, P Nolta, N, Christensen, MB< and Tresco, PA, Forensic analysis of retrieved Utah electrode arrays following implantation into rat cortex, 43rd Annual Meeting, Society for Neuroscience, San Diego, CA., November 9-13th, 2013. Conference Paper, Refereed, Presented, 11/2013.
  • 207. Christensen, MB, Nolta, and Tresco PA, Quantitative correlation of electrode functionality to end-point histology, 43rd Annual Meeting, Society for Neuroscience, San Diego, CA., November 9-13th, 2013. Conference Paper, Refereed, Presented, 11/2013.
  • 206. Nolta, N, Christensen, MB, Crane, P, Tresco, PA, A CAD modeling approach that predicts the foreign body response to chronically implanted electrode arrays, 43rd Annual Meeting, Society for Neuroscience, San Diego, CA., November 9-13th, 2013. Conference Paper, Refereed, Presented, 11/2013.
  • 201. Farhang, N. Polei, M. Christensen, MB, Tresco, PA, A mesenchymal stem cell derived extracellular matrix approach for cartilage repair, BMES Annual Meeting, Seattle WA, 2013. Conference Paper, Refereed, Presented, 09/2013.
  • 203. Christensen, MB, Nolta, N Skousen, S, and Tresco PA, Histological correlates to functionality in 4 X 4 Utah electrode arrays in rat cortex, BMES Annual Meeting, Seattle WA, 2013. Conference Paper, Refereed, Presented, 09/2013.
  • 202. Nolta, N, Christensen, MB, Crane, P, Tresco, PA, A CAD modeling approach that predicts the foreign body response to chronic implants, BMES Annual Meeting, Seattle WA, 2013. Conference Paper, Refereed, Presented, 09/2013.
  • 211. Christensen, MB, Nolta, NF, Skousen, JL and Tresco, PA, Evaluation of failure mechanism of Utah electrode arrays in rat cortex, Annual meeting of the Society for Biomaterials, April, 10-13, Boston MA, 2013. Conference Paper, Refereed, Presented, 04/2013.
  • 210. Nolta, N, Skousen, JL, Christensen MB, Tresco, PA, Finite element modeling of strategies to reduce the foreign body response to neural electrodes chronically implanted in brain tissue, Annual meeting of the Society for Biomaterials, April, 10-13, Boston MA, 2013. Conference Paper, Refereed, Presented, 04/2013.
  • 209. Christensen, MB, Winslow, BD, Higgins AE, and Tresco, PA, Hippocampal neurogenesis is down-regulated in animals with small scale nervous system implants, Annual meeting of the Society for Biomaterials, April, 10-13, Boston MA, 2013. Conference Paper, Refereed, Presented, 04/2013.
  • 192. Oakes R, Skousen JL, Meng FWand Tresco PA (2012) Cell-Derived Coatings to Decrease the Inflammatory Response around Neural Implants; Society for Neuroscience, New Orleans, LA. Conference Paper, Refereed, Presented, 11/15/2012.
  • A Predictive Model of the Foreign Body Response to Devices Implanted Chronically in the Central Nervous System” (2012) Annual conference of the International Functional Electrical Stimulation Society (Smart Machines-Neural Evolution), Banff, Alberta, Canada. Invited Talk/Keynote, Presented, 10/2012.
  • Modeling the Brain Tissue Response to Neural Interfaces: Towards Informed Designs“ (2012) McGowan Institute Scientific Retreat, University of Pittsburgh, Pittsburgh, PA. Invited Talk/Keynote, Presented, 10/2012.
  • Manipulating the Foreign Body Response to Neural Recording Devices Implanted Chronically in Brain Tissue”. (2012) 14th International Meeting on Monitoring Molecules in Neuroscience, London, England. Invited Talk/Keynote, Presented, 10/2012.
  • 189. Oakes R, Skousen JL, Meng FW and Tresco PA (2012) Cell-Derived Coatings to Decrease the Inflammatory Response around Neural Implants; Biomedical Engineering Society, Atlanta, GA. Conference Paper, Refereed, Presented, 09/2012.
  • A New Approach to Passively Reduce Inflammation Surrounding Microelectrode Arrays Implanted Chronically In Brain Tissue” (2012) 34th Annual International Conference of the IEEE, San Diego, CA. Invited Talk/Keynote, Presented, 06/2012.
  • 171. Meng, FW, Hlady, V, and PA Tresco. (2010) A 3D scaffold-free aligned astrocytes construct for therapeutic applications, 40th Annual Society for Neuroscience, San Diego CA. Conference Paper, Refereed, Presented, 11/07/2010.
  • 174. Skousen, JL, Winslow, BD, Merriam, ME Srivannavit, O, Perliin, G, Wise, KD and PA Tresco. (2010)electrode constitutive properties modulate the brain tissue foreign body response, 40th Annual Society for Neuroscience, San Diego, CA. Conference Paper, Refereed, Presented, 11/07/2010.
  • 173. Wolchok, JC, and PA Tresco. (2010) Astrocyte and glial restricted precursor-derived biomaterials, 40th Annual Society for Neuroscience, San Diego, CA. Conference Paper, Refereed, Presented, 11/07/2010.
  • 172. Winslow, BD, Hinckley, P, Skousen, JL, Merriamise , KD and PA Tresco. (2010)Reducing the inflammatory footprint of a chronically implanted microelectrode arrayt reduces it impact on hippocampal neurogenesis, 40th Annual Society for Neuroscience, San Diego, CA. Conference Paper, Refereed, Other, 11/07/2010.
  • 175. Christensen, MB Wolchok, JC, and PA Tresco. (2010) A natural, allogeneic, extracellular matrix derived peripheral nerve cuff, 40th Annual Society for Neuroscience, San Diego, CA. Conference Paper, Refereed, Presented, 11/07/2010.
  • 177. Christensen, M and PA Tresco, (2010) Fibroblast-derived, ECM-enriched biomaterials for use in nerve repair, Society for Biomaterial Annual Meeting, Orlando, Fl, April. Conference Paper, Refereed, Submitted, 10/08/2010.
  • 176. Meng, FW, Hlady, V and PA Tresco, (2010) 3D, scaffold free astrocyte/tissue construct for spinal cord injury therapeutic application, Society for Biomaterial Annual Meeting, Orlando, Fl, April. Conference Paper, Refereed, Submitted, 10/08/2010.
  • 178. Skousen, JL and PA Tresco (2010) Astrocyte and Glial Restricted Precursor Derived Biomaterials as Coatings for Chronically Implanted CNS Devices, Society for Biomaterial Annual Meeting, Orlando, Fl, April. Conference Paper, Refereed, Submitted, 10/08/2010.
  • Lessons learned from chronic histological studies of recording electrodes”, (2010) Building Better Brains: Neural prosthetics and beyond, New York Academies of Sciences, Aspen, CO. Invited Talk/Keynote, Presented, 09/21/2010.
  • A Biologically-based Design Strategy for Reducing the Foreign Body Response to Chronically Implanted Neural Interfaces”, (2010) Brain Machine Interfaces: Implications for science, clinical practice, and society, Ystadsaltsjobad, Sweden. Invited Talk/Keynote, Presented, 09/12/2010.
  • 170. Tresco, PA. (2010) A Biologically-based Design Strategy for Reducing the Foreign Body Response to Chronically Implanted Neural Interfaces. 2nd International Conference on Neuroprosthetic Devices. Beijing,China. Conference Paper, Refereed, Presented, 01/30/2010.
  • Meng, FW, Skousen, JL, Hlady, V, and PA Tresco. (2009) Nanochemically aligned astrocytes transmit guidance cues to overlying neurites through discrete arrays of apical surface membrane bound ligands, 39th Annual Society for Neuroscience, Chicago, Ill. Conference Paper, Refereed, Presented, 2009.
  • Tresco, PA. A Biologically-based Design Strategy for Reducing the Foreign Body Response to Chronically Implanted Neural Interfaces. 2nd International Conference on Neuroprosthetic Devices. Beijing,China. Invited Talk/Keynote, Submitted, 2009.
  • Winslow, B, Christensen, B and PA Tresco. The influence of device geometry on the foreign body response to implanted microelectrode arrays and array assemblies. 38th Annual Meeting Society for Neuroscience. Conference Paper, Presented, 2008.
  • Chen, X K and PA Tresco. Inflammation associated secondary cell loss near cortical microelectrode arrays is a part of the early phase of the foreign body response. 38th Annual Meeting Society for Neuroscience. Conference Paper, Presented, 2008.
  • Christensen, MB Pearce, SM and PA Tresco. Characterization of the foreign body response to penetrating microelectrode arrays in cat sciatic nerves. Submitted to 38th Annual Meeting Society for Neuroscience. Conference Paper, Presented, 2008.
  • Skousen, JL Meng, FW Hlady, V. and PA Tresco. A biomimetic, nanochemical strategy for reducing device-associated inflammation in the central nervous system. 38th Annual Meeting Society for Neuroscience. Conference Paper, Presented, 2008.
  • Wolchok, J., and Tresco, P.A., (2008) A novel method to grow and extract a cell derived ECM from an open celled polymer foam,” BMES Annual Fall Meeting, Saint Louis, MO. Conference Paper, Presented, 2008.
  • The Challenge of Integrating Materials into the Nervous System for Long-term Applications”, (2008) NanoNeuro Research Center, Lund University, Lund, Sweden. Invited Talk/Keynote, Presented, 2008.
  • The influence of device geometry on the foreign body response to microelectrode arrays and array assemblies implanted in brain tissue” (2008) NSF/IMEC Workshop on "Micro/Nanoelectronics: Devices and Technologies for Biomedical Applications," Interuniversity Microelectronics Centre (IMEC) Leuven, Belgium. Invited Talk/Keynote, Presented, 2008.
  • Nanotechnology and Neural Engineering: Implications for Neural regeneration and improvements in Biocompatibility, (2008), Department of Cell and Organism Biology, Lund University, Lund, Sweden. Invited Talk/Keynote, Presented, 2008.
  • Neural Implant Design Rationalized on the Basis of the Foreign Body Response, (2008) Department of Bioengineering, University of Florida, Gainesville. Invited Talk/Keynote, Presented, 2008.